Intralymphatic Nevus Cells in Benign Nevi

The histogenesis of nevus cell aggregates in lymph nodes lesion is controversial and various hypotheses have been used to explain their origin. One of them is the transport of cells from cutaneous nevi or lesions to lymph nodes, called mechanical transport theory. We investigated in our cases of benign nevi to obtain evidence to substantiate this theory. 369 benign cutaneous nevi were prospectively evaluated in excisional biopsy samples. Immunohistochemical stainings for CD31 and podoplanin (D2 –40) were performed in the cases with intralymphatic nevus cell aggregate (ILNA), suspected for ILNA and/or intralymphatic nevus cell protrusion (ILNP).

Source: Annals of Diagnostic Pathology - August 17, 2016 Category: Pathology Authors: Cem Leblebici, Canan Kelten, Mehmet Salih Gurel, Ezgi Hac ıhasasanoglu Source Type: research