all tumors manifest typical morphological features of myxoinflammatory fibroblastic sarcoma further suggesting two morphological variants of a single entity

We describe 9 cases of pleomorphic hyalinizing angiectatic tumor (PHAT). Recently described TGFBR3 and MGEA5 gene rearrangements in these tumors have confirmed the long hypothesized link between PHAT and another soft tissue entity, the myxoinflammatory fibroblastic sarcoma (MIFS). MIFS and PHAT share the same translocation and in addition have a very similar clinical presentation. However, to our best knowledge, no study has ever addressed the striking morphological similarities between MIFS and PHAT.

Source: Annals of Diagnostic Pathology - October 28, 2015 Category: Pathology Authors: Michael Michal, Dmitry V. Kazakov, Ladislav Hadravský, Abbas Agaimy, Marián Švajdler, Naoto Kuroda, Michal Michal Tags: Original Contribution Source Type: research