Differential regulation of spontaneous and evoked inhibitory synaptic transmission in somatosensory cortex by retinoic acid

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Graphical Abstract
In addition to its classic roles in brain development, retinoic acid (RA) has recently been shown to regulate excitatory and inhibitory transmission in the adult brain. Here, the authors show that in layer 2/3 (L2/3) of the somatosensory cortex (S1), acute RA induces increases in spontaneous but not action‐potential evoked transmission, and that this requires retinoic acid receptor (RARα) both in presynaptic PV‐positive interneurons and postsynaptic pyramidal (PN) neurons.

Source: Synapse - June 27, 2016 Category: Neurology Authors: Ada Yee, Lu Chen Tags: Research Article Source Type: research