Methamphetamine‐Induced Enhancement of Hippocampal LTP Is Modulated by NMDA and GABA Receptors in the Shell–Accumbens
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Schematic hypothetical model of polysynaptic effects of NAc in modulation of METH‐induced hippocampal plasticity. By blocking dopamine uptake and increasing dopamine efflux, METH increases dopamine concentration in the DAT containing brain regions (striatum and hippocampus). METH modifies hippocampal synaptic plasticity by affecting dopamine neurotransmission in the reward system. According reciprocal connectivity through the hippocampus‐NAc‐VTA‐loop, reducing the inhibitory GABAergic tone of NAc by AP5 or Muscimol reverses the effect of METH on hippocam...
Source: Synapse - March 31, 2016 Category: Neurology Authors: Soomaayeh Heysieattalab, Nasser Naghdi, Narges Hosseinmardi, Mohammad‐Reza Zarrindast, Abbas Haghparast, Habibeh Khoshbouei Tags: Research Article Source Type: research
Knockout of p11 attenuates the acquisition and reinstatement of cocaine conditioned place preference in male but not in female mice
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The lack of protein p11 confers protection from cocaine conditioned place preference on male, but not female mice immediately after cocaine conditioning as well as after prolonged abstinence, but not after short‐term withdrawal. (Source: Synapse)
Source: Synapse - March 17, 2016 Category: Neurology Authors: Panayotis K. Thanos, Lauren Malave, Foteini Delis, Paul Mangine, Katie Kane, Adam Grunseich, Melissa Vitale, Paul Greengard, Nora D. Volkow Tags: Research Article Source Type: research
Changes in the expression of IL‐6‐mediated microRNAs in the dorsal root ganglion under neuropathic pain in mice
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Sciatic nerve ligation induces the increase in the expression of miR‐21 in the DRG and blood exosomes via IL‐6 signaling pathway. Therefore, miR‐21 could be a diagnostic biomarker for the neuropathic pain. (Source: Synapse)
Source: Synapse - March 15, 2016 Category: Neurology Authors: Naosuke Hori, Michiko Narita, Akira Yamashita, Hiroshi Horiuchi, Yusuke Hamada, Takashige Kondo, Moe Watanabe, Katsuhide Igarashi, Miho Kawata, Masahiro Shibasaki, Mitsuaki Yamazaki, Naoko Kuzumaki, Eiichi Inada, Takahiro Ochiya, Masako Iseki, Tomohisa Mo Tags: Research Article Source Type: research
Issue Information
(Source: Synapse)
Source: Synapse - March 15, 2016 Category: Neurology Tags: Issue Information Source Type: research
Permeability of blood–brain barrier in macaque model of 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine‐induced Parkinson disease
ABSTRACT
Brain bioavailability of drugs developed to address central nervous system diseases is classically documented through cerebrospinal fluid collected in normal animals, i.e., through an approximation as there are fundamental differences between cerebrospinal fluid and tissue contents. The fact that disease might affect brain availability of drugs is almost never considered at this stage although several conditions are associated with blood–brain barrier damage. Building upon our expertise in Parkinson's disease translational research, the present study addressed this gap comparing plasma and cerebrospinal fluid bi...
Source: Synapse - March 15, 2016 Category: Neurology Authors: Thibaud Thiollier, Caisheng Wu, Hugues Contamin, Qin Li, Jinlan Zhang, Erwan Bezard Tags: Research Article Source Type: research
Nicotine regulates cocaine‐amphetamine‐regulated transcript (CART) in the mesocorticolimbic system
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Western Blot and qPCR analysis showed that nicotine (0.2, 0.4, 0.6 mg/kg, sc) administration for 6 days regulated CART peptide and mRNA expression in the rat mesocorticolimbic system. (Source: Synapse)
Source: Synapse - March 14, 2016 Category: Neurology Authors: Egemen Kaya, Oguz Gozen, Muzeyyen Ugur, Ersin O. Koylu, Lutfiye Kanit, Burcu Balkan Tags: Research Article Source Type: research
Distinct dendritic morphology across the blades of the rodent dentate gyrus
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Using the Golgi‐Cox technique, the authors show morphological differences between the granule cells of the suprapyramidal blade (DGsp) and infrapyramidal blade (DGip) of the dentate gyrus. In both rats and mice, more dendritic material is observed in the region receiving medial perforant path input. This provides a potential anatomical substrate for the asymmetric activity in the DG in response to spatial input. (Source: Synapse)
Source: Synapse - March 1, 2016 Category: Neurology Authors: Amelia L. Gallitano, Elham Satvat, Mario Gil, Diano F. Marrone Tags: Research Article Source Type: research
Resistance to ethanol sensitization is associated with a loss of synaptic plasticity in the hippocampus
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Only resistant mice to ethanol locomotor sensitization showed an abolition of hippocampus LTD, accompanied with an upregulation of GluN2A subunit of the NMDA receptor. (Source: Synapse)
Source: Synapse - February 22, 2016 Category: Neurology Authors: F. Coune, B. Silvestre de Ferron, M. C. González‐Marín, J. Antol, M. Naassila, O. Pierrefiche Tags: Research Article Source Type: research
Issue Information
(Source: Synapse)
Source: Synapse - February 18, 2016 Category: Neurology Tags: Issue Information Source Type: research
NMDA receptors amplify mossy fiber synaptic inputs at frequencies up to at least 750 Hz in cerebellar granule cells
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Using whole‐cell patch‐clamp recordings from cerebellar granule cells (GC), we show that GCs can process mossy‐fiber (MF) input frequencies of at least 750 Hz. NMDA receptors amplify the integration of these high frequencies, but do not affect single postsynaptic potentials. Thus, NMDA receptors enable signaling at exceptional high frequencies. (Source: Synapse)
Source: Synapse - February 17, 2016 Category: Neurology Authors: Carolin Baade, Niklas Byczkowicz, Stefan Hallermann Tags: Research Article Source Type: research
Brain PET measurement of PDE10A occupancy by TAK‐063, a new PDE10A inhibitor, using [11C]T‐773 in nonhuman primates
In conclusion, this nonhuman primate PET study demonstrated that [11C]T‐773 is useful to estimate the PDE10A occupancy by TAK‐063 in the striatum although there is in vivo interaction of the uptake between [11C]T‐773 and TAK‐063 in the cerebellum. These results warrant further clinical occupancy study for TAK‐063. This article is protected by copyright. All rights reserved.
The target occupancy of a new PDE10A inhibitor, TAK‐063, was evaluated using [11C]T‐773. The authors show that the target occupancy was appropriately estimated even there was interaction between [11C]T‐773 and TAK‐063 in brain regions...
Source: Synapse - February 16, 2016 Category: Neurology Authors: Akihiro Takano, Vladimir Stepanov, Ryuji Nakao, Nahid Amini, Balázs Gulyás, Haruhide Kimura, Christer Halldin Tags: Research Article Source Type: research
Baclofen prevents the elevated plus maze behavior and BDNF expression during naloxone precipitated morphine withdrawal in male and female mice
ABSTRACT
In previous studies we have shown that baclofen, a selective GABAB receptor agonist, prevents the somatic expression and reestablishes the dopamine and μ‐opioid receptors levels, modified during naloxone‐precipitated morphine withdrawal syndrome in male and female mice. There are no previous reports regarding sex differences in the elevated plus maze (EPM) and the expression of BDNF in morphine‐withdrawn mice. The present study analyses the behavioral and biochemical variations during morphine withdrawal in mice of both sexes, and whether these variations are prevented with baclofen. Swiss‐Webster albino ...
Source: Synapse - February 16, 2016 Category: Neurology Authors: Valeria T. Pedrón, André P. Varani, Graciela N. Balerio Tags: Research Article Source Type: research
Evaluation of [11C]TAZA for amyloid β plaque imaging in postmortem human Alzheimer's disease brain region and whole body distribution in rodent PET/CT
Conclusion: [11C]TAZA exhibited high binding to Aβ plaques in human AD hippocampus. Rat brain kinetics was slow and peripheral binding to IBAT needs to be further evaluated. Synapse, 2016. © 2016 Wiley Periodicals, Inc.
[11C]TAZA exhibited high binding to Aβ plaques in human AD hippocampus with grey matter to white matter ratios >20 with little binding in normal controls. Rat brain kinetics was slow but plateaued in 60 min. Peripheral binding in the rats to brown adipose tissue was observed. (Source: Synapse)
Source: Synapse - February 11, 2016 Category: Neurology Authors: Min‐Liang Pan, Meenakshi T. Mukherjee, Himika H. Patel, Bhavin Patel, Cristian C. Constantinescu, M. Reza Mirbolooki, Christopher Liang, Jogeshwar Mukherjee Tags: Research Article Source Type: research
