Issue Information
(Source: Synapse)
Source: Synapse - April 26, 2017 Category: Neurology Tags: Issue Information Source Type: research
Cover image
(Source: Synapse)
Source: Synapse - April 26, 2017 Category: Neurology Tags: Cover Image Source Type: research
NMDAR ‐Independent Hippocampal Long‐Term Depression Impairment after Status Epilepticus in a Lithium‐Pilocarpine Model of Temporal Lobe Epilepsy
This article is protected by copyright. All rights reserved.
Using in vitro electrophysiology, we found that status epilepticus affected the NMDAR‐dependent and NMDAR‐independent forms of long‐term depression in a different manner. The NMDAR‐dependent form of LTD changed its locus of expression, but was almost intact 3 days after SE (A), while the NMDAR‐independent LTD in the rat hippocampal Schaffer collaterals‐CA1 synapses was fully abolished 3 days after SE (B). (Source: Synapse)
Source: Synapse - April 22, 2017 Category: Neurology Authors: Andrey D. Ivanov, Aleksey V. Zaitsev Tags: Research Article Source Type: research
[18F]Nifene test ‐retest reproducibility in first‐in‐human imaging of α4β2* nicotinic acetylcholine receptors
Conclusion: The binding profile and tracer kinetics of [18F]nifene make it a promising α4β2* nAChR radiotracer for scientific research in humans, with reliable DVR test‐retest reproducibility. This article is protected by copyright. All rights reserved.
Graphical Abstract Text
Fluorine‐18 labeled nifene is a novel radiotracer that binds to α4β2* nicotinic acetylcholine receptors rapidly and reliably. First‐in‐human [18F]nifene images demonstrate a pattern consistent with known α4β2* nicotinic acetylcholine receptor sites. It is suitable for in vivo investigation of addiction or neurodegenerative disease, amo...
Source: Synapse - April 18, 2017 Category: Neurology Authors: Patrick J Lao, Tobey J Betthauser, Dana L Tudorascu, Todd E Barnhart, Ansel T Hillmer, Charles K Stone, Jogeshwar Mukherjee, Bradley T Christian Tags: Research Article Source Type: research
The current clinical knowledge on the treatment of gambling disorder: A summary
This article is protected by copyright. All rights reserved.
Graphical Abstract Text
Summary of drugs so far studied for gambling disorder in humans. Green arrow indicates drug with convincing clinical data, orange ones indicate potentially useful drugs, where more data are needed to confirm their efficiency and red arrow represents drugs without superiority over the placebo. (Source: Synapse)
Source: Synapse - April 18, 2017 Category: Neurology Authors: Karel Hloch, P řemysl Mladěnka, Martin Doseděl, Walter Adriani, Francesca Zoratto Tags: Review Article Source Type: research
Role of allopregnanolone biosynthesis in acute stress ‐induced anxiety‐like behaviors in mice
This article is protected by copyright. All rights reserved.
Finasteride, which is a 5α‐reductase inhibitor, pretreated immobilization‐stressed mice decreased the % of time spent in open arms of EPM test. In contrast, alfaxalone, the ALLO mimetic drug, increased the % of time spent in open arms of EPM test in finasteride (10mg/kg)‐pretreated immobilization‐stressed mice. Therefore, ALLO biosynthesis may contribute to stress resistance. (Source: Synapse)
Source: Synapse - April 13, 2017 Category: Neurology Authors: Kazumi Yoshizawa, Ayano Okumura, Kozue Nakashima, Tomoyo Sato, Tatsuya Higashi Tags: Research Article Source Type: research
Adenosine A1 receptors measured with 11C ‐MPDX PET in early Parkinson's disease
This article is protected by copyright. All rights reserved.
11C‐MPDX PET did not reveal significant differences in the striatal density of adenosine A1 receptors between healthy subjects and patients with early Parkinson's disease. Our study suggested that adenosine A1 receptors are unaltered in the putamen in early Parkinson's disease. (Source: Synapse)
Source: Synapse - April 13, 2017 Category: Neurology Authors: Masahiro Mishina, Kenji Ishii, Yuichi Kimura, Masahiko Suzuki, Shin Kitamura, Kenji Ishibashi, Muneyuki Sakata, Keiichi Oda, Shiro Kobayashi, Kazumi Kimura, Kiichi Ishiwata Tags: Research Article Source Type: research
U18666A, an Activator of Sterol Regulatory Element Binding Protein (SREBP) Pathway Modulates Presynaptic Dopaminergic Phenotype of SH ‐SY5Y Neuroblastoma Cells
This article is protected by copyright. All rights reserved.
Using an activator of SREBP (sterol regulatory element‐binding protein), the authors show that the SREBP transcriptional activation reinforces the dopaminergic phenotype of the SH‐SY5Y neuroblastoma cells. This dopaminergic differentiation may lead to the restoration of the presynaptic dopamine markers and may contribute to neuroprotection of dopaminergic neurons afforded by statins. (Source: Synapse)
Source: Synapse - April 13, 2017 Category: Neurology Authors: Mathieu Schmitt, Benjamin Dehay, Erwan Bezard, F. Javier Garcia ‐Ladona Tags: Research Article Source Type: research
Issue Information
(Source: Synapse)
Source: Synapse - March 24, 2017 Category: Neurology Tags: ISSUE INFORMATION Source Type: research
Cover image
(Source: Synapse)
Source: Synapse - March 24, 2017 Category: Neurology Tags: COVER IMAGE Source Type: research
The FENS ‐Kavli Network for Excellence in Neuroscience: Advancing Science through Collaboration and Advocacy
(Source: Synapse)
Source: Synapse - March 21, 2017 Category: Neurology Authors: Panayiota Poirazi, Benjamin Hall Tags: Editorial Source Type: research
GABAA and GABAB receptor dysregulation in superior frontal cortex of subjects with schizophrenia and bipolar disorder
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Graphical Abstract
Using western blotting, the authors show abnormal expression of GABAA and GABAB receptor subunits in superior frontal cortex of subjects with schizophrenia and bipolar disorder. These findings suggest abnormal GABAergic neurotransmission which may help explain behavioral deficits in these disorders. (Source: Synapse)
Source: Synapse - March 18, 2017 Category: Neurology Authors: S. Hossein Fatemi, Timothy D. Folsom, Paul D. Thuras Tags: Research Article Source Type: research
Synergistic Effects of G ‐CSF and Bone Marrow Stromal Cells on Nerve Regeneration with Acellular Nerve Xenografts
In conclusion, G‐CSF administration and BMSCs transplantation synergistically promoted the regeneration of ANX‐bridged nerves, which offers a superior strategy to replace autografts in repairing peripheral nerve injuries. This article is protected by copyright. All rights reserved.
We examined the synergistic effects of G‐CSF and BMSCs on peripheral nerve repairs with acellular nerve xenografts (ANX). The axonal regeneration in the nerve grafts of ANX+BMSCs+G‐CSF group were enhanced significantly. Moreover, the expression of Schwann cell markers, neurotrophic factors and neovessel markers in the nerve grafts was s...
Source: Synapse - March 17, 2017 Category: Neurology Authors: Hua Jia, Ying Wang, Tao Wang, Yi Dong, Wei ‐Li Li, Jun‐Ping Li, Wen‐Zhi Ma, Xiao‐Jie Tong, Zhong‐Yi He Tags: Research Article Source Type: research
Pattern separation in the Hippocampus through the eyes of computational modeling
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Graphical Abstract
The authors review various computational models that study pattern separation, i.e., the ability of the brain to distinguish similar, overlapping memories. (Source: Synapse)
Source: Synapse - March 17, 2017 Category: Neurology Authors: Spyridon Chavlis, Panayiota Poirazi Tags: Review Article Source Type: research
Oral ambroxol increases brain glucocerebrosidase activity in a nonhuman primate
In this study, we analyze the effect of ambroxol treatment on GCase activity in healthy nonhuman primates. We show that daily administration of ambroxol results in increased brain GCase activity. Our work further indicates that ambroxol should be investigated as a novel therapy for both PD and neuronopathic GD in humans.
Treatment with 100 mg of ambroxol leads to approximately a 20% increase in brain glucocerebrosidase activity in a nonhuman primate. (Source: Synapse)
Source: Synapse - March 16, 2017 Category: Neurology Authors: Anna Migdalska ‐Richards, Wai Kin D. Ko, Qin Li, Erwan Bezard, Anthony H. V. Schapira Tags: SHORT COMMUNICATION Source Type: research
