EPO induces changes in synaptic transmission and plasticity in the dentate gyrus of rats
This article is protected by copyright. All rights reserved.
(A) EPO enhances LTP when administered 15 min before LTP induction. (B) In basal conditions EPO administration induces a slowly developing PSA potentiation. Furthermore, EPO also facilitates LTD induction (C); and prevents depotentiation (D). (Source: Synapse)
Source: Synapse - February 10, 2016 Category: Neurology Authors: William Almaguer‐Melian, Daymara Mercerón‐Martínez, Susana Delgado‐Ocaña, Nancy Pavón‐Fuentes, Nuris Ledón, Jorge A. Bergado Tags: Research Article Source Type: research
Kinetic modeling and long‐term test‐retest reproducibility of the mGluR5 PET tracer 18F‐FPEB in human brain
ABSTRACT
18F‐FPEB is a promising PET tracer for studying the metabotropic glutamate subtype 5 receptor (mGluR5) expression in neuropsychiatric disorders. To assess the potential of 18F‐FPEB for longitudinal mGluR5 evaluation in patient studies, we evaluated the long‐term test‐retest reproducibility using various kinetic models in the human brain. Nine healthy volunteers underwent consecutive scans separated by a 6‐month period. Dynamic PET was combined with arterial sampling and radiometabolite analysis. Total distribution volume (VT) and nondisplaceable binding potential (BPND) were derived from a two‐tissue c...
Source: Synapse - February 8, 2016 Category: Neurology Authors: Gil Leurquin‐Sterk, Andrey Postnov, Bart de Laat, Cindy Casteels, Sofie Celen, Cleo L. Crunelle, Guy Bormans, Michel Koole, Koen Van Laere Tags: Research Article Source Type: research
Subtle alterations of excitatory transmission are linked to presynaptic changes in the hippocampus of PINK1‐deficient mice
This study provides a novel role for PINK1 beyond the physiology of nigrostriatal dopaminergic circuit. Specifically, PINK1 might contribute to preserve synaptic function and glutamatergic homeostasis in the hippocampus, a brain region underlying cognition. The subtle changes in excitatory transmission here observed might be a pathogenic precursor to excitotoxic neurodegeneration and cognitive decline often observed in PD. This article is protected by copyright. All rights reserved.
Using electrophysiological and fluorescence techniques, we demonstrate that lack of PINK1 causes increased excitatory transmission and neurot...
Source: Synapse - February 7, 2016 Category: Neurology Authors: Marco Feligioni, Dalila Mango, Sonia Piccinin, Paola Imbriani, Filomena Iannuzzi, Alessandra Caruso, Francesca De Angelis, Fabio Blandini, Nicola B. Mercuri, Antonio Pisani, Robert Nisticò Tags: Research Article Source Type: research
Evaluation of [11C]TAZA for amyloid β plaque imaging in post‐mortem human alzheimer's disease brain region and whole body distribution in Rodent PET/CT
Conclusion: [11C]TAZA exhibited high binding to Aβ plaques in human AD hippocampus. Rat brain kinetics were slow and peripheral binding to IBAT needs to be further evaluated. This article is protected by copyright. All rights reserved.
[11C]TAZA exhibited high binding to Aβ plaques in human AD hippocampus with grey matter to white matter ratios >20 with little binding in normal controls. Rat brain kinetics was slow but plateaued in 60 minutes. Peripheral binding in the rats to brown adipose tissue was observed. (Source: Synapse)
Source: Synapse - January 27, 2016 Category: Neurology Authors: Min‐Liang Pan, Meenakshi T. Mukherjee, Himika H. Patel, Bhavin Patel, Cristian C. Constantinescu, M. Reza Mirbolooki, Christopher Liang, Jogeshwar Mukherjee Tags: Research Article Source Type: research
Melatonin receptor activation increases glutamatergic synaptic transmission in the rat medial lateral habenula
This article is protected by copyright. All rights reserved.
Using whole cell recordings from rat brain slices, the authors show that melatonin increases the amplitude of excitatory post synaptic currents in the medial lateral habenula via a presynaptic, receptor‐mediated mechanism. (Source: Synapse)
Source: Synapse - January 22, 2016 Category: Neurology Authors: Katherine M Evely, Randall L Hudson, Margarita L Dubocovich, Samir Haj‐Dahmane Tags: Research Article Source Type: research
Chronic administration of resveratrol prevents morphological changes in prefrontal cortex and hippocampus of aged rats
This article is protected by copyright. All rights reserved.
We examined the effect of chronic resveratrol administration in aged rats. Locomotor activity induced by a novel environment was measured. Dendritic morphology was assessed in pyramidal neurons of prefrontal cortex and hippocampus. Resveratrol enhanced the dendritic length and number of spines in aged rats. (Source: Synapse)
Source: Synapse - January 21, 2016 Category: Neurology Authors: Elizabeth Monserrat Hernández‐Hernández, Carolina Serrano‐García, Rubén Antonio Vázquez‐Roque, Alfonso Díaz, Elibeth Monroy, Antonio Rodríguez‐Moreno, Benjamin Florán, Gonzalo Flores Tags: Research Article Source Type: research
Issue Information
(Source: Synapse)
Source: Synapse - January 21, 2016 Category: Neurology Tags: Issue Information Source Type: research
Permeability of blood‐brain barrier in macaque model of 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP)‐induced Parkinson disease
This article is protected by copyright. All rights reserved.
As a pathological state may compromise drug brain bioavailability, we measured the plasma and cerebro‐spinal fluid levels of L‐DOPA, carbamazepine, quinidine, lovastatin and simvastatin in normal and parkinsonian (MPTP) macaque monkeys. Since no major bioavailability differences were observed, we conclude that brain bioavailability can be studied in normal monkeys. (Source: Synapse)
Source: Synapse - January 21, 2016 Category: Neurology Authors: Thibaud Thiollier, Caisheng Wu, Hugues Contamin, Qin Li, Jinlan Zhang, Erwan Bezard Tags: Research Article Source Type: research
Kinetic modelling and long‐term test‐retest reproducibility of the mGluR5 PET tracer 18F‐FPEB in human brain
This article is protected by copyright. All rights reserved.
Using proper kinetic modelling, the authors demonstrate that 18F‐FPEB, a promising PET radioligand for mGluR5, has high long‐term test‐retest reproducibility in healthy subjects. This finding validate the use of 18F‐FPEB as a biomarker for longitudinal monitoring of mGluR5 in various neuropsychiatric disorders. (Source: Synapse)
Source: Synapse - January 21, 2016 Category: Neurology Authors: Gil Leurquin‐Sterk, Andrey Postnov, Bart de Laat, Cindy Casteels, Sofie Celen, Cleo L. Crunelle, Guy Bormans, Michel Koole, Koen Van Laere Tags: Research Article Source Type: research
An acute, epitope‐specific modification in the dopamine transporter associated with methamphetamine‐induced neurotoxicity
This article is protected by copyright. All rights reserved.
Using antibodies directed against its N‐terminus, the authors identified a heretofore unreported, epitope‐specific modification in the dopamine transporter caused by methamphetamine that correlates temporally with a decrease in its function, and may be predictive of the persistent dopaminergic deficits that can be caused by the stimulant. (Source: Synapse)
Source: Synapse - January 21, 2016 Category: Neurology Authors: Ashley N. Fricks‐Gleason, Christopher L. German, Amanda J. Hoonakker, Danielle M. Friend, Kamala K. Ganesh, Aaron S. Carver, Glen R. Hanson, Annette E. Fleckenstein, Kristen A. Keefe Tags: Research Article Source Type: research
Baclofen prevents the elevated plus maze behaviour and bdnf expression during naloxone precipitated morphine withdrawal in male and female mice
This article is protected by copyright. All rights reserved.
Baclofen pretreatment was able to prevent the EPM behaviour in both withdrawn male and female mice and the changes in BDNF expression observed in withdrawn male mice.
Baclofen prevention of the EPM behaviour associated to morphine withdrawal could be partially related to changes in BDNF expression (Source: Synapse)
Source: Synapse - January 20, 2016 Category: Neurology Authors: Valeria T. Pedrón, Andrés P. Varani, Graciela N. Balerio Tags: Research Article Source Type: research
Neuronal changes after chronic high blood pressure in animal models and its implication for vascular dementia
This article is protected by copyright. All rights reserved.
We examined the effect of chronic arterial hypertension and aged in vascular dementia. Neural dendritic morphology in the prefrontal cortex and the dorsal hippocampus and nucleus accumbens after chronic hypertension was discussed in the animal models of hypertension. Chronic hypertension reduced the dendritic length and spine density in aged rats. (Source: Synapse)
Source: Synapse - January 20, 2016 Category: Neurology Authors: Gonzalo Flores, Gabriel D Flores‐Gómez, Ma. de Jesús Gomez‐Villalobos Tags: Review Article Source Type: research
Interpreting DTBZ Binding Data in Rodent: Inherent Variability and Compensation
This article is protected by copyright. All rights reserved.
The striatal binding of DTBZ at baseline between two groups of rats of same age, sex and strain but from different suppliers shows significant differences (**). Following unilateral lesion, the binding in the unlesioned striatum is significantly increased compared to baseline (*). Both observations affect accurate data interpretation. (Source: Synapse)
Source: Synapse - January 12, 2016 Category: Neurology Authors: Miguel Mejias, Jing Yu, Scott Mackey, Katie Dinelle, Vesna Sossi, Doris J. Doudet Tags: Research Article Source Type: research
Neonatal prebiotic (BGOS) supplementation increases the levels of synaptophysin, GluN2A‐subunits and BDNF proteins in the adult rat hippocampus
ABSTRACT
Compelling data suggest that perturbations in microbial colonization of the gut in early‐life, influences neurodevelopment and adult brain function. If this is the case, then ensuring the growth of beneficial bacteria at an early age will lead to optimal brain development and maturation. We have tested whether feeding neonatal rats daily (from post‐natal days 3‐21) with a galacto‐oligosaccharide prebiotic (Bimuno®, BGOS) or a control solution, alters the levels of hippocampal N‐Methyl‐D‐Aspartate receptor (NMDAR) subunits (GluN1, GluN2A, GluN2B), synaptic proteins (synaptophysin, MAP2, and GAP43) an...
Source: Synapse - January 9, 2016 Category: Neurology Authors: Sarah Williams, Li Chen, Helene M. Savignac, George Tzortzis, Daniel C. Anthony, Philip WJ Burnet Tags: Short Communication Source Type: research
