Cyclin D1 expression and polysomy in lymphocyte-predominant cells of nodular lymphocyte-predominant Hodgkin lymphoma

Cyclin D1 protein expression in lymphocytes is classically associated with mantle cell lymphoma. Although increasingly recognized in other lymphoproliferative disorders, cyclin D1 expression and CCND1 gene abnormalities have not been well studied in nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL). Using a double stain for CD20/cyclin D1, we quantified cyclin D1 expression in 10 cases of NLPHL and correlated those findings with SOX11 expression, CCND1 gene abnormalities, and clinical data.

Source: Annals of Diagnostic Pathology - October 6, 2016 Category: Pathology Authors: Benjamin B. Cho, Sarah M. Kelting, Alejandro A. Gru, Robin D. LeGallo, Patcharin Pramoonjago, Teresa A. Goldin, Christopher T. Heitz, Nadine S. Aguilera Tags: Original Contribution Source Type: research