Cutaneous Myeloid Dendritic Cell dyscrasia: A Cutaneous Clonal Monocytosis Associated with Chronic Myeloproliferative Disorders and Peripheral Blood Monocytosis

Monocytes are critical components of the innate immune system and they can differentiate into dendritic cells (DCs). Cutaneous neoplasms of dendritic cell origin are uncommon and mostly represented by histiocytic lesions derived primarily from Langerhans cells. The myeloid DC (mDC) while recognized in the immunology literature does not have a well-defined neoplastic cutaneous counterpart. Eleven patients with a diagnosis of cutaneous mDC dyscrasia were evaluated. Routine hematoxylin and eosin stain were performed followed by selective phenotypic studies.
Source: Annals of Diagnostic Pathology - Category: Pathology Authors: Source Type: research