SMARCA4 and SMARCA2 Deficiency in Non-small Cell Lung Cancer: Immunohistochemical Survey of 316 Consecutive Specimens
The chromatin remodeling Switch Sucrose Non-Fermentable (SWI/SNF) complex has been increasingly implicated in the pathogenesis and dedifferentiation of neoplasms from several organs with prognostic and potential therapeutic implications. We herein investigated the expression of the SWI/SNF complex catalytic subunits SMARCA4 (BRG1) and SMARCA2 (BRM) in 316 consecutive NSCLC specimens on tissue microarrays (171 adenocarcinomas/ADCA, 130 squamous cell carcinomas/SCC, 9 adenosquamous carcinomas, and 6 large cell carcinomas) excluding undifferentiated/giant cell or rhabdoid carcinomas. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - October 19, 2016 Category: Pathology Authors: Esther Herpel, Ralf J. Rieker, Hendrik Dienemann, Thomas Muley, Michael Meister, Arndt Hartmann, Arne Warth, Abbas Agaimy Source Type: research
Hepatosplenic T-cell Lymphoma Arising in Patients with Immunodysregulatory Disorders: A Study of 7 Patients Who Did Not Receive TNF- α Inhibitor Therapy and Literature Review
Hepatosplenic T-cell lymphoma (HSTCL) is a rare and aggressive extranodal T-cell lymphoma that can arise in patients with underlying immune disorders. Others have suggested that tumor necrosis factor alpha (TNF- α) inhibitor therapy for immune disorders increases the risk of HSTCL. To assess for a potential relationship between HSTCL and the use of TNF-α inhibitors, we searched for patients with HSTCL and underlying immune disorders at our institution. We identified 7 patients with a median age of 38 year s. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - October 17, 2016 Category: Pathology Authors: Mariko Yabe, L. Jeffrey Medeiros, Yahya Daneshbod, Masoud Davanlou, Carlos E. Bueso-Ramos, Elisa J. Moran, Ken H. Young, Roberto N. Miranda Source Type: research
Epithelial downgrowth. Report of 2 cases diagnosed by ocular biopsy
Epithelial downgrowth is an uncommon complication of ocular surgery or adverse consequence of accidental trauma, caused by surface squamous epithelium that has gained access to the inner compartments of the eye. Once embedded in the eye, squamous epithelium spreads over contiguous structures, interfering with normal aqueous outflow and vision. The pursuit of improved therapies is ongoing, but the greatest chance of preventing blindness is with early recognition. Two cases of epithelial downgrowth diagnosed from a corneal button and an iris biopsy are presented to familiarize pathologists with this disorder. (Source: Annals...
Source: Annals of Diagnostic Pathology - October 13, 2016 Category: Pathology Authors: Hershel R. Patel, Curtis E. Margo Tags: Review Article Source Type: research
Epithelial Downgrowth
Epithelial downgrowth is an uncommon complication of ocular surgery or adverse consequence of accidental trauma, caused by surface squamous epithelium that has gained access to the inner compartments of the eye. Once embedded in the eye, squamous epithelium spreads over contiguous structures, interfering with normal aqueous outflow and vision. The pursuit of improved therapies is ongoing, but the greatest chance of preventing blindness is with early recognition. Two cases of epithelial downgrowth diagnosed from a corneal button and an iris biopsy are presented to familiarize pathologists with this disorder. (Source: Annals...
Source: Annals of Diagnostic Pathology - October 13, 2016 Category: Pathology Authors: Hershel R. Patel, Curtis E. Margo Source Type: research
Signet-ring cell lymphoma: clinicopathologic, immunohistochemical, and fluorescence in situ hybridization studies of 7 cases
Signet-ring cell lymphoma (SRCL) is a rare morphologic variant of non –Hodgkin lymphoma. Although it was initially reported as a rare morphologic variant of follicular lymphoma (FL), SRCL has to date been described in most types of non–Hodgkin lymphoma, mostly as single-case reports. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - October 6, 2016 Category: Pathology Authors: Shanxiang Zhang, Jihong Sun, Yanan Fang, Mehdi Nassiri, Lanting Liu, Jiehao Zhou, Ryan Stohler, Haki Choi, Gail H Vance Source Type: research
Cyclin D1 expression and polysomy in lymphocyte-predominant cells of nodular lymphocyte-predominant Hodgkin lymphoma
Cyclin D1 protein expression in lymphocytes is classically associated with mantle cell lymphoma. Although increasingly recognized in other lymphoproliferative disorders, cyclin D1 expression and CCND1 gene abnormalities have not been well studied in nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL). Using a double stain for CD20/cyclin D1, we quantified cyclin D1 expression in 10 cases of NLPHL and correlated those findings with SOX11 expression, CCND1 gene abnormalities, and clinical data. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - October 6, 2016 Category: Pathology Authors: Benjamin B. Cho, Sarah M. Kelting, Alejandro A. Gru, Robin D. LeGallo, Patcharin Pramoonjago, Teresa A. Goldin, Christopher T. Heitz, Nadine S. Aguilera Tags: Original Contribution Source Type: research
Signet ring cell lymphoma: Clinicopathologic, immunohistochemical and FISH studies of seven cases
Signet ring cell lymphoma (SRCL) is a rare morphologic variant of non-Hodgkin lymphoma (NHL). The lymphoma cells typically contain abundant cytoplasmic inclusions and the nuclei may be displaced to the periphery of the cells. While it was initially reported as a rare morphologic variant of follicular lymphoma (FL), [1]SRCL has to date been described in majority types of NHL, mostly as single case reports and including both cutaneous and systemic NHL, such as FL, small lymphocytic lymphoma, lymphoplasmacytic lymphoma, marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma), diffuse large B-cell lymphoma ...
Source: Annals of Diagnostic Pathology - October 6, 2016 Category: Pathology Authors: Shanxiang Zhang, Jihong Sun, Yanan Fang, Mehdi Nassiri, Lanting Liu, Jiehao Zhou, Ryan Stohler, Haki Choi, Gail H Vance Source Type: research
Cyclin D1 expression and polysomy in LP cells of nodular lymphocyte predominant Hodgkin lymphoma
Cyclin D1 protein expression in lymphocytes is classically associated with mantle cell lymphoma. While increasingly recognized in other lymphoproliferative disorders, cyclin D1 expression and CCND1 gene abnormalities have not been well-studied in nodular lymphocyte predominant Hodgkin lymphoma (NLPHL). Using a double stain for CD20/cyclin D1, we quantified cyclin D1 expression in 10 cases of NLPHL and correlated those findings with SOX11 expression, CCND1 gene abnormalities and clinical data. For comparison, we examined five cases of T cell/histiocyte-rich large B-cell lymphoma (THRLBCL). (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - October 6, 2016 Category: Pathology Authors: Benjamin B. Cho, Sarah M. Kelting, Alejandro A. Gru, Robin D. LeGallo, Patcharin Pramoonjago, Teresa A. Goldin, Christopher T. Heitz, Nadine S. Aguilera Tags: Original Contributions Source Type: research
Gastric mucosal status susceptible to lanthanum deposition in patients treated with dialysis and lanthanum carbonate
Lanthanum carbonate is a popular chemical which is administered for patients with end-stage kidney disease to reduce the absorption of phosphate, and lanthanum deposition in the gastrododenal mucosa has recently been reported. The aim of this study was to assess whether any histologic changes of the gastric mucosa are related to the deposition of lanthanum. 24 patients who revealed the histology of lanthanum deposition on gastroduodenal biopsy between 2011 and 2014 were included in the study, and their clinical records and gastroduodenal biopsies obtained from 2011 to 2015 were reviewed, adding the review of gastroduodenal...
Source: Annals of Diagnostic Pathology - October 4, 2016 Category: Pathology Authors: Shinichi Ban, Syunji Suzuki, Kenji Kubota, Susumu Ohshima, Hideaki Satoh, Hiroki Imada, Yoshihiko Ueda Source Type: research
Ameloblastoma vs basal cell carcinoma: an immunohistochemical comparison
This study aims to appraise the current allocation of AB in the classification through an immunohistochemical comparison of some aspects of behavior with BCC. Sections from retrospectively retrieved formalin-fixed, paraffin-embedded tissue blocks of AB (n = 37) and BCC (n = 34) were comparatively examined for the immunohistochemical expression for Ki-67, Bcl-2, MMP-2, MMP-9, CD31, and D2-40 monoclonal antibodies. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - September 25, 2016 Category: Pathology Authors: Salam N. Jawad, Bashar H. Abdullah Source Type: research
False-positive results in diagnostic immunohistochemistry are related to horseradish peroxidase conjugates in commercially available assays
False-positive results in diagnostic immunopathology can lead to unnecessary treatments. The purpose of this study was to do a side-by-side comparison of 10 different antibodies commonly used in the clinical laboratory altering only the horseradish peroxidase (HRP) conjugate. The automated Leica BOND-MAX platform was used to study serial sections from 203 tissues including controls compared in a blinded fashion using the HRP conjugates from Leica (Refine HRP), Ventana Medical Systems (Ultraview HRP), and Enzo Life Sciences (Polyview HRP). (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - September 25, 2016 Category: Pathology Authors: Gerard Nuovo Source Type: research
A comparison of cancer stem cell markers and nonclassical major histocompatibility complex antigens in colorectal tumor and noncancerous tissues
Colorectal carcinoma (CRC) is one of the most fatal types of cancer in both women and men, and, unfortunately, patients are often diagnosed at an advanced stage. Cancer stem cells (CSCs) are associated with poor prognosis, metastasis, and recurrence, as well as chemotherapy and radiotherapy resistance. Therefore, different treatment alternatives are needed to facilitate the elimination of CSCs. One such approach is immunotherapy; however, tumor cells can evade immune cells by alteration of the expression patterns of human leukocyte antigens (HLA). (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - September 25, 2016 Category: Pathology Authors: Rabia Bilge Özgül Özdemir, Alper Tunga Özdemir, Fatih Oltulu, Kamile Kurt, Gürkan Yiğittürk, Cengiz Kırmaz Source Type: research
Dermatofibrosarcoma protuberans: pathology, genetics, and potential therapeutic strategies
Dermatofibrosarcoma protuberans (DFSP), the most common dermal sarcoma, is a malignant fibroblastic tumor most frequently arising in middle-aged adults. It is typically a low-grade sarcoma that grows slowly but has a high rate of local recurrence with low metastatic potential. Dermatofibrosarcoma protuberans is characterized by a specific translocation t(17;22)(q22;q13) leading to the formation of COL1A1-PDGFB fusion transcripts. Histologically, DFSP has characteristic morphology, of storiform islands of bland spindle cells, and immunohistochemically, it shows diffuse expression of CD34. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - September 25, 2016 Category: Pathology Authors: Khin Thway, Jonathan Noujaim, Robin L Jones, Cyril Fisher Source Type: research
Correlation of microvessel parameters in invasive ductal carcinoma of the breast and fibroadenomas: a morphometric study
Modifications of microvascular configuration are essential features encountered during the progression of breast tumors. Our objectives were to correlate morphometrically evaluated microvessel parameters (microvessel density [MVD], microvessel caliber [VC], microvessel cross-sectional area [VCSA], percentage of total VCSA [%TVCSA], and total microvessel boundary density [TVBD]) with histologic grades of invasive ductal carcinoma (IDC) of the breast and benign breast lesions. Sixty cases of IDC presented with modified radical mastectomy, and 20 benign breast fibroadenomas were evaluated for various microvessel parameters, u...
Source: Annals of Diagnostic Pathology - September 25, 2016 Category: Pathology Authors: Dibyajyoti Boruah, Jasvinder K Bhatia, Abhishek Rai, V. Srinivas, V.S. Nijhawan Source Type: research
False positive results in diagnostic immunohistochemistry are related to horseradish peroxidase conjugates in commercially available assays
False positive results in diagnostic immunopathology can lead to unnecessary treatments. The purpose of this study was to do a side-by-side comparison of ten different antibodies commonly used in the clinical laboratory altering only the horseradish peroxidase (HRP) conjugate. The automated Leica BOND-MAX platform was used to study serial sections from 203 tissues including controls compared in a blinded fashion using the HRP conjugates from Leica (Refine HRP), Ventana Medical Systems (Ultraview HRP), and Enzo Life Sciences (Polyview HRP). (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - September 25, 2016 Category: Pathology Authors: Gerard Nuovo Source Type: research
