PET Radiotracer Development for Imaging High ‐Affinity State of Dopamine D2 and D3 Receptors: Binding Studies of Fluorine‐18 Labeled Aminotetralins in Rodents

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“The authors report high‐affinity state binding of dopamine D2/D3 receptor agonists, 18F‐5‐OH‐FPPAT and 18F‐5‐OH‐FHXPAT in in vitro and ex vivo studies and may be reflective of high‐affinity state binding in PET studies. Preferential ventral striatum binding of 18F‐7‐OH‐FHXPAT in PET study is consistent with preferred D3 receptor binding”.

Source: Synapse - November 19, 2016 Category: Neurology Authors: Jogeshwar Mukherjee, Divya Majji, Jasmeet Kaur, Cristian C. Constantinescu, Tanjore K. Narayanan, Bingzhi Shi, Mohamed T. Nour, Min ‐Liang Pan Tags: Research Article Source Type: research