Intraductal tubular neoplasms of the pancreas: an overview
Intraductal lesions of the pancreas are an uncommon but increasingly recognized group of entities mainly because of advances in imaging technology. In the past, precise categorization and understanding of true pancreatic intraduct neoplasms were hampered not only by their relative rarity but also because of the plethora of terminology and criteria used in nomenclature and diagnosis. Although significant progress has been made in the characterization of some of these lesions, as exemplified by intraductal papillary mucinous neoplasms, understanding of the rare intraductal tubular adenoma (ITA) and intraduct tubular carcinom...
Source: Annals of Diagnostic Pathology - April 24, 2016 Category: Pathology Authors: Adeline Chelliah, Sangeetha Kalimuthu, Runjan Chetty Source Type: research
Intraductal Tubular Neoplasms of the Pancreas: an Overview
Intraductal lesions of the pancreas are an uncommon but increasingly recognized group of entities, mainly due to advances in imaging technology. In the past, precise categorization and understanding of true pancreatic intraduct neoplasms was hampered not only by their relative rarity but also due to the plethora of terminology and criteria used in nomenclature and diagnosis. Whilst significant progress has been made in the characterization of some of these lesions, as exemplified by intraductal papillary mucinous neoplasms (IPMN), understanding of the rare intraductal tubular adenoma (ITA) and intraduct tubular carcinoma (...
Source: Annals of Diagnostic Pathology - April 24, 2016 Category: Pathology Authors: Adeline Chelliah, Sangeetha Kalimuthu, Runjan Chetty Source Type: research
C-met expression and MET amplification in malignant pleural mesothelioma
We report the first case of MET amplification in sarcomatoid MPM.MPMs from surgical pathology files (1989–2014) were reviewed. c-Met immunohistochemistry was performed. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - April 14, 2016 Category: Pathology Authors: Melanie C. Bois, Aaron S. Mansfield, William R. Sukov, Sarah M. Jenkins, Justin C. Moser, Christopher A. Sattler, Carin Y. Smith, Julian R. Molina, Tobias Peikert, Anja C. Roden Source Type: research
Cutaneous hidradenoma: A study of 21 neoplasms revealing neither correlation between the cellular composition and CRTC1-MAML2 fusions nor presence of CRTC3-MAML2 fusions
Twenty-one hidradenomas from 20 patients (13 female, 7 male) ranging in age from 18 to 87years (mean 57.75yrs., median 60yrs) were studied for CRTC1-MAML2 and CRTC3-MAML2 fusions to find out whether there is a correlation between the particular cell type (polyhedral eosinophilic, clear, mucinous, epidermoid, and oncocytic) and presence the above alterations. CRTC1-MAML2 fusions were detected in 10 of the 21 neoplasms (47.6%). FISH for MAML2 break apart was analyzable in 13 specimens and in all these specimens was positive, including 4 tumors with no demonstrable CRTC1-MAML2 fusion. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - April 14, 2016 Category: Pathology Authors: Liubov Kyrpychova, Denisa Kacerovska, Tomas Vanecek, Petr Grossmann, Michal Michal, Katrin Kerl, Dmitry V. Kazakov Source Type: research
Clinicopathologic and radiologic features of extraskeletal myxoid chondrosarcoma: a retrospective study of 40 Chinese cases with literature review
The aim of this study is to describe the clinicopathologic and radiologic features of 40 cases of extraskeletal myxoid chondrosarcoma (EMC) from China. There were 25 males and 15 females (sex ratio, 1.7:1). Apart from an adolescent, all patients were adults with a median age of 49years. Twenty-four tumors (60%) occurred in the lower limb and limb girdles, especially the thigh, followed by the upper limb and limb girdles (20%) and trunk (10%). Other less commonly involved locations included the head and neck, sacrococcygeal region, and perineum. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - April 12, 2016 Category: Pathology Authors: Rui Shao, I Weng Lao, Lei Wang, Lin Yu, Jian Wang, Qinhe Fan Source Type: research
Clinicopathological and radiological features of extraskeletal myxoid chondrosarcoma: A retrospective study of 40 Chinese cases with literature review
The aim of this study is to describe the clinicopathological and radiological features of 40 cases of extraskeletal myxoid chondrosarcoma (EMC) from China. There were 25 males and 15 females (gender ratio 1.7:1). Apart from an adolescent, all patients occurred in adults with a median age of 49years. Twenty four tumors (60%) occurred in the lower limb and limb girdles, especially the thigh, followed by the upper limb and limb girdles (20%) and trunk (10%). Other less commonly involved locations included the head and neck, sacrococcygeal region and perineum. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - April 12, 2016 Category: Pathology Authors: Rui Shao, I. Weng Lao, Lei Wang, Lin Yu, Jian Wang, Qinhe Fan Source Type: research
Tubulosquamous polyps in the vagina. Immunohistochemical comparison with ectopic prostatic tissue and Skene glands
Two tubulosquamous polyps arising in the vagina are reported. Both were diffusely positive for GATA3 in the squamous component and focally positive for NKX3.1 in the glandular component, prostate acid phosphatase was focally positive in only 1 case in the glandular component. Both cases were negative for PAX2, PAX8, SALL4, and prostate-specific antigen. In addition, we included 3 cases of cervical squamous-lined cysts most likely representing ectopic prostatic tissue in the cervix and 1 case of paraurethral Skene-type glands to compare the immunophenotype. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - April 11, 2016 Category: Pathology Authors: Andres A. Roma Source Type: research
Tubulo-squamous polyps in the vagina. Immunohistochemical comparison with ectopic prostatic tissue and skene glands
Two tubulo-squamous polyps arising in the vagina are reported. Both were diffusely positive for GATA3 in the squamous component and focally positive for NKX3.1 in the glandular component; PrAP was focally positive in only one case in the glandular component. Both cases were negative for PAX2, PAX8, SALL4 and PSA. In addition, we included three cases of cervical squamous-lined cysts most likely representing ectopic prostatic tissue in the cervix and one case of paraurethral Skene-type glands to compare the immunophenotype. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - April 11, 2016 Category: Pathology Authors: Andres A. Roma Source Type: research
Utility of Peritoneal Washing Cytology in Staging and Prognosis of Ovarian and Fallopian Tube Neoplasms: A 10-year Retrospective Analysis
In this study, we retrospectively reviewed all cases of ovarian and fallopian tube neoplasms in which cytological studies were performed. The utility of cytology in tumor staging and the relationship between cytology results and patient outcome are studied. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - April 10, 2016 Category: Pathology Authors: Whitney Davidson, Rashna Madan, Maura O’Neil, Ossama W. Tawfik, Fang Fan Source Type: research
Mammary analogue secretory carcinoma of salivary glands: A clinicopathologic study of 11 cases
Mammary analogue secretory carcinoma (MASC) is a recently described tumor sharing the histologic, immunohistochemical and molecular profile of secretory carcinoma of breast. We aimed to evaluate the morphologic and histochemical features needed/required for the diagnosis of MASC without adjunct of molecular analysis. Six retrospective cases suspicious for MASC and 5 prospective cases reported as MASC were included in the study. Molecular analysis of ETV6 by FISH was performed at University of Pittsburg, USA. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - April 10, 2016 Category: Pathology Authors: Nasir Ud Din, Saira Fatima, Naila Kayani Source Type: research
Ectopic Primary Olfactory Neuroblastoma of the Maxillary Sinus
We report a case of ONB in the maxillary sinus. A 63-year-old female presented with left sided nasal obstruction and epistaxis. MRI showed a nonenhancing left maxillary sinus tumor. Histologic sections showed ONB, Hyams grade IV, invading bone, skeletal muscle and adjacent fibroadipose tissue. It is essential to be accurate when diagnosing sinonasal tumors since the differential diagnosis is broad and one must consider the possibility of ectopic ONB, although it is rare. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - April 10, 2016 Category: Pathology Authors: Margaret Holmes, Shirley Y. Su, Diana Bell Source Type: research
Advances in B-lymphoblastic leukemia: Cytogenetic and genomic lesions
The genomic profiling of B-cell lymphoblastic leukemia (B-ALL) subtypes are characterized by a constellation of genetic changes involving structural rearrangements, submicroscopic DNA copy number alterations, and sequence mutations. Several of these genetic changes have relevant implications for risk stratification and targeted therapeutic interventions. In this review, we summarize some of the well-known and recently identified genomic risk factors for B-ALL, with emphasis on their associated prognoses and methods of detection. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - April 8, 2016 Category: Pathology Authors: Yi Zhou, Rashmi Kanagal-Shamanna, Zhuang Zuo, Guilin Tang, L. Jeffrey Medeiros, Carlos E. Bueso-Ramos Source Type: research
The Correlation of Sodium Iodide Symporter and BRAFV600E Mutation in Classical Variant Papillary Thyroid Carcinoma
BRAFV600E mutation was analyzed by real time PCR in 96 consecutive cases with CV-PTC and immunohistochemical staining of NIS protein was evaluated. Localization(intracellular or membranous), density and the intensity of cytoplasmic staining were characterized semi quantitatively. Extrathyroidal invasion, surgical margin positivity, lymph node metastasis was compared with BRAFV600E mutation and NIS expression. 88 patients who had at least 24 months follow up were also included in survival analysis. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - April 8, 2016 Category: Pathology Authors: Aylin Yazgan, Nilüfer Yıldırım, Ayşegül Gözalan, Sinem Gümüştaş, Aydan Kılıçarslan, Serdar Balci, Cevdet Aydın, Reyhan Ersoy, Bekir Cakir, Gülnur Güler Source Type: research
Bmi-1 expression predicts prognosis in salivary adenoid cystic carcinoma and correlates with EMT-related factors
Salivary adenoid cystic carcinoma (AdCC) is known for its high propensity to invade and metastasize. Bmi-1 acts as an oncogene by controlling cell cycle and self-renewal of adult stem cells, and its overexpression correlates with metastasis and poor prognosis in several cancers. Epithelial-mesenchymal transition (EMT) plays a central role in cancer metastasis. A key step in EMT is the down-regulation of E-cadherin that can be repressed by the transcriptional factors, such as Snail and Slug. In the present study, we investigated Bmi-1, Snail, Slug and E-cadherin expression by immunohistochemistry in 102 patients with AdCC a...
Source: Annals of Diagnostic Pathology - March 21, 2016 Category: Pathology Authors: Chun Yi, Bin-bin Li, Chuan-Xiang Zhou Source Type: research
Bmi-1 expression predicts prognosis in salivary adenoid cystic carcinoma and correlates with epithelial-mesenchymal transition–related factors
Salivary adenoid cystic carcinoma (AdCC) is known for its high propensity to invade and metastasize. Bmi-1 acts as an oncogene by controlling cell cycle and self-renewal of adult stem cells, and its overexpression correlates with metastasis and poor prognosis in several cancers. Epithelial-mesenchymal transition (EMT) plays a central role in cancer metastasis. A key step in EMT is the down-regulation of E-cadherin that can be repressed by the transcriptional factors, such as Snail and Slug. In the present study, we investigated Bmi-1, Snail, Slug, and E-cadherin expression by immunohistochemistry in 102 patients with AdCC ...
Source: Annals of Diagnostic Pathology - March 20, 2016 Category: Pathology Authors: Chun Yi, Bin-bin Li, Chuan-Xiang Zhou Source Type: research
