CD30+ T cell enriched primary cutaneous CD4+ small/medium sized pleomorphic T cell lymphoma: A distinct variant of indolent CD4+ T cell lymphoproliferative disease
Primary cutaneous CD4+ small/medium sized pleomorphic T-cell lymphoma (SMPTCL) is unique among the peripheral T-cell lymphomas because of its indolent nature, typically presenting as a solitary nodule or plaque in the head and neck area of middle-aged and older adults. Recent studies have suggested a follicular helper cell origin for these lesions. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - April 27, 2017 Category: Pathology Authors: Cynthia M. Magro, Luke C. Olson, Clifton Fulmer Source Type: research
Evaluation of CD43 expression in non-hematopoietic malignancies
CD43 is normally expressed only on the surface of leukocytes, and is considered a sensitive and specific marker for hematologic malignancies. As such, it may have diagnostic utility in confirming hematolymphoid lineage in cases that are negative for CD45. Aberrant CD43 expression has been described in non-hematopoietic tumors, although literature data on this topic is variable and sometimes contradictory. To clarify and expand on existing literature findings, we evaluated CD43 expression by immunohistochemistry (IHC) in a large cohort (307) of non-hematopoietic neoplasms, including poorly differentiated malignancies. (Sour...
Source: Annals of Diagnostic Pathology - April 26, 2017 Category: Pathology Authors: Bjorn H. Batdorf, Steven H. Kroft, Paul R. Hosking, Alexandra M. Harrington, Alexander C. Mackinnon, Horatiu Olteanu Source Type: research
Programmed death-1 (PD-1) receptor/PD-1 ligand (PD-L1) expression in fumarate hydratase-deficient renal cell carcinoma
Fumarate hydratase-deficient renal cell carcinoma (FH-RCC) is a rare and aggressive tumor affecting mostly younger patients. This is the first study to assess the expression of programmed death-1 (PD-1) receptor/PD-1 ligand (PD-L1) in FH-RCC.Formalin-fixed paraffin-embedded samples from 13 FH-RCCs collected in an international multi-institutional study, were evaluated by immunohistochemistry (IHC) for PD-1/PD-L1 reactivity in tumor cells and tumor infiltrating lymphocytes (TILs). PD-1/PD-L1 expression was further evaluated by qPCR. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - April 24, 2017 Category: Pathology Authors: Reza Alaghehbandan, Jan Stehlik, Kiril Trpkov, Cristina Magi-Galluzzi, Enric Condom Mundo, Maria Pane Foix, Daniel Berney, Mathilde Sibony, Saul Suster, Abbas Agaimy, Delia Perez Montiel, Kristyna Pivovarcikova, Kvetoslava Michalova, Ondrej Daum, Ondrej O Source Type: research
Cyclin D1 is significantly associated with stage of tumor and predicts poor survival in endometrial carcinoma patients
This study will describe the immunohistochemical phenotype of cyclin D1, and investigate the correlation between these patterns of expression and clinicopathological parameters of endometrial carcinomas, to conclude the clinical relevance of cyclin D1 expression in the evolution of endometrial neoplasms. This study employed 101 endometrial tissue samples which include 71 endometrial carcinomas and thirty normal and benign endometrium cases. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - April 20, 2017 Category: Pathology Authors: Mohamad Nidal Khabaz, Amer Shafie Abdelrahman, Nadeem Shafique Butt, Basim Al-Maghrabi, Jaudah Al-Maghrabi Source Type: research
Application of a time-resolved fluoroimmunoassay for detection of p16INK4a in cervix
Objective: To establish a time-resolved fluoroimmunoassay (TRFIA) method to detect p16INK4a. Methods: 119 cases of exfoliative cells following Thinprep cytologic test (TCT) test were selected for TRFIA and biopsy tissues of these patients according to TCT results were collected for immunohistochemical (IHC) staining. Results: There were 40 cases with cervicitis, 16 cases of cervical intraepithelial neoplasia grade 1 (CIN1), 15 cases of CIN2, 26 cases of CIN3, and 22 cases of squamous cell carcinoma (SCC). (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - April 13, 2017 Category: Pathology Authors: Ding Li, Chen Qiong, Fan Wanting, Zou Xianjin Source Type: research
Recent updates on grading and classification of neuroendocrine tumors
Neuroendocrine tumors (NETs) are originating from neuroendocrine cells in diffuse endocrine systems. NETs are diagnosed by characteristic histologic features and immunoprofiles. Recent 2010 WHO classification for gastroenteropancreatic NETs introduced grading system based on mitotic count and Ki-67 proliferation index. Gastroenteropancreatic NETs are classified as NET grade 1, NET grade 2, and neuroendocrine carcinoma (NET grade 3). However, the carcinoid is still used in classification of NETs of the lung and uterine cervix. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - April 13, 2017 Category: Pathology Authors: Joo Young Kim, Seung-Mo Hong, Jae Y. Ro Source Type: research
Increased CD105 expression is associated with disease progression in phyllodes tumors - A report of a borderline phyllodes tumor with lung metastases and a study of 54 phyllodes tumors
Phyllodes tumors are rare biphasic neoplasms that account for (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - April 8, 2017 Category: Pathology Authors: Kangyu Wang, Qianhua Li, Ranran Shi, Dandan Yang, Wenlu Zou, Kun Mu Source Type: research
A semi-quantitative World Health Organization grading scheme evaluating worst tumor differentiation predicts disease-free survival in oral squamous carcinoma patients
We investigated World Health Organization (WHO) grading and pattern of invasion based histological schemes as independent predictors of disease-free survival, in oral squamous carcinoma patients. Tumor resection slides of eighty-seven oral squamous carcinoma patients [pTNM: I&II/III&IV-32/55] were evaluated. Besides examining various patterns of invasion, invasive front grade, predominant and worst (highest) WHO grade were recorded. For worst WHO grading, poor-undifferentiated component was estimated semi-quantitatively at advancing tumor edge (invasive growth front) in histology sections. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - April 8, 2017 Category: Pathology Authors: Dhruv Jain, Gargi Tikku, Pallavi Bhadana, Chandrashekhar Dravid, Rajesh Kumar Grover Source Type: research
Low-grade fibromyxoid sarcoma: Clinical, morphologic and genetic features
Low-grade fibromyxoid sarcoma (LGFMS) is a bland spindle cell neoplasm that typically arises in the deep soft tissues of the proximal extremities or trunk of young adults. The majority of LGFMS are characterized by a recurrent (7;16)(q34;p11) translocation, resulting in the FUS-CREB3L2 fusion gene, which generates a chimeric protein with transcriptional regulatory activity. Small numbers harbor a FUS-CREB3L1 fusion resulting from t(11;16)(p11;p11), whilst rare cases harbor the EWSR1-CREB3L1 fusion. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - April 5, 2017 Category: Pathology Authors: Mustafa Mohamed, Cyril Fisher, Khin Thway Source Type: research
Editorial Board
(Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - April 1, 2017 Category: Pathology Source Type: research
Masthead
(Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - April 1, 2017 Category: Pathology Source Type: research
Table of Contents
(Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - April 1, 2017 Category: Pathology Source Type: research
Instructions to Authors
(Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - April 1, 2017 Category: Pathology Source Type: research
Lymphoid malignancy-associated hemophagocytic lymphohistiocytosis: Search for the hidden source
Secondary hemophagocytic lymphohistiocytosis (HLH) is an uncommon, but life-threatening syndrome of highly stimulated and ineffective immune dysregulation. It is not a disease entity by itself and the current diagnosis of secondary (acquired) HLH is based on constellation of nonspecific clinical and laboratory parameters indicative of overactive immune response. The presenting symptoms are often nonspecific and could potentially be missed, leading to a fatal outcome. Patients with malignancy-associated HLH have a relatively unfavorable overall survival compared with non-malignancy-associated HLH. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - February 18, 2017 Category: Pathology Authors: Ashish Bains, Linda Mamone, Amandeep Aneja, Michael Bromberg Source Type: research
Primary cutaneous interdigitating dendritic cell sarcoma is a morphologic and phenotypic simulator of poorly differentiated metastatic melanoma: A report of 2 cases and review of the literature
Interdigitating dendritic cell sarcoma (IDS) is a rare form of hematologic malignancy associated with an aggressive clinical course. Only 4 prior cases have been described as originating in the skin. We encountered two male patients ages 47 and 61years of age who presented with solitary cutaneous neoplasms diagnosed as IDS. Histologic exam showed a coalescing nested and multinodular proliferation of large pleomorphic epithelioid cells. In one case an initial diagnosis of melanoma was rendered. A recurrence 8months later was then interpreted as a primary cutaneous IDS. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - February 18, 2017 Category: Pathology Authors: Cynthia M. Magro, Luke C. Olson, Gerard Nuovo, Garron Solomon Source Type: research
