Issue Information
(Source: Synapse)
Source: Synapse - October 27, 2015 Category: Neurology Tags: Issue Information Source Type: research
Altered NMDA receptor function in primary cultures of hippocampal neurons from mice lacking the Homer2 gene
In conclusion, NMDA receptor function, but not ethanol sensitivity, is reduced in hippocampal neurons lacking the Homer2 gene. This article is protected by copyright. All rights reserved.
Using whole‐cell voltage‐clamp electrophysiology, we demonstrate that constitutive deletion of Homer2 reduces NMDA receptor current density in cultured mature, hippocampal neurons, without influencing the sensitivity of the receptor to alcohol or GluN2b‐selective antagonists. (Source: Synapse)
Source: Synapse - October 2, 2015 Category: Neurology Authors: C. Thetford Smothers, Karen K. Szumlinski, Paul F. Worley, John J. Woodward Tags: Research Article Source Type: research
Positron emission tomography quantification of serotonin transporter binding in medication‐free bipolar disorder
Conclusions: Choice of outcome measure strongly affects comparisons of serotonin transporter binding using PET with [11C]DASB. We do not find evidence of abnormal 5‐HTT binding in bipolar depression using our primary outcome measure, VT/fP. However, we did observe lower 5‐HTT binding in BD with alternative outcome measures that are frequently used with [11C]DASB. Relative merits and assumptions of different outcome measures are discussed. Evaluation in larger samples and during different mood states, including remission, is warranted. This article is protected by copyright. All rights reserved.
Using PET imaging, sero...
Source: Synapse - October 1, 2015 Category: Neurology Authors: Jeffrey M. Miller, Benjamin A. Everett, Maria A. Oquendo, R. Todd Ogden, J. John Mann, Ramin V. Parsey Tags: Research Article Source Type: research
Chronic maternal morphine alters calbindin D‐28k expression pattern in postnatal mouse brain
This article is protected by copyright. All rights reserved.
Daily injection of morphine in adult female mice before mating, during pregnancy and lactation period decreases, in a dose dependent way, the number of Calbindin D‐28k‐immunoreactive neurons in the cingulate and parietal cortical regions (layers II‐IV) and in the hyppocampal granular cells of postnatal mice (P18). (Source: Synapse)
Source: Synapse - September 30, 2015 Category: Neurology Authors: Pratibha Mithbaokar, Filomena Fiorito, Rossella Della Morte, Veeramani Maharajan, Anna Costagliola Tags: Research Article Source Type: research
Dopamine D3 receptor binding of 18F‐Fallypride: Evaluation using in vitro and in vivo PET imaging studies
This article is protected by copyright. All rights reserved.
18F‐Fallypride binds to dopamine D3R as evidenced by its displacement by selective dopamine D3R drugs (R)‐7‐OH‐DPAT, BP 897 and NGB 2904. Up to 20% of 18F‐fallypride may be bound to D3R in vivo in the rat striatum. (Source: Synapse)
Source: Synapse - September 30, 2015 Category: Neurology Authors: Jogeshwar Mukherjee, Cristian C. Constantinescu, Angela T. Hoang, Taleen Jerjian, Divya Majji, Min‐Liang Pan Tags: Research Article Source Type: research
Issue Information
(Source: Synapse)
Source: Synapse - September 17, 2015 Category: Neurology Tags: Issue Information Source Type: research
Stimulation of 5‐HT7 receptor during adolescence determines its persistent upregulation in adult rat forebrain areas
ABSTRACT
Brain serotonin 7 (5‐HT7) receptors play an important functional role in learning and memory, in regulation of mood and motivation, and for circadian rhythms. Recently, we have studied the modulatory effects of a developmental exposure (under subchronic regimen) in rats with LP‐211, a brain‐penetrant and selective 5‐HT7 receptor agonist. We aimed at further deciphering long‐term sequelae into adulthood. LP‐211 (0.250 mg/kg i.p., once/day) was administered for 5 days during the adolescent phase (postnatal days 43–45 to 47–49). When adult (postnatal days >70), forebrain areas were obtained for ...
Source: Synapse - September 14, 2015 Category: Neurology Authors: Paola Nativio, Francesca Zoratto, Emilia Romano, Enza Lacivita, Marcello Leopoldo, Esterina Pascale, Francesca Passarelli, Giovanni Laviola, Walter Adriani Tags: Research Article Source Type: research
[11C]raclopride binding in the striatum of minimally restrained and free‐walking awake mice in a positron emission tomography study
This article is protected by copyright. All rights reserved.
We developed an experimental system enabling PET imaging of free‐walking awake mice. [11C]raclopride‐PET images suggest that our system avoids of the effects of anesthesia and alleviates restraint stress in animal PET studies while measuring the characteristics of neurotransmission components. (Source: Synapse)
Source: Synapse - September 11, 2015 Category: Neurology Authors: Hiroyuki Takuwa, Jun Maeda, Yoko Ikoma, Masaki Tokunaga, Hidekatsu Wakizaka, Shouko Uchida, Iwao Kanno, Junko Taniguchi, Hiroshi Ito, Makoto Higuchi Tags: Research Article Source Type: research
GABA modulates baroreflex in the ventral tegmental area in rat
In conclusion, for the first time, we demonstrated that, GABAA receptors of the VTA strongly attenuate and GABAB receptors of the VTA moderately attenuate baroreflex in rat. This article is protected by copyright. All rights reserved.
The figure shows that the hypertension induced by i.v. injection of phenylephrine before and minutes after GABAA receptor antagonist (BMI) injection into the VTA. BMI strongly augments baroreflex by decreasing the hypertension induced by phenylephrine. Overall, activation of GABAA and GABAB receptors of the VTA attenuate baroreflex. (Source: Synapse)
Source: Synapse - September 11, 2015 Category: Neurology Authors: Masoumeh Hatam, Minoo Rasoulpanah, Ali Nasimi Tags: Research Article Source Type: research
Changes in dendritic spine density in the nucleus accumbens do not underlie ethanol sensitization
This article is protected by copyright. All rights reserved.
Diolistic labelling of accumbens medium spiny neurons after repeated ethanol revealed that saline controls (SAL) low‐sensitized (LS) and high‐sensitized mice (HS) do not differ in overall dendritic spine density, as illustrated. Additional analyses, however, indicated that LS mice have increased density of “stubby”‐type spines. (Source: Synapse)
Source: Synapse - September 5, 2015 Category: Neurology Authors: Christina N. Nona, Marie Kristel Bermejo, Amy J. Ramsey, José N. Nobrega Tags: Short Communication Source Type: research
Issue Information
(Source: Synapse)
Source: Synapse - August 20, 2015 Category: Neurology Tags: Issue Information Source Type: research
Conditional self‐discrimination enhances dendritic spine number and dendritic length at prefrontal cortex and hippocampal neurons of rats
This article is protected by copyright. All rights reserved.
Conditional self‐discrimination in Sprague‐Dawley rats. Golgi‐Cox stain method. Pyramidal neurons of the CA1 dorsal hippocampus and layer 3 of the prefrontal cortex. Changes in dendritic length and dendritic spines. (Source: Synapse)
Source: Synapse - August 14, 2015 Category: Neurology Authors: Julio C. Penagos‐Corzo, Andrea Bonilla, Antonio Rodríguez‐Moreno, Gonzalo Flores, José V. Negrete‐Díaz Tags: Research Article Source Type: research
Computational Modeling of Extracellular Dopamine Kinetics Suggests Low Probability of Neurotransmitter Release
This article is protected by copyright. All rights reserved.
Computational modeling of extracellular dopamine associate with a striatal release site suggests that at baseline conditions vesicular release probability associated with each firing event is low. This suggests that factors capable of increasing release probability could have a powerful effect on sculpting phasic dopamine signals. (Source: Synapse)
Source: Synapse - August 7, 2015 Category: Neurology Authors: Katherine E. Rooney, Lane J. Wallace Tags: Research Article Source Type: research
Brainstem system of hippocampal theta induction: The role of the ventral tegmental area
This article is protected by copyright. All rights reserved.
Graphical abstract text:
Hippocampal theta oscillations are associated with voluntary locomotor activities, spatial navigation or learning and they appear in REM sleep. Under anesthesia, theta is induced by sensory stimulation. The midbrain ventral tegmental area (VTA), apart from well‐studied other brain structures, can also be involved in the regulation of theta rhythm. (Source: Synapse)
Source: Synapse - August 1, 2015 Category: Neurology Authors: Jolanta Orzeł‐Gryglewska, Paweł Matulewicz, Edyta Jurkowlaniec Tags: Review Article Source Type: research
Possible involvement of the sigma‐1 receptor chaperone in chemotherapeutic‐induced neuropathic pain
This article is protected by copyright. All rights reserved.
Graphical Abstract
Chemotherapeutic induced neuropathic pain accompanied by a significant reduction of the Sig‐1R level in Sig‐1R agonist SA4503 reversible manner. (Source: Synapse)
Source: Synapse - August 1, 2015 Category: Neurology Authors: Tomohisa Mori, Junpei Ohya, Aki Masumoto, Masato Harumiya, Mika Fukase, Kazumi Yoshizawa, Teruo Hayashi, Tsutomu Suzuki Tags: Research Article Source Type: research
