Prognostic impact of EGFR and cytokeratin 5/6 immunohistochemical expression in triple-negative breast cancer

Triple-negative breast cancers (TNBC) constitute about 10% –17% of all breast carcinomas worldwide and it is defined by the lack of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor-2 (Her2neu) expressions. It is common among young African, African American, and Latino women [1]. Triple-negative breast cancers usually e xpress a unique molecular profile, unfavorable behavior, and specific patterns of metastasis, including mostly the liver, central nervous system, and lungs [2].

Source: Annals of Diagnostic Pathology - February 2, 2017 Category: Pathology Authors: Aziza E. Abdelrahman, Hayam E. Rashed, Mohamed Abdelgawad, Mohamed I. Abdelhamid Source Type: research