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(Source: Synapse)
Source: Synapse - January 23, 2017 Category: Neurology Tags: Issue Information Source Type: research
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(Source: Synapse)
Source: Synapse - January 23, 2017 Category: Neurology Tags: Cover Image Source Type: research
Whole Genome Grey and White matter DNA Methylation Profiles in Dorsolateral Prefrontal cortex
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Using whole genome bisulfite sequencing and highthroughput arrays, the authors characterize the DNA methylation patterns of white and grey matter in the prefrontal cortex. Genes differentially methylated were found to be enriched in molecular pathways highly relevant for neuron/glia function and neurodegenerative diseases. (Source: Synapse)
Source: Synapse - January 20, 2017 Category: Neurology Authors: Jose Vicente Sanchez ‐Mut, Holger Heyn, Enrique Vidal, Raúl Delgado‐Morales, Sebastian Moran, Sergi Sayols, Juan Sandoval, Isidre Ferrer, Manel Esteller, Johannes Gräff Tags: Research Article Source Type: research
Visual ‐tactile processing in primary somatosensory cortex emerges before cross‐modal experience
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Combining extracellular recordings in vivo and anatomical investigations in pre‐juvenile rats, the authors show that the processing of visual‐tactile information and the underlying direct connectivity between the primary sensory cortices emerge before and to a large extent independently of cross‐modal experience. (Source: Synapse)
Source: Synapse - January 19, 2017 Category: Neurology Authors: Malte Bieler, Kay Sieben, Sandra Schildt, Brigitte R öder, Ileana L. Hanganu‐Opatz Tags: Research Article Source Type: research
Smad anchor for receptor activation contributes to seizures in temporal lobe epilepsy
Conclusion: Our results demonstrate that SARA/Smad3 pathway contributes to mechanism of seizure and SARA in TGF‐β signaling may be a potential therapeutic target for epilepsy. This article is protected by copyright. All rights reserved.
SARA and downstream p‐Smad3 signaling is significantly increased in the brain of epileptic rats. Moreover, knockdown SARA leads to the down‐regulation of p‐Smad3 and more importantly postpones seizures. Therefore, TGF‐β signaling via regulation of SARA contributes to mechanism of seizure and SARA is a potential therapeutic target of TLE. (Source: Synapse)
Source: Synapse - December 30, 2016 Category: Neurology Authors: Weihua Yu, Yingshi Du, Yan Zou, Xuefeng Wang, Ulrich Stephani, Yang L ü Tags: Research Article Source Type: research
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(Source: Synapse)
Source: Synapse - December 22, 2016 Category: Neurology Tags: Issue Information Source Type: research
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(Source: Synapse)
Source: Synapse - December 22, 2016 Category: Neurology Tags: Cover Image Source Type: research
VTA DA neuron excitatory synapses in Shank3 Δex4‐9 mouse line
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In the Ventral Tegmental Area, depending on which Shank3 isforms are downregulated or absent, the synaptic phenotype is different (Source: Synapse)
Source: Synapse - December 21, 2016 Category: Neurology Authors: Bariselli Sebastiano, Bellone Camilla Tags: Short Communication Source Type: research
Curcuma treatment prevents cognitive deficit and alteration of neuronal morphology in the limbic system of aging rats
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We examined the effect of curcuma on aging rats. Neural dendritic morphology in the prefrontal cortex, the hippocampus and the basolateral amygdala was measured after 8 weeks of curcuma administration in the aging animals. Curcuma ameliorated the effect of aging on memory process and dendritic morphology in aging rats. (Source: Synapse)
Source: Synapse - December 21, 2016 Category: Neurology Authors: Blanca Vidal, Rub én A Vázquez‐Roque, Dino Gnecco, Raúl G. Enríquez, Benjamin Floran, Alfonso Díaz, Gonzalo Flores Tags: Research Article Source Type: research
Distribution of Type I corticotropin ‐releasing factor (CRF1) receptors on GABAergic neurons within the basolateral amygdala
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CRF1 receptors are differentially distributed on GABAergic interneuron subtypes of the basolateral amygdala (Source: Synapse)
Source: Synapse - December 19, 2016 Category: Neurology Authors: Katina C. Calakos, Dakota Blackman, Alexandra M. Schulz, Elizabeth P. Bauer Tags: Research Article Source Type: research
Inhibitors of oxidative and hydrolytic endocannabinoid degradation do not enhance depolarization ‐induced suppression of excitation on dorsal cochlear nucleus glycinergic neurons
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Effects of JZL184 and sodium salicylate on the DSE in cartwheel neurons from the dorsal cochlear nucleus. (Source: Synapse)
Source: Synapse - December 19, 2016 Category: Neurology Authors: Jo ão Zugaib, Ricardo M Leão Tags: Research Article Source Type: research
Food deprivation facilitates reinstatement of morphine ‐induced conditioned place preference: Role of intra‐accumbal dopamine D2‐like receptors in associating reinstatement of morphine CPP with stress
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Role of intra‐accumbal dopamine D2‐like receptors in the ineffective morphine dose+ FD‐ and morphine priming‐induced reinstatement; the 24‐h FD facilitated morphine reinstatement. D2‐like receptor antagonist attenuated the ineffective morphine dose+ FD‐ and morphine priming‐induced reinstatement dose‐dependently. (Source: Synapse)
Source: Synapse - November 30, 2016 Category: Neurology Authors: Fatemeh Sadeghzadeh, Vahab Babapour, Abbas Haghparast Tags: Research Article Source Type: research
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(Source: Synapse)
Source: Synapse - November 24, 2016 Category: Neurology Tags: Issue Information Source Type: research
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(Source: Synapse)
Source: Synapse - November 24, 2016 Category: Neurology Tags: Cover Image Source Type: research
PET Radiotracer Development for Imaging High ‐Affinity State of Dopamine D2 and D3 Receptors: Binding Studies of Fluorine‐18 Labeled Aminotetralins in Rodents
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“The authors report high‐affinity state binding of dopamine D2/D3 receptor agonists, 18F‐5‐OH‐FPPAT and 18F‐5‐OH‐FHXPAT in in vitro and ex vivo studies and may be reflective of high‐affinity state binding in PET studies. Preferential ventral striatum binding of 18F‐7‐OH‐FHXPAT in PET study is consistent with preferred D3 receptor binding”. (Source: Synapse)
Source: Synapse - November 19, 2016 Category: Neurology Authors: Jogeshwar Mukherjee, Divya Majji, Jasmeet Kaur, Cristian C. Constantinescu, Tanjore K. Narayanan, Bingzhi Shi, Mohamed T. Nour, Min ‐Liang Pan Tags: Research Article Source Type: research
