Anaplastic lymphoma kinase gene expression in small round cell tumors of childhood—a comparative ımmunohistochemical study

The focus of this study was to investigate anaplastic lymphoma kinase (ALK) expression by immunohistochemistry using a highly specific antibody. Distribution and frequency of ALK expression may provide a clue for ALK inhibitor use in small round cell tumors of childhood. The study group involved 76 small round cell tumors of childhood, which composed of 11 rhabdomyosarcomas, 13 Wilms tumors, 7 Ewing sarcoma/primitive neuroectodermal tumors, 34 peripheral neuroblastic tumors, and 11 acute lymphoblastic lymphoma.
Source: Annals of Diagnostic Pathology - Category: Pathology Authors: Tags: Original Contribution Source Type: research