Solid papillary renal cell carcinoma: Clinicopathologic, morphologic and immunohistochemical analysis of 10 cases and review of the literature

Solid papillary renal cell carcinoma is rarely reported in the literature and its tumor characteristics are not entirely compatible with the concept of two histological subtypes of papillary renal cell carcinoma (PRCC). Tumor is composed mostly of small compressed tubules and short abortive papillae giving solid appearance of monomorphic epithelial cells with scanty cytoplasm and small nuclei, sometimes mimicking spindle cells, without or with sparse true papillae. It shows immunohistochemical (+CK7, +EMA, +AMACAR) and genetic hallmarks (polysomy/trisomy 7/17, loss of Y) of conventional PRCC.

Source: Annals of Diagnostic Pathology - April 25, 2016 Category: Pathology Authors: Monika Ulamec, Faruk Skenderi, Kiril Trpkov, Bozo Kruslin, Semir Vranic, Stela Bulimbasic, Sandra Trivunic, Delia Perez Montiel, Kvetoslava Peckova, Kristyna Pivovarcikova, Ondrej Ondic, Ondrej Daum, Pavla Rotterova, Martin Dusek, Milan Hora, Michal Micha Source Type: research