EWSR1 rearrangement is present in a subset of myoepithelial tumors of salivary glands with variable morphology that cannot distinguish myoepithelial tumors from its malignancy
We examined 37 cases of MTs, including 24 BMTs, 13 MMTs, by histological, immunohistochemical, and molecular analysis. All of 37 cases were immunoreactive for CKpan, and at least one myoepithelial marker. 26 of 37 cases of MTs were available to be analyzed for EWSR1 rearrangement, with the result that EWSR1 gene break was detected in 4 cases of 15 BMTs, and 4 cases of 11 MMTs. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - February 12, 2017 Category: Pathology Authors: Hao Ni, Pei-yu Zhao, Xiao-tong Wang, Qiu-yuan Xia, Xuan Wang, Nan Wu, Shan-shan Shi, Rui Li, Wan-rui Yang, Heng-hui Ma, Xiao-jun Zhou, Qiu Rao Source Type: research
Diagnostic pathology of Alzheimer's disease from routine microscopy to immunohistochemistry and experimental correlations
The absence of any histologic correlate for Alzheimer's disease despite its commonness and severe clinical sequelae may offers clues to its etiology. Recent evidence strongly suggests that the central event of this disease is the hyperphosphorylation of neuronal tau protein and not the beta amyloid precipitates. In each case, essential and soluble neuronal proteins derivatives form insoluble aggregates that can readily be detected by immunohistochemistry using antibodies specific for the misfolded proteins. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - February 11, 2017 Category: Pathology Authors: Gerard Nuovo, Bernard Paniccia, Louisa Mezache, Maria Qui ñónez, James Williams, Paige Vandiver, Paolo Fadda, Vicky Amann Source Type: research
Upregulation of inhibitory signaling receptor programmed death marker-1 (PD-1) in disease evolution from cutaneous lymphoid dyscrasias to mycosis fungoides and Sezary's syndrome
Negative immunoregulatory checkpoints impede effective immune responses to tumor and reduce the action of anticancer agents. One such example is programmed death marker-1 (PD-1), an inhibitory signaling receptor expressed on activated and regulatory T-cells. PD-1 expression was reported in a few reports, but the expression profile of PD-1 and mycosis fungoides (MF) remains largely to be characterized. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - February 9, 2017 Category: Pathology Authors: Giang Huong Nguyen, Luke C. Olson, Cynthia M. Magro Source Type: research
Cholesteryl Ester Storage Disease: An underdiagnosed cause of cirrhosis in adults
Cholesteryl Ester Storage Disease (CESD), is a rare multisystem autosomal recessive disorder and belongs to the broad family of lysosomal storage disorders. It can present anytime from infancy and childhood to even adulthood. The clinical manifestations are generally severe in infants and with milder forms in adults. One of the prominent sites of involvement is liver. Due to low awareness of this condition among physicians including surgical pathologists, majority of the liver biopsies, especially from the adults are often misdiagnosed as nonalcoholic fatty liver disease/nonalcoholic steatohepatitis or cryptogenic cirrhosi...
Source: Annals of Diagnostic Pathology - February 9, 2017 Category: Pathology Authors: Mamata Pant, Kiyoko Oshima Source Type: research
Molecular alterations in lesions of anogenital mammary-like glands and their mammary counterparts including hidradenoma papilliferum, intraductal papilloma, fibroadenoma and phyllodes tumor
Lesions affecting anogenital mammary –like glands (AGMLG) are histopathologically very similar to those seen in the breast but whether this morphological similarity is also reflected at the genetic level is unknown. To compare the underlying molecular mechanisms in lesions of AGMLG and their mammary counterparts, we analyzed the muta tional profile of 16 anogenital neoplasms including 5 hidradenomas papilliferum (HP), 1 lesion with features of HP and fibroadenoma (FA), 7 FA, 3 phyllodes tumors (PhT)) and 18 analogous breast lesions (6 intraductal papillomas (IDP), 9 FA, and 3 PhT) by high-coverage next generation sequenc...
Source: Annals of Diagnostic Pathology - February 9, 2017 Category: Pathology Authors: Anastasia M. Konstantinova, Tomas Vanecek, Petr Martinek, Liubov Kyrpychova, Dominic V. Spagnolo, Colin J.R. Stewart, Francesca Portelli, Michal Michal, Dmitry V. Kazakov Source Type: research
Effectiveness and safety of two 18-gauge needle types on native and allograft renal biopsies
Percutaneous biopsy is a key diagnostic tool for both native and allograft kidney diseases. Adequacy criteria vary, but at a minimum, a biopsy should allow the pathologist to reach a diagnosis and provide prognostic information such as the degree of interstitial fibrosis and tubular atrophy (IF/TA) and percentage of glomerulosclerosis. Whereas most studies use glomerular counts as a surrogate for biopsy adequacy, the amount and preservation of tubulointerstitium is equally important, considering IF/TA is a major prognostic parameter for most medical renal diseases. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - February 3, 2017 Category: Pathology Authors: Clarissa A. Cassol, Juarez R. Braga, Samer Dabbo, K. Khalili, C. Avila-Casado Source Type: research
Prognostic impact of EGFR and cytokeratin 5/6 immunohistochemical expression in triple-negative breast cancer
Triple-negative breast cancers (TNBC) constitute about 10% –17% of all breast carcinomas worldwide and it is defined by the lack of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor-2 (Her2neu) expressions. It is common among young African, African American, and Latino women [1]. Triple-negative breast cancers usually e xpress a unique molecular profile, unfavorable behavior, and specific patterns of metastasis, including mostly the liver, central nervous system, and lungs [2]. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - February 2, 2017 Category: Pathology Authors: Aziza E. Abdelrahman, Hayam E. Rashed, Mohamed Abdelgawad, Mohamed I. Abdelhamid Source Type: research
Whorling cellular perineurioma: A previously undescribed variant closely mimicking monophasic fibrous synovial sarcoma
The authors present a distinctive perineurioma (PN) variant which morphologically strongly resembles monophasic fibrous synovial sarcoma (MSS). The patients were 3 males and 1 female. The age ranged from 15 to 61years (mean: 44years). Locations included the sole, lower jaw, palm and foot. The tumor size ranged from 1.3cm to 2.5cm in the largest dimension (mean 1.8cm). Morphologically, all tumors had an identical, monotonous appearance. The perineurial cells were closely packed and created a confluent cellular whorls and/or sheets in a scarce stroma, with only focally discernible long, slender cytoplasmic processes typical ...
Source: Annals of Diagnostic Pathology - February 1, 2017 Category: Pathology Authors: Michael Michal, Dmitry V. Kazakov, Abbas Agaimy, Marta Hosova, Kvetoslava Michalova, Petr Grossmann, Petr Steiner, Faruk Skenderi, Semir Vranic, Michal Michal Source Type: research
Contribution of MAML1 in esophageal squamous cell carcinoma tumorigenesis
In this study, we aimed to examine MAML1 protein expression in esophageal squamous cell carcinoma (ESCC) and reveal its association with clinicopathological variables of the patients. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - January 31, 2017 Category: Pathology Authors: Mahnaz Hashemi Bidokhti, Mohammad Mahdi Forghanifard, Noorieh Sharifi, Soodabeh Abbasi Sani, Mohammad Reza Abbaszadegan Source Type: research
Retroperitoneal lymphangioleiomyoma with lymph node involvement: A pathologic-radiologic correlation of a rare form of myomelanocytic tumor
Lymphangioleiomyomatosis (LAM) is a rare and slowly progressive disorder that usually arises in the lung, affects exclusively women in their childbearing years, and typically presents with progressive dyspnea on exertion and pneumothorax. Infrequently, extra-pulmonary LAM can occur in the retroperitoneum, uterine wall, mediastinum and intraperitoneal lymph nodes. Histologically, LAM is characterized by a proliferation of perivascular epithelioid cells (PEC) that express markers for both melanocytes and smooth muscle cells. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - January 31, 2017 Category: Pathology Authors: Amrou Abdelkader, Cesar A. Lam, Kaushik S. Shahir, Kathleen Christians, Saul M. Suster Source Type: research
Methylation analysis of SHOX2 and RASSF1A in bronchoalveolar lavage fluid for early lung cancer diagnosis
Lung cancer is the most common cancer worldwide [1]. In China, Lung cancer is the leading cause of cancer death [2]. Studies have shown that early diagnosis can improve 5-year survival rate remarkably, but there are few effective and cheap methods available so far for early detection and screening of lung cancer, because of the heterogeneity of clinical manifestations and pathologic features [3,4]. At present, for patients with suspected lung cancer, the fiberoptic bronchoscopy examination is often performed earlier, and the cytology specimens in bronchoalveolar lavage fluid (BALF) can be obtained at the first time. (Sourc...
Source: Annals of Diagnostic Pathology - January 20, 2017 Category: Pathology Authors: Minpu Ren, Chunhua Wang, Danli Sheng, Yaoyao Shi, Mei Jin, Songxiao Xu Source Type: research
The role and prognostic value of inducible nitric oxide synthase (iNOS) and interleukin-33 (IL-33) in serous and mucinous epithelial ovarian tumours
Understanding different mechanisms contributing to the aggressive behaviour of epithelial ovarian cancer (EOC) is a large challenge. Interaction between inflammation, immunity and carcinogenesis occurs in different cancers; however, the potential roles of different molecules involved in these processes in relation to ovarian carcinogenesis were not fully investigated. Inducible nitric oxide synthase (iNOS) and interleukin-33 (IL-33) are implicated in carcinogenesis. iNOS is an NOS isoform that generates nitric oxide, which plays important roles in various stages of carcinogenesis. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - January 20, 2017 Category: Pathology Authors: Eman M. Saied, Nour M. El-Etreby Source Type: research
Postradiation-associated sclerosing mediastinitis diagnosed in fine needle aspiration specimen: A cytological –pathological correlation
Sclerosing mediastinitis (SM) is an aggressive fibroproliferative process in the mediastinum that may lead to encasement of mediastinal structures within a dense fibrotic mass. This disease may cause significant clinical complications, morbidity, and even mortality. The etiology and pathogenesis of SM is unclear and in more than one third of cases remains idiopathic. Among the known causes of SM, granulomatous infection is the commonest. Association of SM with radiation therapy has been rarely reported. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - January 18, 2017 Category: Pathology Authors: Tamar Giorgadze, June H. Koizumi, Shira Ronen, Michael Chaump, Cynthia M. Magro Source Type: research
Seromucinous ovarian tumor A comparison with the rest of ovarian epithelial tumors
Seromucinous ovarian tumors are rare and not adequately described in the literature and this is especially true for seromucinous carcinomas. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - January 6, 2017 Category: Pathology Authors: Georgia Karpathiou, Celine Chauleur, Thomas Corsini, Melany Venet, Cyril Habougit, Freschia Honeyman, Fabien Forest, Michel Peoc'h Source Type: research
Immunohistochemistry in the workup of prostate biopsies: Frequency, variation and appropriateness of use among pathologists practicing at an academic center
We studied the frequency, inter-pathologist variation, appropriateness and utility of immunohistochemistry (IHC) performed on prostate biopsies (PB) to determine the significance of foci of suspicious glands or atypical small acinar proliferations (ASAP). (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - January 5, 2017 Category: Pathology Authors: Sameer Al Diffalha, Mohanad Shaar, G üliz A. Barkan, Eva M. Wojcik, Maria M. Picken, Stefan E. Pambuccian Source Type: research
