The interplay between cell signalling and the mevalonate pathway in cancer

Nature Reviews Cancer 16, 718 (2016). doi:10.1038/nrc.2016.76 Authors: Peter J. Mullen, Rosemary Yu, Joseph Longo, Michael C. Archer & Linda Z. Penn The mevalonate (MVA) pathway is an essential metabolic pathway that uses acetyl-CoA to produce sterols and isoprenoids that are integral to tumour growth and progression. In recent years, many oncogenic signalling pathways have been shown to increase the activity and/or the expression of MVA pathway
Source: Nature Reviews Cancer - Category: Cancer & Oncology Authors: Tags: Review Source Type: research