Electrophysiology of cerebral ischemia and reperfusion: First evidence for the role of synapse in ischemic tolerance

Conclusions: Our data indicated that a mild reduction in brain perfusion without permanent lesion can dramatically increase the basal synaptic transmission. This effect may be associated with an increase in the neurotransmitter content of the pre‐synaptic neurons. This hypothesis could provide a new insight into the relationship between ischemic tolerance and synaptic efficacy. This article is protected by copyright. All rights reserved. An interesting consequence of our experiment is that excitability and basal synaptic transmission robustly increased seven days after mild ischemia. If we consider mild ischemia as a stress to trigger ischemic tolerance responses, therefore, basal synaptic transmission could be a major factor causing protection of brain tissue following insult. Our data suggest that mild ischemia directly may play a major role in basal synaptic transmission.
Source: Synapse - Category: Neurology Authors: Tags: Research Article Source Type: research