Different effects of chronic THC on the neuroadaptive response of dopamine D2/3 receptor ‐mediated signalling in Roman high‐ and Roman low‐avoidance rats

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Using ex vivo measures of [18F]Fallypride and [3H]‐(+)‐PHNO bindings and the psychomotor response to quinpirole, we found that chronic THC induces a neurochemical and functional supersensitivity of striatal dopamine D2/3 receptors in the psychostimulant‐resistant RLA rats. In contrast, the high psychostimulant‐responsive RHA rats appeared resistant to the THC‐induced neuroadaptive changes in D2/3 receptors.

Source: Synapse - December 19, 2017 Category: Neurology Authors: Benjamin B. Tournier, Andrea Dimiziani, Stergios Tsartsalis, Philippe Millet, Nathalie Ginovart Tags: Research Article Source Type: research