Low-grade metastases in high-grade clear cell renal cell carcinomas A clinico-pathological study of 4 cases with an insight into the role of mesenchymal-to-epithelial transition process

Clear cell renal cell carcinoma (CCRCC) frequently develops distant metastases. However, high-grade primary CCRCC rarely leads to low-grade metastases. Cellular changes occurring during neoplastic progression known as epithelial-to-mesenchymal (EMT) and mesenchymal-to-epithelial (MET) transitions explain this apparent contradiction. Four high-grade CCRCC which lead to low-grade metastases is analyzed in this study with the focus on EMT and MET processes. Clinico-pathological data have been collected retrospectively and immunohistochemistry performed with E-Cadherin, N-Cadherin, Vimentin and WT-1.
Source: Annals of Diagnostic Pathology - Category: Pathology Authors: Tags: Original Contribution Source Type: research