Interleukin 6 trans ‐signaling regulates basal synaptic transmission and sensitivity to pentylenetetrazole‐induced seizures in mice

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Inflammation does not only affect immune processes but also brain function, in an unknown manner. The proinflammatory cytokine interleukin‐6 acts in the brain mainly through a mechanism denominated trans‐signaling. Synaptic and behavioral excitability were increased in a transgenic model lacking interleukin 6 trans‐signaling specifically in the brain.

Source: Synapse - May 9, 2017 Category: Neurology Authors: Roberto Cuevas ‐Olguin, Eric Esquivel‐Rendon, Jorge Vargas‐Mireles, Francisco Garcias‐Oscos, Marcela Miranda‐Morales, Humberto Salgado, Stefan Rose‐John, Marco Atzori Tags: Research Article Source Type: research