Next-Generation Sequencing Reveals Rare Genomic Alterations in Aggressive Digital Papillary Adenocarcinoma

Aggressive digital papillary adenocarcinoma (ADPA) is a rare cutaneous adnexal neoplasm that occurs on the fingers, toes, palms, and soles. It is characterized by aggressive biological behavior, with a relatively high potential for local recurrence (30%-40% of cases) and distant metastasis (up to 14%). This retrospective study assessed the mutation status of ADPA lesions to identify possible therapeutic targets. We performed comprehensive genomic profiling of 9 ADPA cases that had been identified in our database.
Source: Annals of Diagnostic Pathology - Category: Pathology Authors: Tags: Original Contribution Source Type: research