Distinctive Immunostaining of Claudin-4 in Spiradenomas

The intercellular bridges are essential structures in maintaining the histological organization of the epithelium, while providing a very efficient way to exchange molecules between cells and transduction of the cell-to-cell and matrix-to-cell signals. Derangement in those important structures’ physical integrity and/or function, which can be assessed by the presence or absence of several intercellular bridge proteins including Claudin-4, E-Cadherin, and β-Catenin, was found to be related with several phenomena in the path to the neoplastic transformation.

Source: Annals of Diagnostic Pathology - October 28, 2015 Category: Pathology Authors: Nuri Yiğit, Ertuğrul Çelik, İbrahim Yavan, Armağan Günal, Bülent Kurt, Yıldırım Karslıoğlu, Önder Öngürü, Ayhan Özcan Source Type: research