Smad anchor for receptor activation contributes to seizures in temporal lobe epilepsy

Conclusion: Our results demonstrate that SARA/Smad3 pathway contributes to mechanism of seizure and SARA in TGF‐β signaling may be a potential therapeutic target for epilepsy. This article is protected by copyright. All rights reserved.

SARA and downstream p‐Smad3 signaling is significantly increased in the brain of epileptic rats. Moreover, knockdown SARA leads to the down‐regulation of p‐Smad3 and more importantly postpones seizures. Therefore, TGF‐β signaling via regulation of SARA contributes to mechanism of seizure and SARA is a potential therapeutic target of TLE.

Source: Synapse - December 30, 2016 Category: Neurology Authors: Weihua Yu, Yingshi Du, Yan Zou, Xuefeng Wang, Ulrich Stephani, Yang L ü Tags: Research Article Source Type: research