Adverse tissue reactions after total hip arthroplasty
Hip arthroplasty is commonly performed on patients with debilitating hip disease to relieve symptoms and improve quality of life. Generally, long-term success rates are excellent. However, a subset of patients requires revision due to prosthesis failure. A wide array of microscopic findings can be seen in surrounding tissues and many of the findings are etiologically nonspecific. The aim of this review is to discuss the etiologies and accompanying adverse tissue reactions seen with prosthesis failure, including the findings seen in aseptic lymphocyte –dominated vasculitis-associated lesion. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - August 17, 2016 Category: Pathology Authors: Ross A. Miller, Jae Y. Ro, Mary R. Schwartz Source Type: research
Aggressive B-cell lymphomas: frequency, immunophenotype, and genetics in a reference laboratory population
In this study, we evaluated 760 of cases of DLBCL and other aggressive B-cell lymphomas using a relatively uniform immunohistochemical panel and genetic methods. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - August 17, 2016 Category: Pathology Authors: Yalda B. Naeini, Annie Wu, Dennis P. O'Malley Source Type: research
Lobular Neoplasia Diagnosed on Breast Core Biopsy: Frequency of Carcinoma on Excision and Implications for Management
We report the findings at our institution, where virtually every core needle biopsy diagnosis of lobular neoplasia results in follow-up excision. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - August 17, 2016 Category: Pathology Authors: Benjamin C. Calhoun, Angela M.B. Collie, Abberly A. Lott-Limbach, Esther N. Udoji, Leah R. Sieck, Christine N. Booth, Erinn Downs-Kelly Source Type: research
Trends in Extramural Consultation: Comparison between Subspecialized and General Surgical Pathology Service Models
Academic and community hospital pathology groups are increasingly adopting subspecialized service models for surgical pathology (SP) practice. Reasons cited include improvements in sign-out efficiency, quality and accuracy, enhancement of clinician-pathologist communications, and augmentation of resident training quality. However, there is a paucity of published quantitative data regarding the outcomes of transitioning from general to subspecialized SP service coverage. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - August 17, 2016 Category: Pathology Authors: Yong-Jun Liu, Meghan Kessler, Dani S. Zander, Dipti M. Karamchandani Source Type: research
Adverse tissue reactions following total hip arthroplasty
Hip arthroplasty is commonly performed on patients with debilitating hip disease to relieve symptoms and improve quality of life. Generally, long term success rates are excellent. However, a subset of patients requires revision due to prosthesis failure. A wide array of microscopic findings can be seen in surrounding tissues and many of the findings are etiologically non-specific. The aim of this review is to discuss the etiologies and accompanying adverse tissue reactions seen with prosthesis failure, including the findings seen in aseptic lymphocyte –dominated vascular lesion (ALVAL). (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - August 17, 2016 Category: Pathology Authors: Ross A. Miller, Jae Y. Ro, Mary R. Schwartz Source Type: research
Aggressive B cell lymphomas: frequency, immunophenotype and genetics in a reference laboratory population
In this study we evaluated 760 of cases of DLBCL and other aggressive B cell lymphomas using a relatively uniform immunohistochemical panel and genetic methods. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - August 17, 2016 Category: Pathology Authors: Yalda B. Naeini, Annie Wu, Dennis P. O'Malley Source Type: research
Key Gaps in Pathologic Reporting for Appendiceal Mucinous Neoplasms: Time for Universal Synoptic Reporting?
The prognosis of appendiceal mucinous neoplasms (AMN) is directly related to their histopathology. Existing classification schemes encompass tumors with widely divergent clinical behaviors within a single diagnosis, making it difficult for clinicians to interpret pathology reports to counsel patients on optimal management. We sought to examine pathology reports generated for AMN for inclusion of essential histologic features. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - August 17, 2016 Category: Pathology Authors: Eisar Al-Sukhni, Charles LeVea, Joseph Skitzki, John Kane, Valerie Francescutti Source Type: research
Intralymphatic Nevus Cells in Benign Nevi
The histogenesis of nevus cell aggregates in lymph nodes lesion is controversial and various hypotheses have been used to explain their origin. One of them is the transport of cells from cutaneous nevi or lesions to lymph nodes, called mechanical transport theory. We investigated in our cases of benign nevi to obtain evidence to substantiate this theory. 369 benign cutaneous nevi were prospectively evaluated in excisional biopsy samples. Immunohistochemical stainings for CD31 and podoplanin (D2 –40) were performed in the cases with intralymphatic nevus cell aggregate (ILNA), suspected for ILNA and/or intralymphatic nevus...
Source: Annals of Diagnostic Pathology - August 17, 2016 Category: Pathology Authors: Cem Leblebici, Canan Kelten, Mehmet Salih Gurel, Ezgi Hac ıhasasanoglu Source Type: research
Proliferation centers in bone marrows involved by chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL): a clinicopathologic analysis
Proliferation centers (PCs) are a characteristic finding in CLL/SLL lymph nodes, and their presence and extent in this site are not currently felt to be related to clinical course. In contrast, detailed clinicopathologic analyses of bone marrow (BM) PCs have not been previously reported. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - August 17, 2016 Category: Pathology Authors: Jason C. Chang, Alexandra M. Harrington, Horatiu Olteanu, Peter VanTuinen, Steven H. Kroft Source Type: research
Diagnostic utility of epithelial and melanocitic markers with double sequential immunohistochemical staining in differentiating melanoma in situ from invasive melanoma
Identification of melanoma in situ and its distinction from invasive melanoma is important due to its significant impact on morbidity and mortality. However, This interpretation can cause pitfalls in the diagnosis even with the use of immunohistochemistry. The aim of this study is to evaluate the diagnostic utility of epithelial makers (AE1/AE3, CK5/6 and p63) combined with melanocytic markers (HMB-45 S-100 or Melan A) using dual-color immunohistochemical staining, performed on a single slide by sequentially applying the antibodies. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - August 17, 2016 Category: Pathology Authors: Rafael Parra-Medina, Samuel David Morales Source Type: research
Lymphoepithelioma-like carcinoma of breast —evaluation for Epstein-Barr virus–encoded RNA, human papillomavirus, and markers of basal cell differentiation
This is a largest series of 5 cases of lymphoepithelioma-like carcinoma (LEC) of the breast attempting to look at the expression of basal cytokeratins (CKs), human papillomavirus, and Epstein-Barr virus –encoded RNAs in these tumors. Five cases were selected after stringent evaluation of all breast carcinomas showing dense lymphoid infiltration. Histologically, all these tumors showed the typical histology except 1 tumor that showed an unusual granulomatous response. All tumors were negative for estrogen and progesterone receptors and HER2 (triple negative). (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - August 15, 2016 Category: Pathology Authors: Tanuja Shet, Trupti Pai, Omshree Shetty, Sangeeta Desai Source Type: research
Differential expression of epithelial cell adhesion molecule in salivary gland neoplasms
Epithelial cell adhesion molecule (EpCAM) is the epithelial-specific molecule expressed on various epithelial cell types. The function of EpCAM involves cellular adhesion, proliferation, and signaling in both normal tissues and cancers. The purposes of this study were to investigate the EpCAM expression in salivary gland neoplasms and examine its relationship with pathologic characteristics. Forty-two cases of salivary gland neoplasms, including 20 mucoepidermoid carcinomas (MECs), 11 adenoid cystic carcinomas (ACCs), 9 pleomorphic adenomas (PAs), and 2 polymorphous low-grade adenocarcinomas (PLGAs) were enrolled. (Source:...
Source: Annals of Diagnostic Pathology - August 15, 2016 Category: Pathology Authors: Ekarat Phattarataratip, Marisa Masorn, Werapong Jarupoonphol, Sirinpaporn Supatthanayut, Pichanee Saeoweiang Source Type: research
Re: Mammary analog secretory carcinoma of salivary glands: a clinicopathologic study of 11 cases
I have read, with much interest, the study of Din et al [1] on 11 cases of mammary analog secretory carcinoma (MASC) of salivary glands and would like to congratulate them on their publication. However, the authors confirmed thrice that they have reported the youngest patient ages with MASC (9 and 9.5 years old), whereas Keisling et al [2] have reported an MASC case of minor salivary glands of the right cheek associated with t(12;15)(p13;q25) ETV6-NTRK3 gene fusion in a 5-year-old female, earlier in 2014. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - August 15, 2016 Category: Pathology Authors: Bacem A.E.O Khalele Source Type: research
Lymphoepithelioma like carcinoma of breast- Evaluation for Epstein Barr Virus encoded RNA (EBER), Human papilloma virus (HPV) and markers of basal cell differentiation
This is a largest series of five cases of lymphoepithelioma like carcinoma (LEC) of the breast attempting to look at the expression of basal cytokeratins, Human Papilloma Virus (HPV) and Epstein Barr virus encoded RNA's (EBER) in these tumors. Five cases were selected after stringent evaluation of all breast carcinoma showing dense lymphoid infiltration. Histologically all these tumors showed the typical histology except one tumor that showed an unusual granulomatous response. All tumors were negative for estrogen and progesterone receptor and HER2 (Triple negative). (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - August 15, 2016 Category: Pathology Authors: Tanuja Shet, Trupti Pai, Omshree Shetty, Sangeeta Desai Source Type: research
Immunoexpression of p53 in cutaneous and subcutaneous leiomyosarcomas
In this report, we study the immunoexpression of p53 in 19 malignant smooth muscle tumors of the skin (15 cutaneous leiomyosarcomas, two subcutaneous leiomyosarcomas and two cutaneous metastases of leiomyosarcoma), as well as in one leiomyoma with cellular atypia, therefore complementing a previous study on p53 immunoexpression in leiomyomas of the skin. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - August 15, 2016 Category: Pathology Authors: Angel Fernandez-Flores, Carlos Monteagudo Source Type: research
