Clear cell papillary renal cell carcinoma, renal angiomyoadenomatous tumor and renal cell carcinoma with leiomyomatous stroma-relationship of three types of renal tumors
Discussion about possible relationship of both tumors were published since their description. As the main differencial diagnostic feature was considered presence/absence of fibroleiomyomatous stroma favoring diagnosis of RAT in stroma-rich tumors. However it was shown, that stroma is reactive, non-neoplastic by its nature and that all other histologic, immunohistochemical, and molecular-genetic features of both entities are identical. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - January 22, 2016 Category: Pathology Authors: Ondrej Hes, Eva Maria Compérat, Nathalie Rioux-Leclerc Source Type: research
Angiosarcoma Arising in Association with Vascular Dacron Grafts and Orthopedic Joint Prostheses: Clinicopathologic, Immunohistochemical and Molecular Study
Angiosarcoma may rarely arise in close proximity to inert foreign body material including vascular grafts and metal joint prostheses. 16 such cases have been reported since 1972 but mostly in the radiological or surgical literature without detailed histological or molecular analyses. We herein describe the clinicopathologic and molecular features of 2 new cases and reanalyzed 3 previously reported cases of angiosarcoma that developed in association with Dacron grafts for vascular repair (n=3) or related to orthopedic metal prostheses for joint replacement (n=2). (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - January 9, 2016 Category: Pathology Authors: Abbas Agaimy, Ofer Ben-Izhak, Thomas Lorey, Marcus Scharpf, Brian P. Rubin Source Type: research
p53 expression and relationship with MDM2 amplification in breast carcinomas
Carcinoma of the breast, like other malignancies, is a genetic disease with multiple genetic events leading to the malignant phenotype. p53 mutations are the most common genetic events in human cancer. Inactivation of p53 can be a result of mutation in gene sequence. One of the main structures that regulate p53 stabilization is MDM2. It suppresses p53 transcriptional activation by recognizing transactivation domain of p53. The loss of MDM2 function on p53 regulation results in deprivation of p53 tumor suppressor ability. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - January 8, 2016 Category: Pathology Authors: Nur Buyukpinarbasili, Zuhal Gucin, Yeliz Emine Ersoy, Ayca İlbak, Huseyin Kadioglu, Mahmut Muslumanoglu Source Type: research
p53 expressıon and relatıonshıp wıth MDM2 amplıfıcatıon ın breast carcınomas
Breast carcinoma is the most common malignant tumor and the leading cause of death from carcinoma in women, with more than 1.000.000 cases occuring worldwide annually. In Western developed countries like USA, the lifetime risk for breast cancer is one in eight women, approximately. (See Figs. 1 and 2.) (See Tables 1–11.) (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - January 8, 2016 Category: Pathology Authors: Nur Buyukpinarbasili, Zuhal Gucin, Yeliz Emine Ersoy, Ayca İlbak, Huseyin Kadioglu, Mahmut Muslumanoglu Source Type: research
Anatomic pathology in Cuba before 1959: a personal recollection
When we humans reach the twilight of our lives and become aware of our mortality, we start reminiscing and reconnecting with old friends and work colleagues of years past and recollecting our memories and experiences. I have been doing just that for several years with various degrees of success because the task is more difficult after one has experienced major changes, such as emigrating from your native country, as I did 33 years ago. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - December 16, 2015 Category: Pathology Authors: René J. Buesa Source Type: research
Recurrent TERT Promoter Mutations in Urothelial Carcinoma and Potential Clinical Applications
Increased telomerase activity is associated with almost all types of advanced human cancers with unknown molecular mechanism(s). Two recurrent point mutations in the promoter region of telomerase reverse transcriptase (TERT) - the key subunit of telomerase – have recently been identified in melanoma as well as a small sample of bladder cancer cell lines. However, the incidence and clinical-pathological significance of these mutations in urothelial carcinoma have not been well established yet. We collected 86 specimens of urothelial carcinoma including upper and lower urinary tract; high grade and low grade; invasive and ...
Source: Annals of Diagnostic Pathology - December 16, 2015 Category: Pathology Authors: Boaz Kurtis, Jian Zhuge, Caroline Ojaimi, Fei Ye, Dongming Cai, David Zhang, John T. Fallon, Minghao Zhong Tags: Original Contribution Source Type: research
Anatomic pathology in Cuba before 1958: a personal recollection
When we humans reach the twilight of our lives and become aware of our mortality, we start reminiscing and reconnecting with old friends and work colleagues of years past and recollecting our memories and experiences. I have been doing just that for several years with various degrees of success because the task is more difficult after one has experienced major changes, such as emigrating from your native country, as I did 33 years ago. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - December 16, 2015 Category: Pathology Authors: René J. Buesa Source Type: research
Lipophyllodes Of The Breast. A Reappraisal Of Fat-Rich Tumors Of The Breast Based On 22 Cases Integrated By Immunohistochemical Study, Molecular Pathology Insights And Clinical Follow Up
We have studied 22 cases of mammary lipophyllodes tumors (LPT), analyzing their clinicopathologic features along with available follow-up. All cases were tested for cytokeratins, S100 protein, MDM2, and in selected cases for ER, smooth muscle actin, bcl2, desmin and myogenin. Patients were females, 21–69 years of age, average 45 years; LPT size range was 1.6–30 cm, average 9.7 cm. Microscopically, LPT segregated as follows: atypical lipoma-like tumor/well differentiated liposarcoma (ALT/WDL), 8 cases; myxoid, 6; pleomorphic/poorly differentiated/round cell, 8, including a case of dedifferentiated liposarcoma. (Source: ...
Source: Annals of Diagnostic Pathology - December 9, 2015 Category: Pathology Authors: Carlos E. Bacchi, Sheila C. Wludarski, Janez Lamovec, David Ben Dor, Elisa Ober, Tiziana Salviato, Fabrizio Zanconati, Giovanna DeMaglio, Stefano Pizzolitto, Stefano Sioletic, Giovanni Falconieri Source Type: research
Outcomes of Gleason score 3 + 4 = 7 prostate cancer with minimal amounts (
This study was based on needle biopsy specimens that were categorized as GS 6 or GS 7 and were obtained from patients who underwent radical prostatectomy (RP) with available follow-up data. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - December 2, 2015 Category: Pathology Authors: Gozde Kır, Hatice Seneldir, Eyup Gumus Source Type: research
Outcomes of Gleason Score 3+4=7 Prostate Cancer with Minimal Amounts (
A modification to the International Society of Urological Pathology (ISUP) Gleason grading system was published in 2005. Since this modified system was introduced, certain patterns that were originally scored as Gleason pattern (GP) 3 have now been re-categorized as GP 4 [1]. For example, cribriform and other poorly formed glands are now graded as GP 4. Furthermore, following the modified Epstein criteria, all cribriform glands are now assessed as pattern 4 [2]. The ISUP consensus statement also recommends grading needle biopsy specimens with the most common GP as the primary pattern and the highest GP as the secondary pat...
Source: Annals of Diagnostic Pathology - December 2, 2015 Category: Pathology Authors: Gozde Kır, Hatice Seneldır, Eyup Gumus Source Type: research
Ossifying fibromyxoid tumor: morphology, genetics, and differential diagnosis
Ossifying fibromyxoid tumor (OFMT) is a soft tissue neoplasm of uncertain differentiation and intermediate (rarely metastasizing) biologic potential, with typical morphologic features, of an encapsulated, lobulated tumor comprising uniform polygonal cells within fibromyxoid stroma, which is surrounded by or contains metaplastic bone, classically as a peripheral rim of lamellar bone. Ossifying fibromyxoid tumor can arise at almost any site, although most frequently occurs within the extremities and trunk. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - December 1, 2015 Category: Pathology Authors: Nina Schneider, Cyril Fisher, Khin Thway Tags: Review Article Source Type: research
Ossifying fibromyxoid tumor: morphology, genetics and differential diagnosis
Ossifying fibromyxoid tumor (OFMT) is a soft tissue neoplasm of uncertain differentiation and intermediate (rarely metastasizing) biologic potential, with typical morphologic features, of an encapsulated, lobulated tumor comprising uniform polygonal cells within fibromyxoid stroma, which is surrounded by or contains metaplastic bone, classically as a peripheral rim of lamellar bone. OFMT can arise at almost any site, although most frequently occurs within the extremities and trunk. While most behave in a benign fashion, tumors can rarely show atypical or malignant features. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - December 1, 2015 Category: Pathology Authors: Nina Schneider, Cyril Fisher, Khin Thway Tags: Review Article Source Type: research
Editorial Board
(Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - November 28, 2015 Category: Pathology Source Type: research
Masthead
(Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - November 28, 2015 Category: Pathology Source Type: research
Table of Contents
(Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - November 28, 2015 Category: Pathology Source Type: research
