Human intestinal spirochetosis: right-side preference in the large intestine
Human intestinal spirochetosis (HIS) is a colorectal bacterial infection, and its clinicopathologic features remain unclear. The aim of this study was to examine its characteristics. We histologically reviewed paraffin-embedded section-slides made in 2001, 2006, and 2011 at a single institution in Japan. Cases histologically exhibiting a distinct fringe-formation were considered to have HIS. Information was obtained from pathology request forms. We identified 85 HIS cases among 4,930 patients [7 cases (0.5 %) in 2001, 29 (1.7 %) in 2006, and 49 (2.8 %) in 2011]. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - October 21, 2015 Category: Pathology Authors: Sho Ogata, Ken Shimizu, Kuniaki Nakanishi Source Type: research
Antisecretory medication is associated with decreased detection in gastric marginal zone lymphoma
Helicobacter pylori status influences the prognosis and management of gastric extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma), so accurate determination of H pylori status is of clinical importance. The low rate of histologic H pylori positivity among gastric MALT lymphoma cases at our institution prompted investigation for possible causes. A case series of 24 patients as having gastric MALT lymphoma (with no diffuse large B-cell component) in a tertiary care setting between 1997 and 2010 was identified, and clinical records were reviewed. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - October 12, 2015 Category: Pathology Authors: Kurt B. Schaberg, Mark F. Evans, Rebecca Wilcox, Michael R. Lewis Tags: Original Contribution Source Type: research
Anti-secretory medication is associated with decreased detection in gastric marginal zone lymphoma
Helicobacter pylori status influences the prognosis and management of gastric extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma), so accurate determination of H. pylori status is of clinical importance. The low rate of histologic H. pylori positivity among gastric MALT lymphoma cases at our institution prompted investigation for possible causes. A case series of 24 patients diagnosed with gastric MALT lymphoma (with no diffuse large B-cell component) in a tertiary care setting between 1997 and 2010 was identified, and clinical records were reviewed. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - October 12, 2015 Category: Pathology Authors: Kurt B. Schaberg, Mark F. Evans, Rebecca Wilcox, Michael R. Lewis Tags: Original Contribution Source Type: research
Influence of AIDS in collagen deposition and thickness of the bone marrow
Bone marrow abnormalities are frequently observed in individuals with acquired immunodeficiency syndrome (AIDS). Dysplasia, the most common abnormality, is found in more than 50% of patients infected with the human immunodeficiency virus (HIV). The aim of this study was to assess trabecular thickness and collagen content as well as cellularity in the bone marrow of patients with AIDS. Sixty bone marrow samples were collected from the sternum of autopsied patients with or without AIDS (n=30, each). (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - October 10, 2015 Category: Pathology Authors: Natália Ferreira Ribeiro Dias, Guilherme Ribeiro Juliano, Ana Paula Espindula, Flávia Aparecida de Oliveira, Lívia Ferreira Oliveira, Camila Lourencini Cavellani, Luciana Santos Ramalho, Vicente de Paula Antunes Teixeira, Mara Lúcia da Fonseca Ferraz Source Type: research
Aberrant membranous expression of -catenin predicts poor prognosis in patients with craniopharyngioma
The objective of this study is to investigate β-catenin expression in craniopharyngioma patients and determine its significance in predicting the prognosis of this disease. Fifty craniopharyngioma patients were enrolled in this study. Expression of β-catenin in tumor specimens collected from these patients was examined through immunostaining. In addition, mutation of exon 3 in the β-catenin gene, CTNNB1, was analyzed using polymerase chain reaction, denaturing high-pressure liquid chromatography, and DNA sequencing. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - October 9, 2015 Category: Pathology Authors: Zongping Li, Jianguo Xu, Siqing Huang, Chao You Tags: Original Contribution Source Type: research
Aberrant membranous expression of β-catenin predicts poor prognosis in patients with craniopharyngioma
The objective of this study is to investigate β-catenin expression in craniopharyngioma patients and determine its significance in predicting the prognosis of this disease. Fifty craniopharyngioma patients were enrolled in this study. Expression of β-catenin in tumor specimens collected from these patients was examined through immunostaining. In addition, mutation of exon 3 in the β-catenin gene, CTNBB1, was analyzed using PCR, denaturing high pressure liquid chromatography (DHPLC), and DNA sequencing. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - October 9, 2015 Category: Pathology Authors: Zongping Li, Jianguo Xu, Siqing Huang, Chao You Tags: Original Contribution Source Type: research
Editorial Board
(Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - September 14, 2015 Category: Pathology Source Type: research
Masthead
(Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - September 14, 2015 Category: Pathology Source Type: research
Table of Contents
(Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - September 14, 2015 Category: Pathology Source Type: research
The pattern of CD44 and matrix metalloproteinase 9 expression is a useful predictor of ulcerative colitis–associated dysplasia and neoplasia
Ulcerative colitis (UC)–associated neoplasia presumably evolves through a chronic inflammation–dysplasia–adenocarcinoma sequence in which a corporation of several factors takes place. The grade of dysplasia is important in further development of colorectal cancer. CD44 is a cell adhesion molecule and acts as a docking receptor for matrix metalloproteinase 9 (MMP-9). The aims of this study are to assess UC-associated dysplasia and to distinguish regenerative changes from premalignant ones through detecting pattern of CD44 and MMP-9 expression in different UC lesions. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - August 26, 2015 Category: Pathology Authors: Marwa A. AbdElazeem, Mona El-Sayed Tags: Original Contribution Source Type: research
Phosphaturic mesenchymal tumors. Survey of 8 cases from a single Mexican medical institution
Phosphaturic mesenchymal tumor (PMT) is a morphologically heterogeneous soft tissue and bone neoplasm, producing a paraneoplastic syndrome due to phosphate wasting. These tumors produce fibroblast growth factor 23, which is implicated in renal tubule phosphate loss. Medical records of patients seen from 1999 to 2013 with osteomalacia associated or not with a tumor were reviewed. Clinical and laboratory data, radiographic studies, and follow-up of 8 patients were tabulated. Histologic features and the immunoprofile of the tumors were analyzed. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - August 26, 2015 Category: Pathology Authors: Arturo Angeles-Angeles, Alfredo Reza-Albarrán, Fredy Chable-Montero, Juan Carlos Cordova-Ramón, Jorge Albores-Saavedra, Braulio Martinez-Benitez Tags: Original Contributions Source Type: research
Next-Generation Sequencing Reveals Rare Genomic Alterations in Aggressive Digital Papillary Adenocarcinoma
Aggressive digital papillary adenocarcinoma (ADPA) is a rare cutaneous adnexal neoplasm that occurs on the fingers, toes, palms, and soles. It is characterized by aggressive biological behavior, with a relatively high potential for local recurrence (30%-40% of cases) and distant metastasis (up to 14%). This retrospective study assessed the mutation status of ADPA lesions to identify possible therapeutic targets. We performed comprehensive genomic profiling of 9 ADPA cases that had been identified in our database. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - August 26, 2015 Category: Pathology Authors: Diana Bell, Phyu Aung, Victor G. Prieto, Doina Ivan Tags: Original Contribution Source Type: research
Phosphaturic mesenchymal tumors. Survey of eight cases from a single Mexican Medical institution
Phosphaturic mesenchymal tumor (PMT) is a morphologically heterogeneous soft tissue and bone neoplasm, producing a paraneoplastic syndrome due to phosphate wasting. These tumors produce fibroblast growth factor 23, which is implicated in renal tubule phosphate loss. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - August 26, 2015 Category: Pathology Authors: Arturo Angeles-Angeles, Alfredo Reza-Albarrán, Fredy Chable-Montero, Juan Carlos Cordova-Ramón, Jorge Albores-Saavedra, Braulio Martinez-Benitez Tags: Original Contributions Source Type: research
The Pattern of CD44 and Matrix Metaloproteinase-9 Expression is a Useful Predictor of Ulcerative Colitis Associated Dysplasia and Neoplasia
Ulcerative colitis (UC) associated neoplasia presumably evolves through a chronic inflammation–dysplasia–adenocarcinoma sequence in which a corporation of several factors takes place. The grade of dysplasia is important in further development of colorectal cancer.CD44 is a cell adhesion molecule and acts as a docking receptor for Matrix metalloproteinase-9 (MMP-9). (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - August 26, 2015 Category: Pathology Authors: Marwa A. AbdElazeem, Mona El-Sayed Tags: Original Contribution Source Type: research
Detecting intratumoral heterogeneity in routine breast-HER2 testing: low yield of testing multiple blocks
Intratumoral heterogeneity can lead to uncertainty in breast carcinoma HER2 testing, both with respect to pathology reporting and clinical significance. The standard practice is to perform breast biomarker testing on a single representative section of tumor; however, concern over heterogeneity often leads to testing on additional tissue blocks. Our objective was to assess the diagnostic yield of testing multiple blocks of a single invasive breast carcinoma. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - August 14, 2015 Category: Pathology Authors: Gillian C. Bethune, J. Brendan Mullen, Martin C. Chang Source Type: research
