Immunohistochemical Evaluation of the GABAergic Neuronal System in the Prefrontal Cortex of a DISC1 Knockout Mouse Model of Schizophrenia
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Using the animal model mice of schizophrenia, the authors have investigated the expression of PV (Parvalbumin) and Calbindin D28k in the prefrontal cortex, and compared to those of wild‐type mice. The densities of both PV‐ and Calbindin‐ neurons were lower in model mice than in wild‐type mice. (Source: Synapse)
Source: Synapse - July 16, 2016 Category: Neurology Authors: Kentaro Umeda, Shuji Iritani, Hiroshige Fujishiro, Hirotaka Sekiguchi, Youta Torii, Chikako Habuchi, Keisuke Kuroda, Kozo Kaibuchi, Norio Ozaki Tags: Research Article Source Type: research
Issue Information
(Source: Synapse)
Source: Synapse - July 13, 2016 Category: Neurology Tags: Issue Information Source Type: research
Investigation of the role of alpha‐2 adrenergic receptors on prepulse inhibition of acoustic startle reflex in rats
Conclusion: Because idazoxan and clonidine also act through imidazoline receptors, our results suggest that alpha‐2 and/or imidazoline receptors are associated with PPI of acoustic startle reflex in rats. Stimulation of these receptors may cause sensorimotor gating disturbances. This article is protected by copyright. All rights reserved.
GRAPHICAL ABSTRACT
Clonidine, an alpha‐2 agonist, produced significant disruptions in PPI of rats. This effect was reversed by specific antagonist idazoxan (figure). Thus, alpha‐2 adrenergic receptor stimulation may cause sensorimotor gating disturbances. (Source: Synapse)
Source: Synapse - July 11, 2016 Category: Neurology Authors: Ayse Ozcetin, Burcu Cevreli, Tayfun Uzbay Tags: Research Article Source Type: research
Estimating the effect of endogenous dopamine on baseline [11C] ‐(+)‐PHNO binding in the human brain
Abstract
Endogenous dopamine (DA) levels at dopamine D2/3 receptors (D2/3R) have been quantified in the living human brain using the agonist radiotracer [11C]‐(+)‐PHNO. As an agonist radiotracer, [11C]‐(+)‐PHNO is more sensitive to endogenous DA levels than antagonist radiotracers. We sought to determine the proportion of the variance in baseline [11C]‐(+)‐PHNO binding to D2/3Rs which can be accounted for by variation in endogenous DA levels. This was done by computing the Pearson's coefficient for the correlation between baseline binding potential (BPND) and the change in BPND after acute DA depletion, using p...
Source: Synapse - July 10, 2016 Category: Neurology Authors: Fernando Caravaggio, Lawrence S. Kegeles, Alan A. Wilson, Gary Remington, Carol Borlido, David C. Mamo, Ariel Graff ‐Guerrero Tags: Research Article Source Type: research
Investigation of the role of alpha ‐2 adrenergic receptors on prepulse inhibition of acoustic startle reflex in rats
Conclusion: Because idazoxan and clonidine also act through imidazoline receptors, our results suggest that alpha‐2 and/or imidazoline receptors are associated with PPI of acoustic startle reflex in rats. Stimulation of these receptors may cause sensorimotor gating disturbances. This article is protected by copyright. All rights reserved.
GRAPHICAL ABSTRACT
Clonidine, an alpha‐2 agonist, produced significant disruptions in PPI of rats. This effect was reversed by specific antagonist idazoxan (figure). Thus, alpha‐2 adrenergic receptor stimulation may cause sensorimotor gating disturbances. (Source: Synapse)
Source: Synapse - July 10, 2016 Category: Neurology Authors: Ayse Ozcetin, Burcu Cevreli, Tayfun Uzbay Tags: Research Article Source Type: research
GSK‐3β inhibitors reverse cocaine‐induced synaptic transmission dysfunction in the Nucleus Accumbens
In conclusion, D1 receptor ‐ GSK3β pathway, which mediates glutamatergic transmission in the NAc core through a presynaptic mechanism, plays an important role in acute cocaine‐ induced hyper‐locomotion. This article is protected by copyright. All rights reserved.
Acute cocaine produces a remarkable inhibition on the AMPA component EPSC via a presynaptic mechanism, we further demonstrated that the effect of cocaine is dependent on D1 dopamine receptor involved in GKS3β pathway. (Source: Synapse)
Source: Synapse - July 5, 2016 Category: Neurology Authors: Rui Zhao, Jiaojiao Chen, Zhaoxiang Ren, Hui Shen, Xuechu Zhen Tags: Research Article Source Type: research
GSK ‐3β inhibitors reverse cocaine‐induced synaptic transmission dysfunction in the Nucleus Accumbens
In conclusion, D1 receptor ‐ GSK3β pathway, which mediates glutamatergic transmission in the NAc core through a presynaptic mechanism, plays an important role in acute cocaine‐ induced hyper‐locomotion. This article is protected by copyright. All rights reserved.
Acute cocaine produces a remarkable inhibition on the AMPA component EPSC via a presynaptic mechanism, we further demonstrated that the effect of cocaine is dependent on D1 dopamine receptor involved in GKS3β pathway. (Source: Synapse)
Source: Synapse - July 4, 2016 Category: Neurology Authors: Rui Zhao, Jiaojiao Chen, Zhaoxiang Ren, Hui Shen, Xuechu Zhen Tags: Research Article Source Type: research
Differential regulation of spontaneous and evoked inhibitory synaptic transmission in somatosensory cortex by retinoic acid
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Graphical Abstract
In addition to its classic roles in brain development, retinoic acid (RA) has recently been shown to regulate excitatory and inhibitory transmission in the adult brain. Here, the authors show that in layer 2/3 (L2/3) of the somatosensory cortex (S1), acute RA induces increases in spontaneous but not action‐potential evoked transmission, and that this requires retinoic acid receptor (RARα) both in presynaptic PV‐positive interneurons and postsynaptic pyramidal (PN) neurons. (Source: Synapse)
Source: Synapse - June 27, 2016 Category: Neurology Authors: Ada Yee, Lu Chen Tags: Research Article Source Type: research
Estimating the effect of endogenous dopamine on baseline [11C]‐(+)‐PHNO binding in the human brain
This article is protected by copyright. All rights reserved.
We estimate the sensitivity of the agonist radioligand [11C]‐(+)‐PHNO for quantifying endogenous dopamine levels at D2/3 receptors in the living human brain. As proof of concept, we use [11C]‐(+)‐PHNO to estimate the in vivo dissociation constant (Kd) for dopamine at D2/3. These results are in accordance with in vitro findings. (Source: Synapse)
Source: Synapse - June 25, 2016 Category: Neurology Authors: Fernando Caravaggio, Lawrence S. Kegeles, Alan A. Wilson, Gary Remington, Carol Borlido, David C. Mamo, Ariel Graff‐Guerrero Tags: Research Article Source Type: research
Post ‐cocaine changes in regulator of G‐protein signaling (RGS) proteins in the dorsal striatum: Relevance for cocaine‐seeking and protein kinase C‐mediated phosphorylation
In conclusion, this study demonstrates persistent dysregulation of RGS proteins in the dSTR of abstinent cocaine animals that may produce an imbalance in local Gαq‐to‐Gαi signaling. This imbalance might be related to augmented PKC‐mediated phosphorylation during relapse to cocaine‐seeking. Future studies will address whether selective targeting of RGS proteins in the dSTR can be utilized to suppress PKC‐mediated phosphorylation and relapse to cocaine‐seeking.
Cocaine self‐administration followed by abstinence alters protein levels of G‐proteins and negative regulators of G‐protein signaling: RGS2/4 and...
Source: Synapse - June 20, 2016 Category: Neurology Authors: Jenna Bilodeau, Marek Schwendt Tags: Research Article Source Type: research
Issue Information
(Source: Synapse)
Source: Synapse - June 14, 2016 Category: Neurology Tags: Issue Information Source Type: research
Post‐cocaine changes in regulator of G‐protein signaling (RGS) proteins in the dorsal striatum: Relevance for cocaine‐seeking and protein kinase C‐mediated phosphorylation
In conclusion, this study demonstrates persistent dysregulation of RGS proteins in the dSTR of abstinent cocaine animals that may produce an imbalance in local Gαq‐to‐Gαi signaling. This imbalance might be related to augmented PKC‐mediated phosphorylation during relapse to cocaine‐seeking. Future studies will address whether selective targeting of RGS proteins in the dSTR can be utilized to suppress PKC‐mediated phosphorylation and relapse to cocaine‐seeking. This article is protected by copyright. All rights reserved.
Cocaine self‐administration followed by abstinence alters protein levels of G‐proteins...
Source: Synapse - June 4, 2016 Category: Neurology Authors: Jenna Bilodeau, Marek Schwendt Tags: Research Article Source Type: research
Differential expression of postsynaptic NMDA and AMPA receptor subunits in the hippocampus and prefrontal cortex of the Flinders Sensitive Line rat model of depression
This article is protected by copyright. All rights reserved. (Source: Synapse)
Source: Synapse - June 3, 2016 Category: Neurology Authors: Giulia Treccani, Kristian Gaarn du Jardin, Gregers Wegener, Heidi Kaastrup Müller Tags: Short Communication Source Type: research
Prediction of striatal D2 receptor binding by DRD2/ANKK1 TaqIA allele status
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We investigated the difference in striatal dopamine D2 receptor binding, as measured by PET with (N‐[11C]methyl)benperidol ([11C]NMB), between A1 allele carriers (A1+) and individuals homozygous for the A2 allele (A1‐) of the DRD2/ANKK1 TaqIA single nucleotide polymorphism. In Study 1, A1+ had 5‐12% less striatal [11C]NMB binding than A1‐. (Source: Synapse)
Source: Synapse - May 31, 2016 Category: Neurology Authors: Sarah A. Eisenstein, Ryan Bogdan, Latisha Love‐Gregory, Nadia S. Corral‐Frías, Jonathan M. Koller, Kevin J. Black, Stephen M. Moerlein, Joel S. Perlmutter, Deanna M. Barch, Tamara Hershey Tags: Research Article Source Type: research
