Cover Image
Cover illustration: The cover image, by Fading Chen and Benjamin J. Hall, is based on the Research Article Synaptic activity suppresses expression of neurogenic differentiation factor 2 in an NMDA receptor‐dependent manner, DOI: 10.1002/syn.21986. (Source: Synapse)
Source: Synapse - July 26, 2017 Category: Neurology Authors: Fading Chen, Benjamin J. Hall Tags: ISSUE INFORMATION Source Type: research
Posterior Dopamine D2/3 Receptors and Brain Network Functional Connectivity
This article is protected by copyright. All rights reserved.
The posterior distribution of D2/3 receptors binding (hot colour spectrum) coincides with the functional connectivity of the posterior portion of the default mode network (green colour spectrum). The mean BPND in a posteromedial cortex and the mean ICA‐Z score in the precuneus showed significant positive correlation. (Source: Synapse)
Source: Synapse - July 12, 2017 Category: Neurology Authors: Atsuko Nagano ‐Saito, Jennifer I. Lissemore, Paul Gravel, Marco Leyton, Felix Carbonell, Chawki Benkelfat Tags: Research Article Source Type: research
Learning and memory effects of neonatal methamphetamine exposure in rats: Role of reactive oxygen species and age at assessment
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From P6‐15 rat littermates were administered saline or PBN (antioxidant) before methamphetamine (MA, 10 mg/kg x 4) or saline. MA impaired Cincinnati, Morris, and Radial water maze learning and contextual fear but not in cued fear or passive avoidance. PBN did not ameliorate MA's effects. (Source: Synapse)
Source: Synapse - July 8, 2017 Category: Neurology Authors: Sarah A. Jablonski, Michael T. Williams, Charles V. Vorhees Tags: Research Article Source Type: research
Pregnancy improves cognitive deficit and neuronal morphology atrophy in the prefrontal cortex and hippocampus of aging Spontaneously Hypertensive rats
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We analyzed the pregnancy effect on aged rats with chronic hypertension. Learning and memory process and neural dendritic morphology in the prefrontal cortex and the hippocampus after pregnancy was discussed in the animal hypertensive model. Pregnancy reduced the chronic hypertension effect on memory process and dendritic atrophy in aged rats. (Source: Synapse)
Source: Synapse - July 6, 2017 Category: Neurology Authors: Ver ónica R. Cabrera‐Pedraza, María de Jesús Gómez‐Villalobos, Fidel de la Cruz, Patricia Aguilar‐Alonso, Sergio Zamudio, Gonzalo Flores Tags: Research Article Source Type: research
Alzheimer's disease and metabolic syndrome: A link from oxidative stress and inflammation to neurodegeneration
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Metabolic syndrome promotes signaling pathways at a peripheral and cerebral level, which accelerates the onset of neurodegenerative diseases, such as Alzheimer's disease. (Source: Synapse)
Source: Synapse - June 26, 2017 Category: Neurology Authors: Eduardo Rojas ‐Gutierrez, Guadalupe Muñoz‐Arenas, Samuel Treviño, Blanca Espinosa, Raúl Chavez, Karla Rojas, Gonzalo Flores, Alfonso Díaz, Jorge Guevara Tags: Review Article Source Type: research
Issue Information
(Source: Synapse)
Source: Synapse - June 21, 2017 Category: Neurology Tags: ISSUE INFORMATION Source Type: research
Cover Image
Cover illustration: The cover image, by Patrick J. Lao et al., is based on the Research Article [18F]Nifene test‐retest reproducibility in first‐in‐human imaging of α4β2* nicotinic acetylcholine receptors, DOI: 10.1002/syn.21981 (Source: Synapse)
Source: Synapse - June 21, 2017 Category: Neurology Authors: Patrick J. Lao, Tobey J. Betthauser, Dana L. Tudorascu, Todd E. Barnhart, Ansel T. Hillmer, Charles K. Stone, Jogeshwar Mukherjee, Bradley T. Christian Tags: ISSUE INFORMATION Source Type: research
U18666A, an activator of sterol regulatory element binding protein pathway, modulates presynaptic dopaminergic phenotype of SH ‐SY5Y neuroblastoma cells
In this study, we aimed to determine the direct role of SREBP pathway in the modulation of dopaminergic phenotype. We demonstrate that treatment of SH‐SY5Y cells with U18666A, an SREBP activator, increases the translocation of SREBPs into the nucleus, increases the expression of SREBP‐1, SREBP‐2, and of the presynaptic dopaminergic markers such as vesicular monoamine transporter 2, synaptic vesicle glycoprotein 2 A and 2 C, synaptogyrin‐3, and tyrosine hydroxylase. The addition of SREBP inhibitor, PF‐429242, blocks the increase of U18666A‐induced expression of SREBPs and presynaptic markers. Our results, in lin...
Source: Synapse - June 20, 2017 Category: Neurology Authors: Mathieu Schmitt, Benjamin Dehay, Erwan Bezard, F. Javier Garcia ‐Ladona Tags: RESEARCH ARTICLE Source Type: research
Developmental effects of antipsychotic drugs on serotonin receptor subtypes
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Using receptor autoradiography, the authors found that forebrain 5‐HT receptor subtypes in juvenile animals are more sensitive than adults to the long‐term effects of dissimilar antipsychotic drugs, which may account for differences in clinical effects of antipsychotic drugs between young vs. adult psychiatric patients. (Source: Synapse)
Source: Synapse - June 9, 2017 Category: Neurology Authors: Yong Kee Choi, Matthew P. Gardner, Frank I. Tarazi Tags: Research Article Source Type: research
The aminoestrogen prolame increases recognition memory and hippocampal neuronal spine density in aged mice
In conclusion, prolame administration promotes hippocampal plasticity processes but not in the NAcc neurons of aged mice, thus improving long‐term recognition memory. Prolame could become a pharmacological alternative to prevent or delay the brain aging process, and thus the emergence of neurodegenerative diseases that affect memory. This article is protected by copyright. All rights reserved.
The treatment with prolame improves the recognition memory and dendritic morphology of the hippocampus and NAcc in aging mice, providing more evidence to be considered as a tool to delay the aging of the brain. (Source: Synapse)
Source: Synapse - May 26, 2017 Category: Neurology Authors: Alfonso Diaz, Samuel Trevi ño, Rubén Vázquez‐Roque, Berenice Venegas, Blanca Espinosa, Gonzalo Flores, Juan Manuel Fernández‐G, Luis F. Montaño, Jorge Guevara Tags: Research Article Source Type: research
Issue Information
(Source: Synapse)
Source: Synapse - May 24, 2017 Category: Neurology Tags: ISSUE INFORMATION Source Type: research
Synaptic Activity Suppresses Expression of Neurogenic Differentiation Factor 2 in an NMDA Receptor ‐Dependent Manner
This article is protected by copyright. All rights reserved. (Source: Synapse)
Source: Synapse - May 19, 2017 Category: Neurology Authors: Fading Chen, Benjamin J. Hall Tags: Research Article Source Type: research
Chronic nicotine ‐induced changes in gene expression of delta and kappa‐opioid receptors and their endogenous ligands in the mesocorticolimbic system of the rat
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Chronic subcutaneous nicotine administration regulated prodynorphin (PDYN), kappa (KOR) and delta (DOR) opioid receptor mRNA expression in the rat mesocorticolimbic system. Proenkephalin (PENK) mRNA was not altered in any of the brain regions studied: ventral tegmental area (VTA), lateral hypothalamus (LHA), amygdala (AMG), nucleus accumbens (NAc), dorsal striatum (DST), medial prefrontal cortex (mPFC). (Source: Synapse)
Source: Synapse - May 16, 2017 Category: Neurology Authors: Muzeyyen Ugur, Egemen Kaya, Oguz Gozen, Ersin O. Koylu, Lutfiye Kanit, Aysegul Keser, Burcu Balkan Tags: Research Article Source Type: research
Interleukin 6 trans ‐signaling regulates basal synaptic transmission and sensitivity to pentylenetetrazole‐induced seizures in mice
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Inflammation does not only affect immune processes but also brain function, in an unknown manner. The proinflammatory cytokine interleukin‐6 acts in the brain mainly through a mechanism denominated trans‐signaling. Synaptic and behavioral excitability were increased in a transgenic model lacking interleukin 6 trans‐signaling specifically in the brain. (Source: Synapse)
Source: Synapse - May 9, 2017 Category: Neurology Authors: Roberto Cuevas ‐Olguin, Eric Esquivel‐Rendon, Jorge Vargas‐Mireles, Francisco Garcias‐Oscos, Marcela Miranda‐Morales, Humberto Salgado, Stefan Rose‐John, Marco Atzori Tags: Research Article Source Type: research
[18F]Nifene test –retest reproducibility in first‐in‐human imaging of α4β2* nicotinic acetylcholine receptors
Conclusion: The binding profile and tracer kinetics of [18F]nifene make it a promising α4β2* nAChR radiotracer for scientific research in humans, with reliable DVR test–retest reproducibility.
Fluorine‐18 labeled nifene is a novel radiotracer that binds to α4β2* nicotinic acetylcholine receptors rapidly and reliably. First‐in‐human [18F]nifene images demonstrate a pattern consistent with known α4β2* nicotinic acetylcholine receptor sites. It is suitable for in vivo investigation of addiction or neurodegenerative disease, among other things. (Source: Synapse)
Source: Synapse - April 26, 2017 Category: Neurology Authors: Patrick J. Lao, Tobey J. Betthauser, Dana L. Tudorascu, Todd E. Barnhart, Ansel T. Hillmer, Charles K. Stone, Jogeshwar Mukherjee, Bradley T. Christian Tags: RESEARCH ARTICLE Source Type: research
