Chronic myeloid leukemia with a rare fusion transcript, e19a2 BCR –ABL1: A report of three cases from India

The μ-bcr breakpoint connects exon 19 of BCR with ABL giving rise to the e19a2 transcript corresponding to the p230 fusion protein (micro-BCR breakpoint) which is rarely seen in chronic myeloid leukemia (CML) patients. Here we report three patients with p230 fusion protein presenting with different cli nical presentations and diagnosed as CML-CP. These patients received Imatinib (tyrosine kinase inhibitor-TKI) and are still in remission.

Source: Annals of Diagnostic Pathology - December 14, 2016 Category: Pathology Authors: Sudha Sazawal, Sunita Chikkara, Kanwaljeet Singh, Rekha Chaubey, Dinesh Chandra, Pravas Mishra, Manoranjan Mahapatra, Tulika Seth, Renu Saxena Source Type: research