Positron emission tomography quantification of serotonin transporter binding in medication‐free bipolar disorder

Conclusions: Choice of outcome measure strongly affects comparisons of serotonin transporter binding using PET with [11C]DASB. We do not find evidence of abnormal 5‐HTT binding in bipolar depression using our primary outcome measure, VT/fP. However, we did observe lower 5‐HTT binding in BD with alternative outcome measures that are frequently used with [11C]DASB. Relative merits and assumptions of different outcome measures are discussed. Evaluation in larger samples and during different mood states, including remission, is warranted. This article is protected by copyright. All rights reserved.

Using PET imaging, serotonin transporter (5‐HTT) binding was quantified in depressed patients with bipolar disorder and in healthy volunteers. Using the primary measure of 5‐HTT binding, no group differences were observed (figure). Secondary binding outcome measures indicated a 5‐HTT binding deficiency in bipolar depression, but replication is required.

Source: Synapse - October 1, 2015 Category: Neurology Authors: Jeffrey M. Miller, Benjamin A. Everett, Maria A. Oquendo, R. Todd Ogden, J. John Mann, Ramin V. Parsey Tags: Research Article Source Type: research