Heterogeneity of Promoter Mutations Status in Squamous Cell Carcinomas of Different Anatomical Sites

Squamous cell carcinoma (SCC) can arise from different anatomic sites including skin, head & neck, lung, esophagus and genital area etc. Despite the same histopathological features and immunohistochemistry profile, the SCCs of different body sites can show tremendous differences in their presenting symptoms, risk factor associations, natural history, prognosis, and response to treatment. This may reflect the fact that SCCs are heterogenous and likely have unique molecular characteristics at different anatomical sites.
Source: Annals of Diagnostic Pathology - Category: Pathology Authors: Tags: Original Contribution Source Type: research