Surgical follow up results for apocrine adenosis and atypical apocrine adenosis diagnosed on breast core biopsy
This study aimed to determine the frequency of carcinoma on follow up excision (FUE) in patients with a diagnosis of AA or AAA on core biopsy. Forty-one breast core biopsies of AA (n=29) and AAA (n=12) were identified during a study period of 12 years. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - July 10, 2016 Category: Pathology Authors: Yanjun Hou, Shweta Chaudhary, Faye F. Gao, Zaibo Li Source Type: research
The role of mast cells in histologically “normal” appendices following emergency appendectomy in pediatric patients
Fifteen percent to 25% of appendices resected for a preoperative diagnosis of acute appendicitis have no neutrophilic infiltration, thus histologically “normal.” The discrepancy between clinical presentation and the lack of definite morphologic changes is confounding. It has been indicated that mast cells may play a role in the pathogenesis of the appendicitis-like pain in patients with histologically negative appendices (HNAs). To investigate whether mast cell density (MCD) is increased in pediatric HNAs, we retrieved 50 appendectomy cases (30 HNA and 20 control, ages 2 days-18 years) in our institute in the last 10 y...
Source: Annals of Diagnostic Pathology - June 22, 2016 Category: Pathology Authors: Zhongbo Yang, Magda Esebua, Lester Layfield Source Type: research
The Role of Mast Cells in Histologically “Normal” Appendices Following Emergency Appendectomy in Pediatric Patients
15–25% of appendices resected for a preoperative diagnosis of acute appendicitis have no neutrophilic infiltration, thus histologically “normal”. The discrepancy between clinical presentation and the lack of definite morphologic changes is confounding. It has been indicated that mast cells may play a role in the pathogenesis of the appendicitis-like pain in patients with histologically negative appendices (HNA). To investigate whether mast cells density (MCD) is increased in pediatric HNA appendices, we retrieved 50 appendectomy cases (30 HNA and 20 control, ages 2 days – 18 years) in our institute in the last 10 y...
Source: Annals of Diagnostic Pathology - June 22, 2016 Category: Pathology Authors: Zhongbo Yang, Magda Esebua, Lester Layfield Source Type: research
Comparative study of TERT gene mutation analysis on voided liquid-based urine cytology and paraffin-embedded tumorous tissue
Noninvasive reliable urine-based screening method for detection of urothelial carcinoma (UC) is still highly elusive. Recently, studies have shown the presence of telomerase reverse transcriptase (TERT) gene mutation in a high number of UCs. This finding can be used as a marker in screening voided urine samples. The aim of this study was to assess sensitivity of TERT mutation in detecting UC between liquid-based cytology (LBC) voided urine and formalin-fixed, paraffin-embedded neoplastic tissue (FFPE). (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - June 16, 2016 Category: Pathology Authors: Kristyna Pivovarcikova, Tomas Pitra, Tomas Vanecek, Reza Alaghehbandan, Barbora Gomolcakova, Ondrej Ondic, Kvetoslava Peckova, Pavla Rotterova, Milan Hora, Martin Dusek, Michal Michal, Ondrej Hes Source Type: research
Comparative study of TERT gene mutation analysis on voided liquid based urine cytology and paraffin embedded tumorous tissue
Non-invasive reliable urine-based screening method for detection of urothelial carcinoma (UC) is still highly elusive. Recently studies have shown presence of TERT gene mutation in a high number of UCs. This finding can be used as a marker in screening voided urine samples. The aim of this study was to assess sensitivity of TERT mutation in detecting UC between liquid based cytology (LBC) voided urine and formalin fixed paraffin embedded neoplastic tissue (FFPE). Voided urine of 29 patients was collected prior to surgery via LBC. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - June 16, 2016 Category: Pathology Authors: Kristyna Pivovarcikova, Tomas Pitra, Tomas Vanecek, Reza Alaghehbandan, Barbora Gomolcakova, Ondrej Ondic, Kvetoslava Peckova, Pavla Rotterova, Milan Hora, Martin Dusek, Michal Michal, Ondrej Hes Source Type: research
Peripheral Nerve Sheath Tumors Arising in Salivary Glands: A Clinicopathologic Study
This study is a retrospective, clinicopathologic review of 9 cases of PNST (5 neurofibromas, 3 schwannomas and 1 malignant peripheral nerve sheath tumor (MPNST)) arising from the salivary glands, encountered between 1990–2015. All patients with neurofibromas were male (ages 1–62 years) and had a single parotid lesion of which two were diffuse, two plexiform and one mixed diffuse/plexiform. Four had a history of neurofibromatosis I. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - June 4, 2016 Category: Pathology Authors: Sahejmeet S. Guraya, Richard A. Prayson Source Type: research
A Single Center's Approach to Discriminating Donor Versus Host Origin of Renal Neoplasia in the Allograft Kidney
We report our experience utilizing Penta-C (PC) and Penta-D (PD) short tandem repeat (STR) microsatellite analysis to discriminate between host and donor origin of RCC identified in renal allografts. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - May 26, 2016 Category: Pathology Authors: Adam J. Robin, Eric P. Cohen, Tepsiri Chongkrairatanakul, Ehad Saad, A. Craig Mackinnon Source Type: research
Follicular dendritic cell sarcoma: clinicopathologic study of 15 cases with emphasis on novel expression of MDM2, somatostatin receptor 2A, and PD-L1
In this study, we reviewed 15 FDCSs retrieved from our consultation files and stained them for newly reported or novel markers (PD-L1, Rb1, MDM2, and somatostatin receptor 2A [SSTR2A]) in addition to conventional FDC markers. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - May 17, 2016 Category: Pathology Authors: Abbas Agaimy, Michael Michal, Ladislav Hadravsky, Michal Michal Source Type: research
Utility of a Standardized Protocol for Submitting Clinically Suspected Endometrial Polyps to the Pathology Laboratory
The purpose of the study is to assess whether a protocol for submitting clinically suspected endometrial polyps will improve the detection rate of polyps and evaluation of the background endometrium. A retrospective review from 1999–2015 was performed. Cases were divided into: 1) polyps and curetting placed in 2 containers (separate, n=61) and 2) polyps and curettings placed in one container (combined, n=80). Polyps were identified in 100% of cases in the separate compared to 95% in the combined group (P=.62). (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - May 17, 2016 Category: Pathology Authors: Nida S. Safdar, Giovanna Giannico, Mohamed Mokhtar Desouki Source Type: research
Follicular Dendritic Cell Sarcoma: Clinicopathological Study of 15 Cases with Emphasis on Novel Expression of MDM2, Somatostatin Receptor 2A and PD-L1
In this study we reviewed 15 FDCSs retrieved from our consultation files and stained them for newly reported or novel markers (PD-L1, Rb1, MDM2 and somatostatin receptor 2A/SSTR2A) in addition to conventional FDC markers. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - May 17, 2016 Category: Pathology Authors: Abbas Agaimy, Michael Michal, Ladislav Hadravsky, Michal Michal Source Type: research
Is The Routine Microscopic Examination of Proximal and Distal Resection Margins in Colorectal Cancer Surgery Justified?
Colorectal cancer (CRC) is the second most common cause of cancer death in the United States with over 52,000 Americans expected to die of large bowel cancer this year [1]. Complete surgical excision of all detectable tumor is verified by the pathologist's examination and documentation of the tumor-free status of all surgical margins [2]. The true proximal and distal margins in CRC surgery are usually the stapled “donuts” that result from the anastomosis of the intestine at either side of the resected segment and are routinely submitted in a separate container. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - May 6, 2016 Category: Pathology Authors: Diana M. Morlote, John B. Alexis Source Type: research
Solid papillary renal cell carcinoma: clinicopathologic, morphologic, and immunohistochemical analysis of 10 cases and review of the literature
Solid papillary renal cell carcinoma is rarely reported in the literature, and its tumor characteristics are not entirely compatible with the concept of 2 histological subtypes of papillary renal cell carcinoma (PRCC). Tumor is composed mostly of small compressed tubules and short abortive papillae giving solid appearance of monomorphic epithelial cells with scanty cytoplasm and small nuclei, sometimes mimicking spindle cells, without or with sparse true papillae. It shows immunohistochemical (+CK7, +EMA, +AMACR) and genetic hallmarks (polysomy/trisomy 7/17, loss of Y) of conventional PRCC. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - April 25, 2016 Category: Pathology Authors: Monika Ulamec, Faruk Skenderi, Kiril Trpkov, Bozo Kruslin, Semir Vranic, Stela Bulimbasic, Sandra Trivunic, Delia Perez Montiel, Kvetoslava Peckova, Kristyna Pivovarcikova, Ondrej Ondic, Ondrej Daum, Pavla Rotterova, Martin Dusek, Milan Hora, Michal Micha Source Type: research
Solid papillary renal cell carcinoma: Clinicopathologic, morphologic and immunohistochemical analysis of 10 cases and review of the literature
Solid papillary renal cell carcinoma is rarely reported in the literature and its tumor characteristics are not entirely compatible with the concept of two histological subtypes of papillary renal cell carcinoma (PRCC). Tumor is composed mostly of small compressed tubules and short abortive papillae giving solid appearance of monomorphic epithelial cells with scanty cytoplasm and small nuclei, sometimes mimicking spindle cells, without or with sparse true papillae. It shows immunohistochemical (+CK7, +EMA, +AMACAR) and genetic hallmarks (polysomy/trisomy 7/17, loss of Y) of conventional PRCC. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - April 25, 2016 Category: Pathology Authors: Monika Ulamec, Faruk Skenderi, Kiril Trpkov, Bozo Kruslin, Semir Vranic, Stela Bulimbasic, Sandra Trivunic, Delia Perez Montiel, Kvetoslava Peckova, Kristyna Pivovarcikova, Ondrej Ondic, Ondrej Daum, Pavla Rotterova, Martin Dusek, Milan Hora, Michal Micha Source Type: research
