[18F]Nifene test –retest reproducibility in first‐in‐human imaging of α4β2* nicotinic acetylcholine receptors
Conclusion: The binding profile and tracer kinetics of [18F]nifene make it a promising α4β2* nAChR radiotracer for scientific research in humans, with reliable DVR test–retest reproducibility.
Fluorine‐18 labeled nifene is a novel radiotracer that binds to α4β2* nicotinic acetylcholine receptors rapidly and reliably. First‐in‐human [18F]nifene images demonstrate a pattern consistent with known α4β2* nicotinic acetylcholine receptor sites. It is suitable for in vivo investigation of addiction or neurodegenerative disease, among other things.
Source: Synapse - Category: Neurology Authors: Patrick J. Lao, Tobey J. Betthauser, Dana L. Tudorascu, Todd E. Barnhart, Ansel T. Hillmer, Charles K. Stone, Jogeshwar Mukherjee, Bradley T. Christian Tags: RESEARCH ARTICLE Source Type: research