AMPK expression patterns are significantly associated with poor prognosis in breast cancer patients
Many investigators have examined the functions of AMP-activated protein kinase (AMPK) in cancer biology and its anti-neoplastic features in cancer models. The goal of this research is to assess the association of the immunohistochemical expression of AMPK in human mammary tumours with the clinical data of breast cancer patients. 449 cases of previously diagnosed breast cancer, and 27 tissue samples of fibroadenomas and normal breast were utilized for detection of AMPK expression using tissue microarrays and immunohistochemistry. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - May 16, 2017 Category: Pathology Authors: Jaudah Al-Maghrabi, Kaltoom Al-Sakkaf, Imtiaz Ahmad Qureshi, Nadeem Shafique Butt, Lila Damnhory, Mohamed Elshal, Basim Al-Maghrabi, Alia Aldahlawi, Sawsan Ashoor, Barry Brown, Pauline Dobson, Mohamad Nidal Khabaz Source Type: research
Usefulness of a direct immunofluorescence in the diagnosis of plaque type oral lichen planus
Oral lichen planus (OLP) is a chronic inflammatory condition of unknown etiology, affecting 0.5 to 2% of the world population [1]. It most frequently affects women aged 40 to 60years [2-7], though it can also present in young adults and children [8-11]. Despite advances in the knowledge about the etiopathogenesis of OLP, there are no conclusive studies on the etiological factors and triggering mechanisms involved in the disease. There is evidence that OLP is a T-lymphocyte (CD4+ and CD8+) mediated immunological process triggered by an unidentified antigen, that alters the basal keratinocytes of the oral mucosa, causing les...
Source: Annals of Diagnostic Pathology - May 16, 2017 Category: Pathology Authors: Patricia Alejandra Masquijo-Bisio, Mariana Silvia Gandolfo, Alicia Keszler, Maria Elina Itoiz, Mar ía Luisa Paparella Source Type: research
Utility of different immunostains for diagnosis of metastatic breast carcinomas in both surgical and cytological specimens
In this study, we aimed to compare the performance of these immunostains in the work up of metastatic breast carcinoma in both surgical and cytological specimens. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - May 16, 2017 Category: Pathology Authors: Yanjun Hou, Rulong Shen, Shweta Chaudhary, Dena Tonkovich, Zaibo Li Source Type: research
Dedifferentiated chondrosarcoma of the larynx: Radiological, gross, microscopic and clinical features
Laryngeal chondrosarcoma is an uncommon malignancy with a predilection for the cricoid cartilage of adult male patients. Although rare, identification of aggressive chondrosarcoma variants, such as dedifferentiated chondrosarcoma (DDCS) may influence preoperative patient counseling, definitive surgical management, potential implementation of post-operative adjuvant therapy and prognosis. Herein we describe clinical and imaging features of laryngeal DDCS, the unique perspective of fresh and formalin fixed macroscopic examination, a spectrum of histopathologic findings, and detail the full course of the patient's disease. (S...
Source: Annals of Diagnostic Pathology - May 16, 2017 Category: Pathology Authors: Kelly R. Magliocca, Mark A. Edgar, Amanda Corey, Craig R. Villari Source Type: research
Chronic inflammation in refractory hippocampal sclerosis-related temporal lobe epilepsy
Emerging evidence suggests chronic inflammation may play a role in hippocampal sclerosis-associated temporal lobe epilepsy. We sought to systematically evaluate for its presence in a group of 315 patients who underwent surgery for medically-refractory epilepsy and who had hippocampal sclerosis. Upon histologic review of hematoxylin and eosin stained tissue sections, 95 (41%) cases demonstrated the presence of lymphocytes within the perivascular region and diffusely within the brain parenchyma. Those cases with chronic inflammation evident on hematoxylin and eosin staining were significantly more likely to experience a post...
Source: Annals of Diagnostic Pathology - May 16, 2017 Category: Pathology Authors: Jordan M. Gales, Richard A. Prayson Tags: Review Article Source Type: research
Expression of pRb, Ki67 and HER 2/neu in gastric carcinomas: Relation to different histopathological grades and stages
Gastric carcinoma is one of the most aggressive malignancies, and is the fifth most common malignancy worldwide [1]. It is the second leading cause of cancer related mortality worldwide although in the past few years there has been an evident decrease in incidence in Western countries [2,3]. More than 70% of gastric carcinoma occurs in developing countries. The highest incidence was reported in middle and Far East [4]. Currently, three East Asia countries: China, Japan and Korea account for 60% of total cases [5]. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - May 12, 2017 Category: Pathology Authors: Azza Abdel-Aziz, Rehab Allah Ahmed, Afaf Ibrahiem Source Type: research
Distribution of lymphoid neoplasms in Northwest China: Analysis of 3244 cases according to WHO classification in a single institution
To explore the distribution of lymphoid neoplasms in Northwest China, the clinical and pathological data of lymphoma patients from 2006 to 2014 were analyzed according to the WHO classification in Xijing Hospital. Of the 3244 cases, mature B-cell neoplasms occupied 60.7%, while mature T/NK-cell neoplasms and Hodgkin's lymphomas (HL) occupied 26.2% and 8.1%, respectively. The most common subtype of lymphoma was diffuse large B-cell lymphoma (35.0%), followed by extranodal NK/T-cell lymphoma, nasal type (ENKTCL) (12.9%) and marginal zone B-cell lymphoma (7.8%). (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - May 12, 2017 Category: Pathology Authors: Chun Cao, Juan Feng, Hongtao Gu, Hailong Tang, Li Xu, Hongjuan Dong, Baoxia Dong, Mimi Shu, Qingxian Bai, Rong Liang, Tao Zhang, Lan Yang, Zhe Wang, Xiequn Chen, Guangxun Gao Source Type: research
Expression of dog1 in low-grade fibromyxoid sarcoma: A study of 19 cases and review of the literature
DOG1 is a highly-sensitive marker often included in the immunohistochemical panel for the diagnosis of gastrointestinal stromal tumors (GISTs). Recent research has shown that DOG1 may also be expressed by low-grade fibromyxoid sarcomas (LGFMSs); this may give rise to diagnostic error when the sarcoma is located in the abdominal cavity. This paper reports on immnohistochemical expression of DOG1 in 19 LGFMSs using two different monoclonal antibodies: K9 (Leica, Novocastra Laboratories, Newcastle upon Tyne, UK) and SP31 (Thermo Scientific, Freemont, USA). (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - May 11, 2017 Category: Pathology Authors: Ana Vallejo-Ben ítez, Enrique Rodríguez-Zarco, Sara Pabón Carrasco, Sofia Pereira-Gallardo, Javier Brugal Molina, Antonio García-Escudero, Antonio Robles Frías, David Marcilla, Ricardo González-Cámpora Source Type: research
Pituicytoma: Review of commonalities and distinguishing features among TTF-1 positive tumors of the central nervous system
Pituicytoma is a rare low-grade glial neoplasm that originates in the distribution of the neurohypophysis, including the posterior pituitary lobe and infundibular stalk. The tumor cells resemble pituicytes, which are specialized glial cells of the neurohypophysis. Pituicytoma can be misdiagnosed pre-operatively as a pituitary adenoma due to overlapping clinical and neuroimaging features between these two entities. Pituicytoma can also mimic other neoplasms of the sellar and parasellar regions microscopically – meningioma, schwannoma and pilocytic astrocytoma – and shares immunohistochemical expression of TTF-1 with spi...
Source: Annals of Diagnostic Pathology - May 11, 2017 Category: Pathology Authors: Siba El Hussein, Cristina Vincentelli Source Type: research
Accuracy and interobserver agreement of retroareolar frozen sections in nipple-sparing mastectomies
In the last decades, surgical treatment of breast cancer has enormously changed. As a result, nipple-sparing mastectomy (NSM) has evolved as an oncologically safe and cosmetic approach. NSM includes a subareolar frozen section to evaluate malignancy. We determined the accuracy of subareolar frozen section diagnosis, analyzed the discrepancy factor, and estimated the interobserver agreement of frozen section in NSM. A retrospective review of all NSMs at our institution from 2009 to 2015 was performed. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - May 3, 2017 Category: Pathology Authors: David Alfonso Suarez-Zamora, Luis Eduardo Barrera-Herrera, Mauricio Alfonso Palau-Lazaro, Fabio Torres-Franco, Alejandro Orozco-Plazas, Lisette Barreto-Hauzeur, Paula Andrea Rodriguez-Urrego Source Type: research
Primary collision tumors of the kidney composed of oncocytoma and papillary renal cell carcinoma: A review
There are well known cases of hybrid tumors of chromophobe renal cell carcinoma (RCC) and oncocytoma in kidney, where both tumors have the same cell of origin – intercalated cell of the collecting duct. However, collision tumors composed of neoplasms originating from different cell lineages such as oncocytoma and papillary RCC are extremely rare. Herein, we made a collective literature review of reported cases of collision tumors composed of oncocytoma and papillary RCC, adding a case that we recently experienced. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - April 29, 2017 Category: Pathology Authors: Zulfia McCroskey, Sue J. Sim, Andrew A. Selzman, Alberto G. Ayala, Jae Y. Ro Source Type: research
Unusual locations of hydatid disease: A 10-year experience from a tertiary reference center in Western Turkey
Hydatid disease is an endemic parasitic infection caused by Echinococcus granulosus mostly seen in the Mediterranean countries. The most affected organ is the liver, however hydatidosis can be found anywhere in the human body. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - April 28, 2017 Category: Pathology Authors: Eylul Gun, Demet Etit, Dilara O. Buyuktalanci, Fulya Cakalagaoglu Source Type: research
Ultrastructural examination of skin biopsies may assist in diagnosing mitochondrial cytopathy when muscle biopsies yield negative results
This study investigates how frequently skin biopsies reveal mitochondrial abnormalities, correlates skin and muscle biopsy findings, and describes clinical diagnoses rendered following the evaluation. A retrospective review of surgical pathology reports from 1990 to 2015 identified skin biopsies examined by electron microscopy for suspected metabolic disease. A total of 630 biopsies were included from 615 patients. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - April 28, 2017 Category: Pathology Authors: John L. McAfee, Christine B. Warren, Richard A. Prayson Source Type: research
Anisometric cell lipoma: Insight from a case series and review of the literature on adipocytic neoplasms in survivors of retinoblastoma suggest a role for RB1 loss and possible relationship to fat-predominant ( “fat-only”) spindle cell lipoma
The term “anisometric cell lipoma” (ACL) has been proposed recently by Evans for a lipoma variant characterized by striking variation in size and shape of adipocytes but little or no cytological atypia. One patient with multiple ACL had a history of retinoblastoma. The current study analyzed six patients with ACL (4 males and two females aged 34 to 87years; median, 58); all seen in consultation. Five patients presented with solitary and one with multiple subcutaneous masses measuring 5 to 9cm (median, 7.5cm). (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - April 28, 2017 Category: Pathology Authors: Abbas Agaimy Source Type: research
Molecular pathology diagnosis of diffuse large B cell lymphoma using BIOMED-2 clonal gene rearrangements
Clonality testing for immunoglobulin gene rearrangement analysis could be implemented effectively as a useful technique for conventional diagnosis of lymphoma. The European Biomedicine and Health Concerted Action Project BMH4-CT98-3936 (BIOMED-2) have been suggested a gold standard method to clonality detection. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - April 27, 2017 Category: Pathology Authors: Saeid Ghorbian Source Type: research
