The role of Ca2+ ‐dependent K+‐ channels at the rat corticostriatal synapses revealed by paired pulse stimulation
This article is protected by copyright. All rights reserved.
Using whole cell technique and specific KCa channel blockers, we determine that BK‐ but not SK channels decrease paired pulse ratio. These data indicate that KCa channels are located in the presynaptic membrane in proximity to the active zone, and play a role in regulating neurotransmitter release at the corticostriatal synapse. (Source: Synapse)
Source: Synapse - November 14, 2017 Category: Neurology Authors: Angel A. Robles G., Ana V Vega, Carolina Gonzalez ‐Sandoval, Jaime Barral Tags: Research Article Source Type: research
Evaluation of ( ‐)‐[18F]Flubatine Specific Binding: Implications for Reference Region Approaches
This article is protected by copyright. All rights reserved.
We observed displacement of (‐)‐[18F]Flubatine binding to α4β2*‐nicotinic acetylcholine receptors in corpus callosum by a tobacco cigarette challenge. We conclude that reference region approaches utilizing corpus callosum should first perform careful characterization of displaceable (‐)‐[18F]Flubatine binding and non‐displaceable kinetics in this putative reference region. (Source: Synapse)
Source: Synapse - November 3, 2017 Category: Neurology Authors: Shivani Bhatt, Ansel T. Hillmer, Nabeel Nabulsi, David Matuskey, Keunpoong Lim, Shu ‐fei Lin, Irina Esterlis, Richard E. Carson, Yiyun Huang, Kelly P. Cosgrove Tags: Research Article Source Type: research
Issue Information
(Source: Synapse)
Source: Synapse - October 25, 2017 Category: Neurology Tags: ISSUE INFORMATION Source Type: research
Diffusion Entropy: A Potential Neuroimaging Biomarker of Bipolar Disorder in the Temporal Pole
This article is protected by copyright. All rights reserved.
A novel diffusion tensor imaging metric, entropy of diffusion, is significantly lower in individuals with bipolar disorder than healthy controls in the bilateral temporal pole. This metric allows for sensitive and specific prospective classification of bipolar and healthy individuals. (Source: Synapse)
Source: Synapse - September 28, 2017 Category: Neurology Authors: Karl Spuhler, Elizabeth Bartlett, Jie Ding, Christine DeLorenzo, Ramin Parsey, Chuan Huang Tags: Research Article Source Type: research
Proteomic Identification of Synaptic Caspase Substrates
This article is protected by copyright. All rights reserved.
The authors utilized a gel‐based proteomics approach to identify synaptic substrates of caspases, employing both an in vitro system with recombinant activated caspases as well as an in vivo model of ethanol‐induced neuronal apoptosis. Of the >70 putative cleavage substrates that were identified, 22 were previously known caspase substrates. The image depicts western blot validation of in vitro caspase 3 cleavage of N‐ethylmaleimide sensitive fusion protein (NSF), a key mediator of synaptic vesicle membrane fusion. (Source: Synapse)
Source: Synapse - September 28, 2017 Category: Neurology Authors: Ken G. Victor, Daniel S. Heffron, Jennifer D. Sokolowski, Usnish Majumder, Andrea Leblanc, James W. Mandell Tags: Research Article Source Type: research
Issue Information
(Source: Synapse)
Source: Synapse - September 25, 2017 Category: Neurology Tags: ISSUE INFORMATION Source Type: research
Cover Image
Cover illustration: The cover image, by Atsuko Nagano‐Saito et al., is based on the Research Article Posterior dopamine D2/3 receptors and brain network functional connectivity, DOI: 10.1002/syn.21993. (Source: Synapse)
Source: Synapse - September 25, 2017 Category: Neurology Authors: Atsuko Nagano ‐Saito, Jennifer I. Lissemore, Paul Gravel, Marco Leyton, Felix Carbonell, Chawki Benkelfat Tags: ISSUE INFORMATION Source Type: research
Ghrelin receptor antagonism of hyperlocomotion in cocaine ‐sensitized mice requires βarrestin‐2
This article is protected by copyright. All rights reserved.
Dopamine neuron‐specific βarrestin‐2 KO mice and WT littermates can be sensitized to cocaine to the same extent. In KO mice, however, the ghrelin receptor antagonist YIL781 cannot block cocaine‐induced hyperlocomotion. This demonstrates a selective requirement of βarrestin‐2 activity in the distinct stages of addictive behavior. (Source: Synapse)
Source: Synapse - September 24, 2017 Category: Neurology Authors: Krisztian Toth, Lauren M. Slosky, Thomas F. Pack, Nikhil M. Urs, Peter Boone, Lan Mao, Dennis Abraham, Marc G. Caron, Lawrence S. Barak Tags: Research Article Source Type: research
Maternal Immune Activation Leads to Increased nNOS Immunoreactivity in the Brain of Postnatal Day 2 Rat Offspring
This article is protected by copyright. All rights reserved.
Representative images showing the distribution and morphology of nNOS‐immunoreactive cells in the striatum of male control (A, C) and maternal immune activation (MIA; B, D) offspring. There were significantly increased nNOS‐immunoreactive cells in the striatum in the male and female MIA offspring relative to their sex‐matched controls, and in the male controls when compared to the female controls (E). (Source: Synapse)
Source: Synapse - September 16, 2017 Category: Neurology Authors: Jiaxian Zhang, Yu Jing, Hu Zhang, David K. Bilkey, Ping Liu Tags: Research Article Source Type: research
Neuroprotective Effect of Amantadine on Corticosterone ‐induced Abnormal Glutamatergic Synaptic Transmission of CA3‐CA1 pathway in rat's hippocampal slices
This article is protected by copyright. All rights reserved.
In the present study, the authors found that amantadine significantly alleviated corticosterone‐induced alterations in the glutamatergic synaptic transmission of CA3‐CA1 synapses presynaptically and the activities of antioxidant enzymes via possibly regulating the calcium influx. (Source: Synapse)
Source: Synapse - September 13, 2017 Category: Neurology Authors: Xi Xiao, Hui Zhang, Hui Wang, Qun Li, Tao Zhang Tags: Research Article Source Type: research
Carbonic anhydrase inhibitor acetazolamide shifts synaptic vesicle recycling to a fast mode at the mouse neuromuscular junction
This article is protected by copyright. All rights reserved.
Acetazolamide (AZ) an inhibitor of an enzyme that regulates pH inside and outside the cells is used to treat ataxia and epilepsy. Combined experiments using fluorescence dyes and electrophysiological techniques at the mice neuromuscular junction suggests that AZ shift synaptic vesicle recycling to a fast mode which may contribute to the therapeutic action reported. (Source: Synapse)
Source: Synapse - September 5, 2017 Category: Neurology Authors: Nicolas Ivan Bertone, Ayel én Ivana Groisman, Graciela Lujan Mazzone, Raquel Cano, Lucia Tabares, Osvaldo Daniel Uchitel Tags: Research Article Source Type: research
Sr2+ has low efficiency in regulating spontaneous release at the Calyx of Held synapses
This study employed cell‐attached and pre/post‐synaptic whole‐cell recording at the Calyx of Held synapse in synaptotagmin‐2 knock‐out mice and revealed that Sr2+ has higher permeability through voltage gated calcium channels and lower efficiency in regulating spontaneous neurotransmitter release than Ca2+. (Source: Synapse)
Source: Synapse - August 31, 2017 Category: Neurology Authors: Shuli Zhang, Xuefeng Wang, Xiaohui Wang, Xuefeng Shen, Jianyuan Sun, Xintian Hu, Peihua Chen Tags: Research Article Source Type: research
Issue Information
(Source: Synapse)
Source: Synapse - August 26, 2017 Category: Neurology Tags: ISSUE INFORMATION Source Type: research
LP ‐211, a selective 5‐HT7 receptor agonist, increases novelty‐preference and promotes risk‐prone behavior in rats
This article is protected by copyright. All rights reserved. (Source: Synapse)
Source: Synapse - July 28, 2017 Category: Neurology Authors: G. Beaudet, E. Paizanis, F. Zoratto, E. Lacivita, M. Leopoldo, T. Freret, G. Laviola, M. Boulouard, W. Adriani Tags: Research Article Source Type: research
Issue Information
(Source: Synapse)
Source: Synapse - July 26, 2017 Category: Neurology Tags: ISSUE INFORMATION Source Type: research
