Chromophobe renal cell carcinoma with neuroendocrine and neuroendocrine-like features. Morphologic, immunohistochemical, ultrastructural, arrayCGH analysis of 18 cases and review of the literature

Chromophobe renal cell carcinoma (CRCC) with neuroendocrine differentiation (CRCCND) has only recently been described. 18 cases of CRCC with morphologic features suggestive of neuroendocrine differentiation were selected from among 624 CRCC in our registry. The tissues were fixed in neutral formalin, embedded in paraffin, cut into 4 -5 μm thin sections and stained with Hematoxylin and Eosin (H&E). As CRCC with neuroendocrine features were suggested tumors with following morphology: 1, trabecular/palisading/ribbon-like, gyriform, insular, glandular and solid pattern.

Source: Annals of Diagnostic Pathology - May 12, 2015 Category: Pathology Authors: Kvetoslava Peckova, Petr Martinek, Chisato Ohe, Naoto Kuroda, Stela Bulimbasic, Enric Condom Mundo, Delia Perez Montiel, Jose I. Lopez, Ondrej Daum, Pavla Rotterova, Bohuslava Kokoskova, Magdalena Dubova, Kristyna Pivovarcikova, Kevin Bauleth, Petr Grossm Tags: Original Contributions Source Type: research