Permeability of blood‐brain barrier in macaque model of 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP)‐induced Parkinson disease
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As a pathological state may compromise drug brain bioavailability, we measured the plasma and cerebro‐spinal fluid levels of L‐DOPA, carbamazepine, quinidine, lovastatin and simvastatin in normal and parkinsonian (MPTP) macaque monkeys. Since no major bioavailability differences were observed, we conclude that brain bioavailability can be studied in normal monkeys.
Source: Synapse - Category: Neurology Authors: Thibaud Thiollier, Caisheng Wu, Hugues Contamin, Qin Li, Jinlan Zhang, Erwan Bezard Tags: Research Article Source Type: research
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