Myoepithelioma of Soft Tissue: A Cytological-Pathological Correlation with Literature Review
We report a case in a 60-year-old male with a painless slowly growing 3cm mass on left medial forefoot. Core biopsy of the mass showed a neoplastic proliferation of plasmacytoid tumor cells, consistent with myoepithelioma of soft tissue. Immunohistochemical stains demonstrated positivity of the tumor cells for cytokeratin AE1/AE3, CK18, S-100 protein and myosin heavy chain (SMMS-1), supporting the diagnosis. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - January 5, 2017 Category: Pathology Authors: Oleksandr Kravtsov, Jason Chang, Donald Hackbarth, Tamara Giorgadze Source Type: research
Macrocystic ductal adenocarcinoma of prostate: A rare gross appearance of prostate cancer
Macroscopic cyst-formation by prostatic adenocarcinoma, herein referred to as macrocystic prostatic adenocarcinoma (MPA), is extremely rare. To date, no studies of prostate cancer performed based on gross cystic appearance have been reported. MPA can include various diseases, one of which is cystadenocarcinoma. Several cases of ductal adenocarcinoma exhibiting a macrocystic appearance have recently been reported; however, the histological and clinicopathological characteristics of MPAs have yet to be characterized and established. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - December 27, 2016 Category: Pathology Authors: Fumiyoshi Kojima, Hiroyuki Koike, Ibu Matsuzaki, Yoshifumi Iwahashi, Kenji Warigaya, Masakazu Fujimoto, Kazuo Ono, Youji Urata, Yasuo Kohjimoto, Isao Hara, Shin-ichi Murata Source Type: research
Chronic myeloid leukemia with a rare fusion transcript, e19a2 BCR –ABL1: A report of three cases from India
The μ-bcr breakpoint connects exon 19 of BCR with ABL giving rise to the e19a2 transcript corresponding to the p230 fusion protein (micro-BCR breakpoint) which is rarely seen in chronic myeloid leukemia (CML) patients. Here we report three patients with p230 fusion protein presenting with different cli nical presentations and diagnosed as CML-CP. These patients received Imatinib (tyrosine kinase inhibitor-TKI) and are still in remission. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - December 14, 2016 Category: Pathology Authors: Sudha Sazawal, Sunita Chikkara, Kanwaljeet Singh, Rekha Chaubey, Dinesh Chandra, Pravas Mishra, Manoranjan Mahapatra, Tulika Seth, Renu Saxena Source Type: research
Heat shock proteins HSP90, HSP70 and GRP78 expression in medullary thyroid carcinoma
Medullary thyroid carcinoma management consists mainly of surgical resection and is largely chemoresistant. There is ongoing effort to discover novel therapies for medullary thyroid carcinoma. Increased levels of heat shock proteins have been associated with multiple cancers and are being studied as potential therapeutic targets. The purpose of this study was to determine the expression levels ofheat shock proteins 90 and 70 and of glucose related protein 78 in medullary thyroid carcinoma tissues compared with normal thyroid tissues. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - November 29, 2016 Category: Pathology Authors: Ethan Soudry, Sagit Stern Shavit, Britta Hardy, Sarah Morgenstern, Tuvia Hadar, Raphael Feinmesser Source Type: research
Dedifferentiated chondrosarcoma of bone with prominent rhabdoid component
We present a case of dedifferentiated chondrosarcoma with rhabdomyosarcomatous differentiation harboring a prominent rh abdoid tumor component. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - November 23, 2016 Category: Pathology Authors: Matthew Stemm, Chad Beck, Rajeev Mannem, John Neilson, Michael J. Klein Source Type: research
Primary cutaneous spindle cell B cell lymphoma: A report of three cases and review of the literature
Primary cutaneous spindle cell lymphoma is a rare variant of primary cutaneous B-cell lymphoma (PCBCL). Herein, we present 3 cases of primary cutaneous spindle cell B cell lymphoma, 2 males and one female (age range 66 –76years). The patients presented with solitary skin lesions, distributed in the head and neck area and chest. The dominant cell size was in the intermediate to large cell size range. While the main cell type was a spindled one, other cells with a nuclear morphology quite typical for a centroblast were noted and as well careful inspection in the three cases revealed a focal residuum of germinal center-like...
Source: Annals of Diagnostic Pathology - November 22, 2016 Category: Pathology Authors: Cynthia M. Magro, Shabnam Momtahen Source Type: research
Expression of LEF1 in mantle cell lymphoma
Small lymphocytic lymphoma/chronic lymphocytic leukemia (CLL/SLL) and mantle cell lymphoma (MCL) usually are distinctly different in regard to clinical presentation, morphology, immunophenotype and molecular/genetic findings. In spite of this, select cases may show overlapping characteristics and represent a diagnostic challenge. Recently LEF1 staining was identified as a fairly characteristic finding in CLL/SLL, with positivity identified in up to 95% of cases. LEF1 staining has not been reported as being present in cases of MCL, making this stain a useful tool in distinguishing these diagnoses. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - November 21, 2016 Category: Pathology Authors: Dennis P. O'Malley, John P. Lee, Andrew M Bellizzi Source Type: research
Differentiated squamous intraepithelial lesion (dSIL)-like changes in the epidermis overlying anogenital melanocytic nevi: A diagnostic pitfall
Differentiated squamous intraepithelial lesion (dSIL) is morphologically and immunohistochemically analogous in the whole anogenital region. dSIL is a premalignant lesion frequently misinterpreted histopathologically as a benign dermatosis. The authors describe a peculiar change in the basal cell layer of the epidermis/epithelium overlying anogenital melanocytic nevi that may histopathologically imitate dSIL. The aim of this study is to familiarize the pathologists with this pitfall to avoid its possible overdiagnosis as dysplasia. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - November 13, 2016 Category: Pathology Authors: Kvetoslava Michalova, Dmitry V. Kazakov, Michael Michal, Ladislav Hadravsky, Denisa Kacerovska, Boris Rychly, Marketa Miesbauerova, Michal Michal Source Type: research
The correlation of the standard 5 probe FISH assay with melanocytic tumors of uncertain malignant potential
FISH has recently emerged as a technique to better assess the malignant potential of histologically ambiguous melanocytic lesions. However, the usefulness of FISH has not been conclusively established. The purpose of this study was to further explore the diagnostic value of FISH in distinguishing the borderline melanocytic tumor (BMT) from melanoma. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - November 8, 2016 Category: Pathology Authors: Aaron Muhlbauer, Shabnam Momtahen, Martin C. Mihm, James Wang, Cynthia M Magro Source Type: research
Myofibroblasts and mast cells: influences on biological behavior of odontogenic lesions
This study aimed to evaluate the presence of myofibroblasts and mast cells in odontogenic lesions. Sample consisted of 20 cases each of dentigerous cysts, odontogenic keratocysts, and solid ameloblastomas. Histological sections were submitted to immunohistochemistry using anti- α-SMA and anti-tryptase antibodies. Myofibroblasts and mast cells were counted at 400× magnification in 5 and 10 fields, respectively. Myofibroblasts were more frequent in ameloblastomas (24.41), followed by odontogenic keratocysts (16.21) and dentigerous cysts (11.85) (P=.002). (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - November 8, 2016 Category: Pathology Authors: Joabe dos Santos Pereira, Fernando Jos é de Oliveira Nóbrega, Rodrigo Gadelha Vasconcelos, Adriana Costa de Souza Martins Câmara, Lélia Batista de Souza, Lélia Maria Guedes Queiroz Tags: Original Contributions Source Type: research
Re: Immunoexpression of p53 in cutaneous and subcutaneous leiomyosarcomas
I have read, with much interest, the paper of Flores-Fernandez and Monteagudo [1] on immunoexpression of p53 in cutaneous and subcutaneous leiomyosarcomas. Nevertheless, I would like to make two comments. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - October 26, 2016 Category: Pathology Authors: David Creytens Source Type: research
Answer to “Immunoexpression of p53 in cutaneous and subcutaneous leiomyosarcomas”
We appreciate the comments of Dr. Creytens on our paper but we strongly believethat the debate on the prognosis, and therefore on terminology, of cutaneous smooth muscle tumors is still open. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - October 26, 2016 Category: Pathology Authors: Angel Fernandez-Flores, Carlos Monteagudo Source Type: research
Usefulness of p16/CDKN2A fluorescence in situ hybridization and BAP1 immunohistochemistry for the diagnosis of biphasic mesothelioma
Malignant mesothelioma is a highly aggressive neoplasm, and the histologic subtype is one of the most reliable prognostic factors. Some biphasic mesotheliomas are difficult to distinguish from epithelioid mesotheliomas with atypical fibrous stroma. The aim of this study was to analyze p16/CDKN2A deletions in mesotheliomas by fluorescence in situ hybridization (FISH) and BAP1 immunohistochemistry to evaluate their potential role in the diagnosis of biphasic mesothelioma. We collected 38 cases of pleural mesotheliomas. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - October 21, 2016 Category: Pathology Authors: Di Wu, Kenzo Hiroshima, Toshikazu Yusa, Daisuke Ozaki, Eitetsu Koh, Yasuo Sekine, Shinji Matsumoto, Kazuki Nabeshima, Ayuko Sato, Tohru Tsujimura, Hisami Yamakawa, Yuji Tada, Hideaki Shimada, Masatoshi Tagawa Source Type: research
Usefulness of p16/CDKN2A FISH and BAP1 Immunohistochemistry for the Diagnosis of Biphasic Mesothelioma
Malignant mesothelioma is a highly aggressive neoplasm, and the histological subtype is one of the most reliable prognostic factors. Some biphasic mesotheliomas are difficult to distinguish from epithelioid mesotheliomas with atypical fibrous stroma. The aim of this study was to analyze p16/CDKN2A deletions in mesotheliomas by fluorescence in situ hybridization (FISH) and BAP1 immunohistochemistry to evaluate their potential role in the diagnosis of biphasic mesothelioma. We collected 38 cases of pleural mesotheliomas. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - October 21, 2016 Category: Pathology Authors: Di Wu, Kenzo Hiroshima, Toshikazu Yusa, Daisuke Ozaki, Eitetsu Koh, Yasuo Sekine, Shinji Matsumoto, Kazuki Nabeshima, Ayuko Sato, Tohru Tsujimura, Hisami Yamakawa, Yuji Tada, Hideaki Shimada, Masatoshi Tagawa Source Type: research
SMARCA4 and SMARCA2 deficiency in non –small cell lung cancer: immunohistochemical survey of 316 consecutive specimens
The chromatin remodeling switch sucrose nonfermentable (SWI/SNF) complex has been increasingly implicated in the pathogenesis and dedifferentiation of neoplasms from several organs with prognostic and potential therapeutic implications. We herein investigated the expression of the SWI/SNF complex catalytic subunits SMARCA4 (BRG1) and SMARCA2 (BRM) in 316 consecutive non-small cell lung cancer (NSCLC) specimens on tissue microarrays (171 adenocarcinomas [ADCAs], 130 squamous cell carcinomas [SCCs], 9 adenosquamous carcinomas, and 6 large cell carcinomas) excluding undifferentiated/giant cell or rhabdoid carcinomas. (Source:...
Source: Annals of Diagnostic Pathology - October 19, 2016 Category: Pathology Authors: Esther Herpel, Ralf J. Rieker, Hendrik Dienemann, Thomas Muley, Michael Meister, Arndt Hartmann, Arne Warth, Abbas Agaimy Source Type: research
