Usual interstitial pneumonia end-stage features from explants with radiologic and pathological correlations
Idiopathic pulmonary fibrosis (IPF) is the most frequent and severe idiopathic interstitial pneumonia, with typical high-resolution computed tomography (HRCT) features and histologic pattern of usual interstitial pneumonia (UIP); its main differential diagnosis is fibrotic nonspecific interstitial pneumonia (F-NSIP). Usual interstitial pneumonia was mainly described from lung biopsies, and little is known on explants. Twenty-two UIP/IPF explants were analyzed histologically and compared with previous open lung biopsies (OLBs; n = 11) and HRCT (n = 19), when available. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - May 13, 2015 Category: Pathology Authors: Maud Rabeyrin, Françoise Thivolet, Gilbert R. Ferretti, Lara Chalabreysse, Adrien Jankowski, Vincent Cottin, Christophe Pison, Jean-François Cordier, Sylvie Lantuejoul Tags: Radiologic-Pathologic Correlation Source Type: research
Usual interstitial pneumonia end-stage features from explants with radiological and pathological correlations
Idiopathic pulmonary fibrosis (IPF) is the most frequent and severe idiopathic interstitial pneumonia, with typical high-resolution computed tomography (HRCT) features and histological pattern of usual interstitial pneumonia (UIP); its main differential diagnosis is fibrotic non-specific interstitial pneumonia (F-NSIP). UIP was mainly described from lung biopsies and little is known on explants. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - May 13, 2015 Category: Pathology Authors: Maud Rabeyrin, Françoise Thivolet, Gilbert R. Ferretti, Lara Chalabreysse, Adrien Jankowski, Vincent Cottin, Christophe Pison, Jean-François Cordier, Sylvie Lantuejoul Source Type: research
Toll-like receptor 4–induced inflammatory responses contribute to the tumor-associated macrophages formation and infiltration in patients with diffuse large B-cell lymphoma
To evaluate the expression of tumor-associated macrophages (TAMs) and Toll-like receptor 4 (TLR4) in diffuse large B-cell lymphoma (DLBCL) and their correlation with patient clinical characteristics, we detected using immunohistochemistry in 81 specimens of patients with DLBCL. The correlation between protein expression levels and clinical parameters, as well as the association between CD68 and TLR4 were analyzed. The number of CD68 TAMs was closely related to β2-microglobulin (P = .028 and P < .05), whereas there was no significant correlation between the number of CD68 TAMs and other clinical factors. (Source: Annals of...
Source: Annals of Diagnostic Pathology - May 12, 2015 Category: Pathology Authors: Xiaofang Wang, Xiangli Li, Xiaoying Zhang, Li Zang, Hongliang Yang, Weipeng Zhao, Haifeng Zhao, Qian Li, Bing Xia, Yong Yu, Yafei Wang, Zhigang Zhao, Yizhuo Zhang Tags: Original Contributions Source Type: research
Anaplastic lymphoma kinase gene expression in small round cell tumors of childhood—a comparative ımmunohistochemical study
The focus of this study was to investigate anaplastic lymphoma kinase (ALK) expression by immunohistochemistry using a highly specific antibody. Distribution and frequency of ALK expression may provide a clue for ALK inhibitor use in small round cell tumors of childhood. The study group involved 76 small round cell tumors of childhood, which composed of 11 rhabdomyosarcomas, 13 Wilms tumors, 7 Ewing sarcoma/primitive neuroectodermal tumors, 34 peripheral neuroblastic tumors, and 11 acute lymphoblastic lymphoma. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - May 12, 2015 Category: Pathology Authors: Esra Karakuş, Suna Emir, Ayper Kaçar, Resul Karakuş, Hacı Ahmet Demir, Derya Özyörük Tags: Original Contribution Source Type: research
Chromophobe renal cell carcinoma with neuroendocrine and neuroendocrine-like features. Morphologic, immunohistochemical, ultrastructural, arrayCGH analysis of 18 cases and review of the literature
Chromophobe renal cell carcinoma (CRCC) with neuroendocrine differentiation (CRCCND) has only recently been described. 18 cases of CRCC with morphologic features suggestive of neuroendocrine differentiation were selected from among 624 CRCC in our registry. The tissues were fixed in neutral formalin, embedded in paraffin, cut into 4 -5 μm thin sections and stained with Hematoxylin and Eosin (H&E). As CRCC with neuroendocrine features were suggested tumors with following morphology: 1, trabecular/palisading/ribbon-like, gyriform, insular, glandular and solid pattern. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - May 12, 2015 Category: Pathology Authors: Kvetoslava Peckova, Petr Martinek, Chisato Ohe, Naoto Kuroda, Stela Bulimbasic, Enric Condom Mundo, Delia Perez Montiel, Jose I. Lopez, Ondrej Daum, Pavla Rotterova, Bohuslava Kokoskova, Magdalena Dubova, Kristyna Pivovarcikova, Kevin Bauleth, Petr Grossm Tags: Original Contributions Source Type: research
A standardized method for quantifying proliferation by Ki-67 and cyclin A immunohistochemistry in breast cancer
This study was performed to compare the Ki-67 and cyclin A expression counted in hot spot versus average counting based on 5-14 random tumor areas in 613 breast carcinomas. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - May 12, 2015 Category: Pathology Authors: Kun Mu, Li Li, Qingrui Yang, Haiqin Yun, Pedram Kharaziha, Ding-wei Yed, Gert Auer, Svetlana Bajalica Lagercrantz, Anders Zetterberg Tags: Original Contributions Source Type: research
Anaplastic Lymphoma Kinase (ALK) Gene Expression in Small Round Cell Tumors of Childhood - A Comparative Immunohistochemical Study
The focus of this study was to investigate ALK expression by immunohistochemistry using a highly specific antibody. Distribution and freqency of ALK expression may provide a clue for ALK inhibitor use in small round cell tumors of childhood. The study group involved 76 small round cell tumors of childhood, which composed of 11 rhabdomyosarcomas, 13 Wilms’ tumors, 7 Ewing sarcoma/primitive neuroectodermal tumors, 34 peripheral neuroblastic tumors, and 11 acute lymphoblastic lymphoma. ALK protein expression in small round cell tumors of childhood are poorly described in the literature. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - May 12, 2015 Category: Pathology Authors: Esra Karakuş, Suna Emir, Ayper Kaçar, Resul Karakuş, Hacı Ahmet Demir, Derya Özyörük Tags: Original Contribution Source Type: research
TLR4-induced inflammatory responses contribute to the tumor-associated macrophages formation and infiltration in patients with diffuse large-B cell lymphoma
To evaluate the expression of tumor-associated macrophages (TAMs) and Toll-like receptor 4 (TLR4) in diffuse large-B cell lymphoma (DLBCL) and their correlation with patient clinical characteristics, we detected using immunohistochemistry in 81 specimens of DLBCL patients. The correlation between protein expression levels and clinical parameters, as well as the association between CD68 and TLR4 were analyzed. The number of CD68 TAMs was closely related with β2-Microglobulin (P=0.028, (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - May 12, 2015 Category: Pathology Authors: Xiaofang Wang, Xiangli Li, Xiaoying Zhang, Li Zang, Hongliang Yang, Weipeng Zhao, Haifeng Zhao, Qian Li, Bing Xia, Yong Yu, Yafei Wang, Zhigang Zhao, Yizhuo Zhang Tags: Original Contributions Source Type: research
Editorial Board
(Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - May 10, 2015 Category: Pathology Source Type: research
Masthead
(Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - May 10, 2015 Category: Pathology Source Type: research
Table of Contents
(Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - May 10, 2015 Category: Pathology Source Type: research
Desmoglein 3 and p40 immunoreactivity in neoplastic and nonneoplastic thymus: a potential adjunct to help resolve selected diagnostic and staging problems
The potential usefulness of the squamous markers p40 and desmoglein 3 (DSG-3) for the diagnosis and staging of selected thymic lesions is uncertain. We investigated their expression and distribution pattern in 66 thymomas, 12 thymic squamous carcinomas, 6 undifferentiated thymic carcinomas, 5 hyperplastic thymi, and 5 normal thymi. p40 nuclear and DSG-3 cytoplasmic/membranous immunoreactivity in greater than or equal to 10% of thymic epithelial cells was interpreted as positive, and DSG-3 distribution pattern was classified as organotypic and nonorganotypic. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - May 6, 2015 Category: Pathology Authors: Ann E. Walts, Kenzo Hiroshima, Alberto M. Marchevsky Tags: Original Contribution Source Type: research
Mucinous Spindle and Tubular Renal Cell Carcinoma: Analysis of Chromosomal Aberration Pattern of Low-grade, High-grade and Overlapping Morphologic Variant with Papillary Renal Cell Carcinoma
The objective of this study is to map the spectrum of chromosomal aberrations (extent and location) in a large cohort of the cases and relate these findings to the morphologic variants of MTSRCC. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - May 6, 2015 Category: Pathology Authors: Kvetoslava Peckova, Petr Martinek, Maris Sperga, Delia Perez Montiel, Ondrej Daum, Pavla Rotterova, Kristýna Kalusová, Milan Hora, Kristýna Pivovarcikova, Boris Rychly, Semir Vranic, Whitney Davidson, Josef Vodicka, Magdaléna Dubová, Michal Michal, O Tags: Original Contribution Source Type: research
Sclerosing Epithelioid Fibrosarcoma of the Kidney: Clinicopathologic and Molecular Study of a Rare Neoplasm at a Novel Location
Sclerosing epithelioid fibrosarcoma (SEF) is a rare fibrosarcoma variant with specific histomorphology and consistent translocation (EWSR1-CREB3L1/2). To date, ̴ 110 cases have been reported; only 15 originated within the abdomen. With only 3 cases reported parallel to our study, primary renal SEF are exceptionally rare but might be under-recognized. We herein describe two cases affecting a 23–year-old female and a 43-year-old male. Tumor size was 22 cm and 4.2 cm, respectively. Patient 1 developed skeletal and multiple pulmonary metastases. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - May 6, 2015 Category: Pathology Authors: Carsten-Henning Ohlmann, Ines B. Brecht, Kerstin Junker, Jill A. van der Zee, Adriana Nistor, Rainer M. Bohle, Michael Stöckle, Markus Metzler, Arndt Hartmann, Abbas Agaimy Tags: Original Contribution Source Type: research
Desmoglein-3 and P40 Immunoreactivity in Neoplastic and Non-neoplastic Thymus: A potential adjunct to help resolve selected diagnostic and staging problems
The potential usefulness of the squamous markers p40 and desmoglein-3 (DSG-3) for the diagnosis and staging of selected thymic lesions is uncertain. We investigated their expression and distribution pattern in 66 thymomas, 12 thymic squamous carcinomas, 6 undifferentiated thymic carcinomas, 5 hyperplastic thymi, and 5 normal thymi. P40 nuclear and DSG-3 cytoplasmic/membranous immunoreactivity in ≥ 10% of thymic epithelial cells were interpreted as positive and DSG-3 distribution pattern was classified as organotypic and non-organotypic. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - May 6, 2015 Category: Pathology Authors: Ann E. Walts, Kenzo Hiroshima, Alberto M. Marchevsky Tags: Original Contributions Source Type: research
