Instructions to Authors
(Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - November 28, 2015 Category: Pathology Source Type: research
Cytokeratin 17 immunoexpression in actinic keratosis (bowenoid and nonbowenoid) and in Bowen disease
Cytokeratin (CK) 17 immunoexpression has been investigated in nonmelanoma skin cancer as well as in many preinvasive epithelial malignancies. However, there is not any previous study of CK17 immunoexpression in actinic keratosis (AK) or Bowen disease in nonimmunocompromised patients. We evaluated CK17 immunoexpression in 20 cases of AK (10 nonbowenoid and 10 bowenoid) as well as in 10 cases of Bowen disease. We identified expression of CK17 in the superficial layers above the atypical foci. In some cases, there were foci of expression by the full thickness of the epidermis, which was the predominant pattern in very few cas...
Source: Annals of Diagnostic Pathology - November 10, 2015 Category: Pathology Authors: Angel Fernandez-Flores Tags: Original Contribution Source Type: research
CK 17 immunoexpression in actinic keratosis (bowenoid and non-bowenoid) and in Bowen disease
Cytokeratin (CK) 17 immunoexpression has been investigated in non-melanoma skin cancer as well as in many pre-invasive epithelial malignancies. However, there is not any previous study of CK 17 immunoexpression in actinic keratosis (AK) or Bowen disease in non-immunocompromised patients. We evaluate CK17 immunoexpression in 20 cases of AK (10 non-bowenoid and 10 bowenoid) as well as in 10 cases of Bowen disease. We identified expression of CK17 in the superficial layers above the atypical foci. In some cases there were foci of expression by the full thickness of the epidermis, which was the predominant pattern in very few ...
Source: Annals of Diagnostic Pathology - November 10, 2015 Category: Pathology Authors: Angel Fernandez-Flores Tags: Original Contributions Source Type: research
Aberrant keratin 7 and 20 expression in triple-negative carcinoma of the breast
Early studies characterizing the keratin (K) profile of various epithelial tissues indicated that breast carcinoma is K7-positive and K20-negative, but not all breast carcinomas show this profile. Triple-negative carcinoma (TNC) has been characterized by negativity for estrogen receptor (ER), progesterone receptor (PgR), and Her2/neu protein. TNC is more likely to metastasize to the viscera and present as a metastatic poorly different carcinoma. In our study, based on immunohistochemical staining of ER, PgR and Her2/neu, 75 of the 290 invasive breast carcinoma patients were judged to TNC. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - October 31, 2015 Category: Pathology Authors: Hajime Kuroda, Yasuo Imai, Hidetsugu Yamagishi, Yoshihiko Ueda, Kazuko Kuroso, Yoko Oishi, Hitoshi Ohashi, Akinori Yamashita, Yoshiko Yashiro, Hisaki Fukushima Tags: Original Contribution Source Type: research
Low-grade metastases in high-grade clear cell renal cell carcinomas
Clear cell renal cell carcinoma (CCRCC) frequently develops distant metastases. However, high-grade primary CCRCC rarely leads to low-grade metastases. Cellular changes occurring during neoplastic progression known as epithelial-to-mesenchymal and mesenchymal-to-epithelial transitions explain this apparent contradiction. Four high-grade CCRCCs, which lead to low-grade metastases, are analyzed in this study, with the focus on epithelial-to-mesenchymal and mesenchymal-to-epithelial processes. Clinicopathologic data have been collected retrospectively and immunohistochemistry has been performed with E-cadherin, N-cadherin, vi...
Source: Annals of Diagnostic Pathology - October 29, 2015 Category: Pathology Authors: José I. López, Lorena Mosteiro, Rosa Guarch, Gorka Larrinaga, Rafael Pulido, Javier C. Angulo Tags: Original Contribution Source Type: research
Low-grade metastases in high-grade clear cell renal cell carcinomas A clinico-pathological study of 4 cases with an insight into the role of mesenchymal-to-epithelial transition process
Clear cell renal cell carcinoma (CCRCC) frequently develops distant metastases. However, high-grade primary CCRCC rarely leads to low-grade metastases. Cellular changes occurring during neoplastic progression known as epithelial-to-mesenchymal (EMT) and mesenchymal-to-epithelial (MET) transitions explain this apparent contradiction. Four high-grade CCRCC which lead to low-grade metastases is analyzed in this study with the focus on EMT and MET processes. Clinico-pathological data have been collected retrospectively and immunohistochemistry performed with E-Cadherin, N-Cadherin, Vimentin and WT-1. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - October 29, 2015 Category: Pathology Authors: José I. López, Lorena Mosteiro, Rosa Guarch, Gorka Larrinaga, Rafael Pulido, Javier C. Angulo Tags: Original Contribution Source Type: research
The effect of neoadjuvant therapy on the size, number, and distribution of mesorectal lymph nodes
The current therapeutic approach to patients with locally advanced rectal cancer is neoadjuvant radiotherapy or chemoradiotherapy followed by total mesorectal excision. We aimed to investigate the number, size, and distribution of metastatic and nonmetastatic lymph nodes within the mesorectum; whether neoadjuvant therapy has any impact on the number and size of the lymph nodes; and the impact of metastatic lymph node localization on overall and disease-free survival. Specimens from 50 consecutive patients with stage II/III rectal cancer receiving either neoadjuvant radiotherapy or chemoradiotherapy were investigated. (Sour...
Source: Annals of Diagnostic Pathology - October 28, 2015 Category: Pathology Authors: Gülçin Yegen, Metin Keskin, Melek Büyük, Enver Kunduz, Emre Balık, Esra Kaytan Sağlam, Yersu Kapran, Oktar Asoğlu, Mine Güllüoğlu Tags: Original Contribution Source Type: research
Pleomorphic hyalinizing angiectatic tumor revisited: all tumors manifest typical morphologic features of myxoinflammatory fibroblastic sarcoma, further suggesting 2 morphologic variants of a single entity
We describe 9 cases of pleomorphic hyalinizing angiectatic tumor (PHAT). Recently described TGFBR3 and MGEA5 gene rearrangements in these tumors have confirmed the long-hypothesized link between PHAT and another soft tissue entity, the myxoinflammatory fibroblastic sarcoma (MIFS). Myxoinflammatory fibroblastic sarcoma and PHAT share the same translocation and in addition have a very similar clinical presentation. However, to our best knowledge, no study has ever addressed the striking morphologic similarities between MIFS and PHAT. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - October 28, 2015 Category: Pathology Authors: Michael Michal, Dmitry V. Kazakov, Ladislav Hadravský, Abbas Agaimy, Marián Švajdler, Naoto Kuroda, Michal Michal Tags: Original Contribution Source Type: research
Schwannomas with pseudoglandular elements: Clinicopathologic study of 61 cases
Schwannomas are benign neoplasms of peripheral nerve sheath. A number of morphologic variants of Schwannoma have been described. The pseudoglandular variant is very rare. We retrieved and reviewed H&E slides of all cases of Schwannoma reported between 2007 and 2014 to look for pseudoglandular elements. Pseudoglandular cystic spaces were seen in 61 out of 971 Schwannomas (6.3%) diagnosed during the study period. Out of these 61 cases, 56 (91.8%) were located in the spinal nerve roots. The majority (60.6%) were males. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - October 28, 2015 Category: Pathology Authors: Nasir Ud Din, Zubair Ahmad, Arsalan Ahmed Tags: Original Contribution Source Type: research
The Effect of Neoadjuvant Therapy on the Sıze, Number and Dıstrıbutıon of Mesorectal Lymph Nodes
The current therapeutic approach to the patients with locally advanced rectal cancer (RC) is neoadjuvant radiotherapy (RT) or chemoradiotherapy (CRT) followed by total mesorectal excision. We aimed to investigate the number, size and distribution of metastatic and non-metastatic lymph nodes within the mesorectum; whether neoadjuvant therapy have any impact on the number and size of the lymph nodes and the impact of metastatic lymph node localization on overall (OS) and disease free survival (DFS). (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - October 28, 2015 Category: Pathology Authors: Gülçin Yegen, Metin Keskin, Melek Büyük, Enver Kunduz, Emre Balık, Esra Kaytan Sağlam, Yersu Kapran, Oktar Asoğlu, Mine Güllüoğlu Tags: Original Contribution Source Type: research
The Expression of CD44v6 in Colon: from Normal to Malignant
We examined the immunohistochemical expression of CD44v6 in normal colonic tissue (n=25), hyperplastic polyps (HP, n=45), tubular adenomas (TA, n=57), tubulovillous adenomas (TV, n=25), villous adenomas (VA, n=9), adenocarcinomas stage I (n=26), adenocarcinomas stage III (n=26), and lymph node metastasis (n=26). (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - October 28, 2015 Category: Pathology Authors: Alaa Afify, Blythe Durbin-Johnson, Avnit Virdi, Heidi Jess Tags: Original Contribution Source Type: research
all tumors manifest typical morphological features of myxoinflammatory fibroblastic sarcoma further suggesting two morphological variants of a single entity
We describe 9 cases of pleomorphic hyalinizing angiectatic tumor (PHAT). Recently described TGFBR3 and MGEA5 gene rearrangements in these tumors have confirmed the long hypothesized link between PHAT and another soft tissue entity, the myxoinflammatory fibroblastic sarcoma (MIFS). MIFS and PHAT share the same translocation and in addition have a very similar clinical presentation. However, to our best knowledge, no study has ever addressed the striking morphological similarities between MIFS and PHAT. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - October 28, 2015 Category: Pathology Authors: Michael Michal, Dmitry V. Kazakov, Ladislav Hadravský, Abbas Agaimy, Marián Švajdler, Naoto Kuroda, Michal Michal Tags: Original Contribution Source Type: research
Distinctive Immunostaining of Claudin-4 in Spiradenomas
The intercellular bridges are essential structures in maintaining the histological organization of the epithelium, while providing a very efficient way to exchange molecules between cells and transduction of the cell-to-cell and matrix-to-cell signals. Derangement in those important structures’ physical integrity and/or function, which can be assessed by the presence or absence of several intercellular bridge proteins including Claudin-4, E-Cadherin, and β-Catenin, was found to be related with several phenomena in the path to the neoplastic transformation. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - October 28, 2015 Category: Pathology Authors: Nuri Yiğit, Ertuğrul Çelik, İbrahim Yavan, Armağan Günal, Bülent Kurt, Yıldırım Karslıoğlu, Önder Öngürü, Ayhan Özcan Source Type: research
Carcinoembryonic antigen–related cell adhesion molecule 1 is expressed and as a function histotype in ovarian tumors
Carcinoembryonic antigen–related cell adhesion molecule 1 (CEACAM1) is a cell-cell adhesion receptor and is implicated in several cellular functions. It is rarely reported in ovarian tumors. The aim of this study is to determine the expression of CEACAM1 in ovarian tumors, trying to see whether CEACAM1 has different expression patterns as a function of histotype. Antigen expression was examined by immunohistochemistry with mouse anti-human antibody for CEACAM1. Immunohistochemistry was performed using avidin-biotin-diaminobenzide staining. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - October 27, 2015 Category: Pathology Authors: Ning Li, Jing-yan Yang, Xiao-ying Wang, Hai-tao Wang, Bing-xin Guan, Cheng-jun Zhou Tags: Original Contributions Source Type: research
CEACAM1 is expressed and as a function histotype in ovarian tumors
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is a cell-cell adhesion receptor and is implicated in several cellular functions. It is rarely reported in ovarian tumors. The aim of this study is to determine the expression of CEACAM1 in ovarian tumors, trying to see whether CEACAM1 has different expression patterns as a function of histotype. Antigen expression was examined by immunohistochemistry (IHC) with mouse anti-human antibody for CEACAM1. IHC was performed using avidin-biotin-diaminobenzide staining. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - October 27, 2015 Category: Pathology Authors: Ning Li, Jing-yan Yang, Xiao-ying Wang, Hai-tao Wang, Bing-xin Guan, Cheng-jun Zhou Tags: Original Contributions Source Type: research
