Angiosarcoma Arising in Association with Vascular Dacron Grafts and Orthopedic Joint Prostheses: Clinicopathologic, Immunohistochemical and Molecular Study

Angiosarcoma may rarely arise in close proximity to inert foreign body material including vascular grafts and metal joint prostheses. 16 such cases have been reported since 1972 but mostly in the radiological or surgical literature without detailed histological or molecular analyses. We herein describe the clinicopathologic and molecular features of 2 new cases and reanalyzed 3 previously reported cases of angiosarcoma that developed in association with Dacron grafts for vascular repair (n=3) or related to orthopedic metal prostheses for joint replacement (n=2).
Source: Annals of Diagnostic Pathology - Category: Pathology Authors: Source Type: research