Synaptic number changes in the medial prefrontal cortex across adolescence in male and female rats: A role for pubertal onset

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Stereological assessment of immunoreactive synaptophysin boutons in the mPFC between early adolescence and adulthood revealed significant pruning that was larger in females than males. Additionally, pubertal onset in both males and females was associated with decreases in synapse number, suggesting a role for pubertal hormones in regulating synaptic pruning.

Source: Synapse - April 22, 2016 Category: Neurology Authors: Carly M. Drzewiecki, Jari Willing, Janice M. Juraska Tags: Research Article Source Type: research