Pattern of SMARCB1(INI1) and SMARCA4(BRG1) in Poorly Differentiated Endometrioid Adenocarcinoma of the Uterus: Analysis of a Series with Emphasis on a Novel SMARCA4-Deficient Dedifferentiated Rhabdoid Variant
Background: The role of the SWI/SNF chromatin remodelling complex in the initiation and progression of cancer is emerging. In the female genital tract, only ovarian small cell carcinoma, hypercalcemic type harbors recurrent inactivating SMARCA4 mutations. Otherwise, only rare case reports documented SMARCB1-involvement in endometrial cancer. Patients & Results: We analyzed 24 grade 3 uterine endometrioid adenocarcinomas and 2 undifferentiated carcinomas for immunohistochemical expression of SMARCB1 and SMARCA4. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - April 6, 2015 Category: Pathology Authors: Johanna Strehl, David L. Wachter, Jutta Fiedler, Engelbert Heimerl, Matthias W. Beckmann, Arndt Hartmann, Abbas Agaimy Tags: Original Contribution Source Type: research
Gene Protein Detection Platform – A comparison of a new HER2 assay with conventional immunohistochemistry and FISH platforms
Human Epidermal Growth Factor Receptor 2 (HER2) immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) are widely used semi quantitative assays for selecting breast cancer patients for HER2 antibody therapy. However, both techniques have been shown to have disadvantages. Our aim was to test a recent automated technique of combined IHC and bright field dual in situ hybridization (DISH) - Gene Protein Detection Platform (GPDP) in breast cancer HER2 protein, gene and chromosome 17-centromere (CEP17) status evaluations, comparing the results in accordance to the ASCO/CAP recommendations for HER2 testing in Br...
Source: Annals of Diagnostic Pathology - April 6, 2015 Category: Pathology Authors: Gustav Stålhammar, Pedro Farrajota, Ann Olsson, Cristina Silva, Johan Hartman, Göran Elmberger Tags: Original Contribution Source Type: research
Pulmonary capillary hemangiomatosis associated with connective tissue disease: a report of 4 cases and review of the literature
We describe 4 patients with CTD and PHTN unexpectedly found to have pulmonary capillary hemangiomatosis (PCH) at explant after lung transplantation or autopsy. Pulmonary capillary hemangiomatosis is defined as a proliferation of capillaries in alveolar walls and can clinically cause PHTN. We detail the pathologic findings of PCH, describe the differential diagnosis, and present a review of the literature on the possible association of PCH with CTD. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - March 21, 2015 Category: Pathology Authors: Shelley I. Odronic, Tathagat Narula, Marie Budev, Carol Farver Tags: Original Contribution Source Type: research
Pulmonary Capillary Hemangiomatosis Associated with Connective Tissue Disease: A Report of Four Cases and Review of the Literature
Pulmonary capillary hemangiomatosis (PCH) is a rare vascular proliferation of the septal capillaries. Although it was first described in 1978 [1], there have been fewer than 50 cases reported in the literature [2]. PCH has been described in patients ages 2 to 71, most frequently in young adults [2,3]. PCH is an established cause of clinically evident pulmonary hypertension (PHTN) and classically presents with hemoptysis and pleural effusions [3]. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - March 21, 2015 Category: Pathology Authors: Shelley I. Odronic, Tathagat Narula, Marie Budev, Carol Farver Tags: Original Contribution Source Type: research
Heterogeneity of Promoter Mutations Status in Squamous Cell Carcinomas of Different Anatomical Sites
Squamous cell carcinoma (SCC) can arise from different anatomic sites including skin, head & neck, lung, esophagus and genital area etc. Despite the same histopathological features and immunohistochemistry profile, the SCCs of different body sites can show tremendous differences in their presenting symptoms, risk factor associations, natural history, prognosis, and response to treatment. This may reflect the fact that SCCs are heterogenous and likely have unique molecular characteristics at different anatomical sites. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - March 17, 2015 Category: Pathology Authors: Katherine A. Cheng, Boaz Kurtis, Jian Zhuge, Irlna Tantchou, Dongming Cai, Rocco J. Lafaro, John T. Fallon, Minghao Zhong Tags: Original Contribution Source Type: research
