Calcium channel blockade attenuates abnormal synaptic transmission in the dentate gyrus elicited by entorhinal amyloidopathy
In conclusion, our results suggest that Aβ in the EC triggers decreased excitatory transmission in the DG with substantial decrement in AMPA currents, leading to a prominent activity of inhibitory circuits and increased inhibition of granule cells which may contribute to the development of AD‐related neurological deficits in AD and treatment by CCBs could preserve normal synaptic transmission against Aβ toxicity. This article is protected by copyright. All rights reserved.
Using whole cell patch clamp, the authors show that entorhinal amyloidopathy triggers a decreased excitatory transmission and paired pulse facilit...
Source: Synapse - May 31, 2016 Category: Neurology Authors: Hamid Gholami Pourbadie, Nima Naderi, Mahyar Janahmadi, Nasrin Mehranfard, Fereshteh Motamedi Tags: Research Article Source Type: research
DAT versus D2 receptor binding in the rat striatum: l ‐DOPA‐induced motor activity is better predicted by reuptake than release of dopamine
ABSTRACT
The reuptake and release of dopamine (DA) can be estimated using in vivo imaging methods by assessing the competition between endogenous DA and an administered exogenous DA transporter (DAT) and D2 receptor (D2R) radioligand, respectively. The aim of this study was to investigate the comparative roles of DA release vs DA reuptake in the rat striatum with small animal SPECT in relation to l‐DOPA‐induced behaviors. DAT and D2R binding, together with behavioral measures, were obtained in 99 rats in response to treatment with either 5 or 10 mg/kg l‐DOPA or vehicle. The behavioral parameters included the distance...
Source: Synapse - May 29, 2016 Category: Neurology Authors: Susanne Nikolaus, Markus Beu, Maria Angelica De Souza Silva, Joseph P. Huston, Hubertus Hautzel, Christina Antke, Hans ‐Wilhelm Müller Tags: Research Article Source Type: research
DAT versus D2 receptor binding in the rat striatum: l‐DOPA‐induced motor activity is better predicted by reuptake than release of dopamine
ABSTRACT
The reuptake and release of dopamine (DA) can be estimated using in vivo imaging methods by assessing the competition between endogenous DA and an administered exogenous DA transporter (DAT) and D2 receptor (D2R) radioligand, respectively. The aim of this study was to investigate the comparative roles of DA release vs DA reuptake in the rat striatum with small animal SPECT in relation to l‐DOPA‐induced behaviors. DAT and D2R binding, together with behavioral measures, were obtained in 99 rats in response to treatment with either 5 or 10 mg/kg l‐DOPA or vehicle. The behavioral parameters included the distance...
Source: Synapse - May 29, 2016 Category: Neurology Authors: Susanne Nikolaus, Markus Beu, Maria Angelica De Souza Silva, Joseph P. Huston, Hubertus Hautzel, Christina Antke, Hans‐Wilhelm Müller Tags: Research Article Source Type: research
Mediation of buprenorphine analgesia by a combination of traditional and truncated mu opioid receptor splice variants
This article is protected by copyright. All rights reserved.
The mu opioid receptor gene Oprm1 undergoes alternatively splicing to generate several sets of splice variants. Traditional 7TM MOR‐1 variants mediate morphine actions. The current study shows that buprenorphine produces analgesia through a combination of 7TM and 6TM splice variants. (Source: Synapse)
Source: Synapse - May 26, 2016 Category: Neurology Authors: Steven G. Grinnell, Michael Ansonoff, Gina F. Marrone, Zhigang Lu, Ankita Narayan, Jin Xu, Grace Rossi, Susruta Majumdar, Ying‐Xian Pan, Daniel L. Bassoni, John Pintar, Gavril Pasternak Tags: Research Article Source Type: research
Issue Information
(Source: Synapse)
Source: Synapse - May 23, 2016 Category: Neurology Tags: Issue Information Source Type: research
DAT vs D2 receptor binding in the rat striatum: L‐DOPA‐induced motor activity is better predicted by reuptake than release of dopamine
This article is protected by copyright. All rights reserved.
DAT and D2 receptor binding were assessed in the rat striatum in relation to L‐DOPA‐induced behaviors. Changes in DA reuptake in response to fluctuating DA levels better predict motor activity than the release of DA into the synaptic cleft. (Source: Synapse)
Source: Synapse - May 11, 2016 Category: Neurology Authors: Susanne Nikolaus, Markus Beu, Maria Angelica De Souza Silva, Joseph P. Huston, Hubertus Hautzel, Christina Antke, Hans‐Wilhelm Müller Tags: Research Article Source Type: research
Cerebrolysin improves memory and ameliorates neuronal atrophy in spontaneously hypertensive, aged rats
This study aimed to determine whether Cbl was capable of reducing behavioral and neuronal alterations, in old female SH rats. The level of diastolic and systolic pressure was measured every month for the 6 first months and only animals with more than 160 mm Hg of systolic pressure were used. Female SH rats (6 months old) received 6 months of Cbl treatment. Immediately after the Cbl treatment, two behavioral tests were applied, the Morris water maze test for memory and learning and locomotor activity in novel environments. Immediately after the last behavioral test, dendritic morphology was studied with the Golgi‐Cox stai...
Source: Synapse - May 9, 2016 Category: Neurology Authors: Carlos Solis‐Gaspar, Ruben A Vazquez‐Roque, Ma. de Jesús Gómez‐Villalobos, Gonzalo Flores Tags: Research Article Source Type: research
Electrophysiology of cerebral ischemia and reperfusion: First evidence for the role of synapse in ischemic tolerance
Conclusions: Our data indicated that a mild reduction in brain perfusion without permanent lesion can dramatically increase the basal synaptic transmission. This effect may be associated with an increase in the neurotransmitter content of the pre‐synaptic neurons. This hypothesis could provide a new insight into the relationship between ischemic tolerance and synaptic efficacy. This article is protected by copyright. All rights reserved.
An interesting consequence of our experiment is that excitability and basal synaptic transmission robustly increased seven days after mild ischemia. If we consider mild ischemia as a st...
Source: Synapse - April 29, 2016 Category: Neurology Authors: Masoud Haghani, Somaye Keshavarz, Maryam Nazari, Ali Rafati Tags: Research Article Source Type: research
Synaptic number changes in the medial prefrontal cortex across adolescence in male and female rats: A role for pubertal onset
This article is protected by copyright. All rights reserved.
Stereological assessment of immunoreactive synaptophysin boutons in the mPFC between early adolescence and adulthood revealed significant pruning that was larger in females than males. Additionally, pubertal onset in both males and females was associated with decreases in synapse number, suggesting a role for pubertal hormones in regulating synaptic pruning. (Source: Synapse)
Source: Synapse - April 22, 2016 Category: Neurology Authors: Carly M. Drzewiecki, Jari Willing, Janice M. Juraska Tags: Research Article Source Type: research
Issue Information
(Source: Synapse)
Source: Synapse - April 18, 2016 Category: Neurology Tags: Issue Information Source Type: research
Activation of β‐adrenergic receptors in rat visual cortex expands astrocytic processes and reduces extracellular space volume
This study implies that βAR‐induced shrinkage of ECS increases the concentration of neuroactive substances, thereby impacting neuronal communication, neuron‐glia interactions, and processing of sensory information in the visual cortex during global release of norepinephrine. (Source: Synapse)
Source: Synapse - April 17, 2016 Category: Neurology Authors: Ang Doma Sherpa, Fanrong Xiao, Neethu Joseph, Chiye Aoki, Sabina Hrabetova Tags: Research Article Source Type: research
Methamphetamine‐induced enhancement of hippocampal long‐term potentiation is modulated by NMDA and GABA receptors in the shell–accumbens
In this study, we tested the hypothesis that manipulation of glutamatergic and GABA‐ergic systems in the shell‐NAc modulates METH‐induced enhancement of long term potentiation (LTP) in the hippocampus. Rats treated with METH (four injections of 5 mg/kg) exhibited enhanced LTP as compared to saline‐treated animals. Intra‐NAc infusion of muscimol (GABA receptor agonist) decreased METH‐induced enhancement of dentate gyrus (DG)‐LTP, while infusion of AP5 (NMDA receptor antagonist) prevented METH‐induced enhancement of LTP. These data support the interpretation that reducing NAc activity can ameliorate METH‐in...
Source: Synapse - April 14, 2016 Category: Neurology Authors: Soomaayeh Heysieattalab, Nasser Naghdi, Narges Hosseinmardi, Mohammad‐Reza Zarrindast, Abbas Haghparast, Habibeh Khoshbouei Tags: Research Article Source Type: research
Sex differences in neurotensin and substance P following nicotine self‐administration in rats
This article is protected by copyright. All rights reserved.
Graphic Abstract Description: In Sprague‐Dawley rats, nicotine self‐administration alters neurotensin‐like immunoreactivity and substance P‐like immunoreactivity differentially in male and female rats. The regulation of neuropeptides following nicotine SA may play a role in the susceptibility to nicotine dependence in females and males. (Source: Synapse)
Source: Synapse - April 13, 2016 Category: Neurology Authors: Steven T. Pittenger, Natashia Swalve, Shinnyi Chou, Misty D. Smith, Amanda J. Hoonakker, Cindy M. Pudiak, Annette E. Fleckenstein, Glen R. Hanson, Rick A. Bevins Tags: Research Article Source Type: research
