Evaluation of [11C]TAZA for amyloid β plaque imaging in postmortem human Alzheimer's disease brain region and whole body distribution in rodent PET/CT

Conclusion: [11C]TAZA exhibited high binding to Aβ plaques in human AD hippocampus. Rat brain kinetics was slow and peripheral binding to IBAT needs to be further evaluated. Synapse, 2016. © 2016 Wiley Periodicals, Inc.

[11C]TAZA exhibited high binding to Aβ plaques in human AD hippocampus with grey matter to white matter ratios >20 with little binding in normal controls. Rat brain kinetics was slow but plateaued in 60 min. Peripheral binding in the rats to brown adipose tissue was observed.

Source: Synapse - February 11, 2016 Category: Neurology Authors: Min‐Liang Pan, Meenakshi T. Mukherjee, Himika H. Patel, Bhavin Patel, Cristian C. Constantinescu, M. Reza Mirbolooki, Christopher Liang, Jogeshwar Mukherjee Tags: Research Article Source Type: research