Differential expression of epithelial cell adhesion molecule (EpCAM) in salivary gland neoplasms
EpCAM is the epithelial-specific molecule expressed on various epithelial cell types. The function of EpCAM involves cellular adhesion, proliferation and signalling in both normal tissues and cancers. The purposes of this study were to investigate the EpCAM expression in salivary gland neoplasms and examine its relationship with pathologic characteristics. Forty-two cases of salivary gland neoplasms, including 20 mucoepidermoid carcinomas (MEC), 11 adenoid cystic carcinomas (ACC), 9 pleomorphic adenomas (PA) and 2 polymorphous low-grade adenocarcinomas (PLGA) were enrolled. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - August 15, 2016 Category: Pathology Authors: Ekarat Phattarataratip, Marisa Masorn, Werapong Jarupoonphol, Sirinpaporn Supatthanayut, Pichanee Saeoweiang Source Type: research
Re: Mammary analogue secretory carcinoma of salivary glands: a clinicopathologic study of 11 cases
Dear Editor-in-Chief, (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - August 15, 2016 Category: Pathology Authors: Bacem A.E. O Khalele Source Type: research
An isolated inflammatory myofibroblastic tumor of adrenal gland
Inflammatory myofibroblastic tumor (IMT) is an uncommon lesion that shows a wide range of anatomic distribution. The adrenal gland, however, is a distinctly rare site of occurrence. To date, only a few cases of IMT arising in the adrenal gland have been reported in the English literature. Here, we report another case of isolated adrenal IMT.A 34-year-old man presented to the emergency department with a complaint of a sudden severe right-sided back pain. Subsequent computed tomographic scan imaging studies demonstrated a large right adrenal mass associated with a hematoma. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - August 11, 2016 Category: Pathology Authors: Ghadah Al Sannaa, Jana L. Wimmer, Alberto G. Ayala, Jae Y. Ro Source Type: research
Skin aging in patients with acquired immunodeficiency syndrome
To evaluate the histomorphometric skin changes over aging patients with autopsied acquired immunodeficiency syndrome (AIDS). In 29 skin fragments of autopsied elderly (older than 50 years) and nonelderly patients with AIDS, epidermal thickness, the number of layers, the diameter of cells, the percentage of collagen and elastic fibers in the dermis, and the number and morphology of Langerhans cells were assessed. Statistical analysis was performed by SigmaStat 2.03 program. The thickness of the epidermis (92.55 × 158.94 μm), the number of layers (7 × 9 layers), and the diameter of the cells (13.27 × 17.6 μm) were stati...
Source: Annals of Diagnostic Pathology - August 11, 2016 Category: Pathology Authors: Grace Kelly Naves de Aquino Favarato, Aline Cristina Souza da Silva, L ívia Ferreira Oliveira, Mara Lúcia da Fonseca Ferraz, Vicente de Paula Antunes Teixeira, Camila Lourencini Cavellani Source Type: research
Skin aging in AIDS patients
To evaluate the histomorphometric skin changes over aging patients with autopsied AIDS. In 29 skin fragments of autopsied elderly patients (aged over 50) and non-elderly with AIDS was assessed epidermal thickness, the number of layers and the diameter of cells and the percentage of collagen and elastic fibers in the dermis, number and morphology of Langerhans cells (LC). Statistical analysis was performed by SigmaStat ® 2.03 program. The thickness of the epidermis (92.55 x 158.94 μm), the number of layers (7 x 9 layers) and the diameter of the cells (13.27 x 17.6 μm) were statistically lower among the elderly. (Source: ...
Source: Annals of Diagnostic Pathology - August 11, 2016 Category: Pathology Authors: Grace Kelly Naves de Aquino Favarato, Aline Cristina Souza da Silva, L ívia Ferreira Oliveira, Mara Lúcia da Fonseca Ferraz, Vicente de Paula Antunes Teixeira, Camila Lourencini Cavellani Source Type: research
An Isolated Inflammatory Myofibroblastic Tumor of Adrenal Gland: Case Report and Review of Literature
Inflammatory myofibroblastic tumor (IMT) is an uncommon mesenchymal proliferation that demonstrates evidence of myofibroblastic / fibroblastic differentiation. It is characterized by the presence of variable component of inflammatory cells [1]. Since its initial recognition in the lung, cases of IMT have been described in various anatomic locations [2]. The adrenal gland, however, is a distinctly rare site of occurrence. To the best of our knowledge, only a few cases of IMT arising in the adrenal gland have been reported in the English literature [3-7]. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - August 11, 2016 Category: Pathology Authors: Ghadah Al Sannaa, Jana L. Wimmer, Alberto G. Ayala, Jae Y. Ro Source Type: research
Primary Cardiac Diffuse Large B-cell Lymphoma in Immunocompetent Patients: Clinical, Histologic, Immunophenotypic and Genotypic Features of 3 cases
This study describes the clinical, histologic / cytologic, immunophenotypic, and molecular genetic findings for 3 immunocompetent patients with primary cardiac diffuse large B-cell lymphoma. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - August 11, 2016 Category: Pathology Authors: Gwyneth Soon, Guan Wei Ow, Hian Li Chan, Siok Bian Ng, Shi Wang Source Type: research
Expression analysis of BRUCE protein in esophageal squamous cell carcinoma
Apoptosis is a form of cell death in response to diverse stressful physiological or pathological stimuli. One of the most important gene families involved in apoptosis is inhibitors of apoptosis (IAPs). As a member of IAPs, BRUCE can suppress apoptosis and promote cell division. Because esophageal squamous cell carcinoma (ESCC) cells, as well as other cancer cells, are immortal, our aim in this study was to analyze BRUCE protein expression in ESCC and evaluate its correlation with tumoral clinicopathological features. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - August 10, 2016 Category: Pathology Authors: Somayeh Salehi, Amir Hosein Jafarian, Mohammad Mahdi Forghanifard Source Type: research
Frozen Section Evaluation of Margins in Radical Prostatectomy Specimens: A Contemporary Study and Literature Review
The utility of routine frozen section (FS) analysis for margin evaluation during radical prostatectomy (RP) remains controversial. A retrospective search was conducted to identify RPs evaluated by FS over a 5-year period. The potential of FS to discriminate between benign and malignant tissue, and predict final margins was evaluated. During the study period, 71/575 (12.3%) cases underwent FS evaluation of margins, generating 192 individual FSs. Eight FSs were diagnosed as atypical/indeterminate because of significant freezing, crushing and/or thermal artifacts, 11 as positive for carcinoma, and 173 as benign. (Source: Anna...
Source: Annals of Diagnostic Pathology - August 8, 2016 Category: Pathology Authors: Amberly L. Nunez, Giovanna A. Giannico, Faisal Mukhtar, Virginia Dailey, Rizk El-Galley, Omar Hameed Source Type: research
Cutaneous Myeloid Dendritic Cell dyscrasia: A Cutaneous Clonal Monocytosis Associated with Chronic Myeloproliferative Disorders and Peripheral Blood Monocytosis
Monocytes are critical components of the innate immune system and they can differentiate into dendritic cells (DCs). Cutaneous neoplasms of dendritic cell origin are uncommon and mostly represented by histiocytic lesions derived primarily from Langerhans cells. The myeloid DC (mDC) while recognized in the immunology literature does not have a well-defined neoplastic cutaneous counterpart. Eleven patients with a diagnosis of cutaneous mDC dyscrasia were evaluated. Routine hematoxylin and eosin stain were performed followed by selective phenotypic studies. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - August 3, 2016 Category: Pathology Authors: Cynthia M. Magro, Shabnam Momtahen, Shalini Verma, Ronnie M. Abraham, Constantin Friedman, Gerard J. Nuovo, Wayne Tam Source Type: research
Spinal osteoblastic meningioma with hematopoiesis: radiologic-pathologic correlation and review of the literature
We describe a case report of a woman who presented with back pain and an isolated event of urinary incontinence. A calcified spinal canal mass at T8 was identified on computed tomographic and magnetic resonance imaging. A gross total resection of the tumor was performed and pathologic examination showed a meningioma, World Health Organization grade 1, containing bone and bone marrow elements. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - August 1, 2016 Category: Pathology Authors: Elizabeth J. Cochran, Abraham Schlauderaff, Scott D. Rand, Gerald W. Eckardt, Shekar Kurpad Source Type: research
Spinal osteoblastic meningioma with hematopoiesis: radiological-pathological correlation and review of the literature
We describe a case report of a woman who presented with back pain and an isolated event of urinary incontinence. A calcified spinal canal mass at T8 was identified on CT and MR imaging. A gross total resection of the tumor was performed and pathologic examination showed a meningioma, WHO grade 1, containing bone and bone marrow elements. A review of previously reported cases and a discussion of possible mechanisms of bone and hematopoiesis development in meningioma are presented. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - August 1, 2016 Category: Pathology Authors: Elizabeth J. Cochran, Abraham Schlauderaff, Scott D. Rand, Gerald W. Eckardt, Shekar Kurpad Tags: Original Contributions Source Type: research
Inflammation and Focal Atrophy in Prostate Needle Biopsy Cores and Association to Prostatic Adenocarcinoma
The possible origin of proliferative inflammatory atrophy in the regenerative proliferation of prostate epithelial cells in response to injury caused by inflammation, and their relation to prostate adenocarcinoma has not been defined. Inflammation and focal atrophy are common pathological findings in prostate biopsies, currently not routinely included in surgical pathology reports. To determine the correlation between inflammation and focal atrophy with prostate adenocarcinoma. Prostate needle biopsies from 203 patients with clinical parameters suspicious for malignancy were evaluated for the presence and extent of chronic...
Source: Annals of Diagnostic Pathology - July 19, 2016 Category: Pathology Authors: Ines Benedetti, Alfonso Bettin, Niradiz Reyes Source Type: research
Surgical follow-up results for apocrine adenosis and atypical apocrine adenosis diagnosed on breast core biopsy
This study aimed to determine the frequency of carcinoma on follow-up excision in patients with a diagnosis of AA or AAA on core biopsy. Forty-one breast core biopsies of AA (n=29) and AAA (n=12) were identified during a study period of 12 years. Of the 41 core biopsies with AA or AAA, 10 biopsies showed coexisting/concurrent atypical hyperplasia or carcinoma. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - July 10, 2016 Category: Pathology Authors: Yanjun Hou, Shweta Chaudhary, Faye F. Gao, Zaibo Li Source Type: research
