Characterization of a 3xTg ‐AD mouse model of Alzheimer's disease with the senescence accelerated mouse prone 8 (SAMP8) background
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Heterozygous female 3xTg‐AD mice with senescence‐accelerated prone 8 (SAMP8) background displayed a more severe AD‐like neuropathology compared to senescence‐resistant‐1 (SAMR1) controls. (Source: Synapse)
Source: Synapse - January 18, 2018 Category: Neurology Authors: Jessica Virgili, Meryem Lebbadi, Cyntia Tremblay, Isabelle St ‐Amour, Caroline Pierrisnard, Audrey Faucher‐Genest, Vincent Emond, Carl Julien, Frédéric Calon Tags: Research Article Source Type: research
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Synapse,Volume 72, Issue 4, April 2018. (Source: Synapse)
Source: Synapse - January 17, 2018 Category: Neurology Source Type: research
Juvenile taiep rats have shorter dendritic trees in the dorsal field of the hippocampus without spatial learning disabilities
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Myelin mutant taiep rats had shorter dendrites and fewer dendritic boutons respect to normal Sprague‐Dawley rats in the CA1, but not in CA3 field of the hippocampus. The changes in the dendrites did not affect espacial memory measured through water Morris test in taiep rats. (Source: Synapse)
Source: Synapse - January 12, 2018 Category: Neurology Authors: Adriana B. Silva, Dolores A. Bravo ‐Duran, Jose R. Eguibar, Carmen Cortes Tags: Research Article Source Type: research
Issue Information
(Source: Synapse)
Source: Synapse - December 25, 2017 Category: Neurology Tags: ISSUE INFORMATION Source Type: research
Different effects of chronic THC on the neuroadaptive response of dopamine D2/3 receptor ‐mediated signalling in Roman high‐ and Roman low‐avoidance rats
This article is protected by copyright. All rights reserved.
Using ex vivo measures of [18F]Fallypride and [3H]‐(+)‐PHNO bindings and the psychomotor response to quinpirole, we found that chronic THC induces a neurochemical and functional supersensitivity of striatal dopamine D2/3 receptors in the psychostimulant‐resistant RLA rats. In contrast, the high psychostimulant‐responsive RHA rats appeared resistant to the THC‐induced neuroadaptive changes in D2/3 receptors. (Source: Synapse)
Source: Synapse - December 19, 2017 Category: Neurology Authors: Benjamin B. Tournier, Andrea Dimiziani, Stergios Tsartsalis, Philippe Millet, Nathalie Ginovart Tags: Research Article Source Type: research
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Synapse,Volume 72, Issue 4, April 2018. (Source: Synapse)
Source: Synapse - December 19, 2017 Category: Neurology Source Type: research
An open ‐label positron emission tomography study to evaluate serotonin transporter occupancy following escalating dosing regimens of (R)‐(–)‐O‐desmethylvenlafaxine and racemic O‐desmethylvenlafaxine
This study compared the serotonin transporter (SERT) occupancy achieved by SEP‐227162 and ODV, at daily doses of 25, 50, 100, and 150 mg using [11C]DASB positron emission tomography (PET). Sixteen healthy male subjects participated in one of four dose groups (N = 4 per group) during which they were administered two doses of the study drug (SEP‐227162 or ODV). For each study drug, total daily doses of 25, 50, 100, and150 mg were studied. Subjects underwent three PET scans with [11C]DASB. A baseline, off‐medication, scan was performed prior to dosing and a [11C]DASB PET scan was performed after 72 hr at each dose l...
Source: Synapse - December 13, 2017 Category: Neurology Authors: W. Gordon Frankle, Brigitte Robertson, Gary Maier, Jennifer Paris, Deanna Asmonga, Maureen May, Michael L. Himes, N. Scott Mason, Chester A. Mathis, Rajesh Narendran Tags: RESEARCH ARTICLE Source Type: research
Juvenile social experience and differential age ‐related changes in the dendritic morphologies of subareas of the prefrontal cortex in rats
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The structure of neurons in orbital prefrontal cortex is modified by social housing in an age‐ and housing‐dependent manner. This suggests that the degree of pruning depends on both the age and the specific functional demands of the areas involved. (Source: Synapse)
Source: Synapse - December 12, 2017 Category: Neurology Authors: B. T. Himmler, R. Mychasiuk, A. Nakahashi, S. M. Himmler, S. M. Pellis, B. Kolb Tags: Research Article Source Type: research
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Synapse,Volume 72, Issue 4, April 2018. (Source: Synapse)
Source: Synapse - December 12, 2017 Category: Neurology Source Type: research
An Open ‐Label Positron Emission Tomography (PET) Study to Evaluate Serotonin Transporter Occupancy Following Escalating Dosing Regimens of (R)‐(‐)‐O‐desmethylvenlafaxine and Racemic O‐Desmethylvenlafaxine
Conclusion: In vitro data suggests a ratio of 3.3:1 for binding at human SERT for SEP‐227162 relative to ODV. Our study suggests a ratio of 1.7:1, highlighting the value of in vivo imaging in the drug development process. This article is protected by copyright. All rights reserved.
It has been shown that minimally effective doses of SSRIs (including paroxetine, sertraline, citalopram, fluoxetine, venlafaxine) responsible for antidepressant activity clinically correspond to steady‐state serotonin transporter (SERT) occupancies of ∼80%. This study examined the SERT occupancy of SEP‐227162, an enantiomer of desvenlaf...
Source: Synapse - December 8, 2017 Category: Neurology Authors: W. Gordon Frankle, Brigitte Robertson, Gary Maier, Jennifer Paris, Deanna Asmonga, Maureen May, Michael L Himes, N. Scott Mason, Chester A. Mathis, Rajesh Narendran Tags: Research Article Source Type: research
THC alters alters morphology of neurons in medial prefrontal cortex, orbital prefrontal cortex, and nucleus accumbens and alters the ability of later experience to promote structural plasticity
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Both repeated exposure to Delta 9‐Tetrahydrocannabinol (THC) and housing in complex environments changes the morphology of dendrites in medial prefrontal cortex, orbital frontal cortex and nucleus accumbens. Prior exposure to THC influenced the effect of later experience in complex environments to shape the structure of neurons in these three regions. (Source: Synapse)
Source: Synapse - November 27, 2017 Category: Neurology Authors: Bryan Kolb, Yilin Li, Terry Robinson, Linda A. Parker Tags: Research Article Source Type: research
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(Source: Synapse)
Source: Synapse - November 27, 2017 Category: Neurology Tags: ISSUE INFORMATION Source Type: research
Cover Image
Cover illustration: The cover image, by Krisztian Toth et al., is based on the Research Article Ghrelin receptor antagonism of hyperlocomotion in cocaine‐sensitized mice requires βarrestin‐2, DOI: 10.1002/syn.22012. (Source: Synapse)
Source: Synapse - November 27, 2017 Category: Neurology Tags: ISSUE INFORMATION Source Type: research
Evaluation of ( ‐)‐[18F]Flubatine‐specific binding: Implications for reference region approaches
Abstract
We aimed to characterize changes in binding of (‐)‐[18F]Flubatine to α4β2*‐nicotinic acetylcholine receptors (α4β2*‐nAChRs) during a tobacco cigarette smoking challenge. Displacement of (‐)‐[18F]Flubatine throughout the brain was quantified as change in (‐)‐[18F]Flubatine distribution volume (VT), with particular emphasis on regions with low VT. Three tobacco smokers were imaged with positron emission tomography (PET) during a 210 min bolus‐plus‐constant infusion of (‐)‐[18F]Flubatine. A tobacco cigarette was smoked in the PET scanner ∼125 min after the start of (‐)‐[18F]Flubatin...
Source: Synapse - November 17, 2017 Category: Neurology Authors: Shivani Bhatt, Ansel T. Hillmer, Nabeel Nabulsi, David Matuskey, Keunpoong Lim, Shu ‐Fei Lin, Irina Esterlis, Richard E. Carson, Yiyun Huang, Kelly P. Cosgrove Tags: RESEARCH ARTICLE Source Type: research
[11C]arachidonic acid incorporation measurement in human brain: Optimization for clinical use
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Repeatability of [11C]arachidonic acid brain incorporation coefficient measurements, obtained in humans in a 6‐week interval between PET scans to simulate a treatment study design, is comparable to that of other radiotracers used in neuroimaging. Simplifying data acquisition through eliminating blood sampling and metabolite analysis, while retaining repeatability, may be possible. (Source: Synapse)
Source: Synapse - November 16, 2017 Category: Neurology Authors: Francesca Zanderigo, Yeona Kang, Dileep Kumar, Anastasia Nikolopoulou, P. David Mozley, Paresh J. Kothari, Bin He, David Schlyer, Stanley I. Rapoport, Maria A. Oquendo, Shankar Vallabhajosula, J. John Mann, M. Elizabeth Sublette Tags: Research Article Source Type: research
